RPN9_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPN9_YEAST
• UniProt AC: Q04062
• Protein Name: 26S proteasome regulatory subunit RPN9
• Gene Name: RPN9
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 393
• Protein Description: Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins..
• Protein Sequence: MFNNHEIDTILSTLRMEADPSLHPLFEQFEKFYEEKLWFQLSESLTKFFDDAKSTPLRLRLYDNFVSKFYDKINQLSVVKYLLASLKDSKDFDESLKYLDDLKAQFQELDSKKQRNNGSKDHGDGILLIDSEIARTYLLKNDLVKARDLLDDLEKTLDKKDSIPLRITNSFYSTNSQYFKFKNDFNSFYYTSLLYLSTLEPSTSITLAERQQLAYDLSISALLGDKIYNFGELLHHPIMETIVNDSNYDWLFQLLNALTVGDFDKFDSLIKVQISKIPILAQHESFLRQKICLMTLIETVFVKNIRMLSFEDISKATHLPKDNVEHLVMRAISLGLLKGSIDQVNELVTISWVQPRIISGDQITKMKDRLVEWNDQVEKLGKKMEARGQSIWV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	FNNHEIDTILSTLRM CCHHHHHHHHHHHHC	29.49	28889911
12	Phosphorylation	HEIDTILSTLRMEAD HHHHHHHHHHHCCCC	22.88	28889911
13	Phosphorylation	EIDTILSTLRMEADP HHHHHHHHHHCCCCC	18.22	28889911
53	Succinylation	TKFFDDAKSTPLRLR HHHHHCCCCCCCCHH	62.95	23954790
53	Acetylation	TKFFDDAKSTPLRLR HHHHHCCCCCCCCHH	62.95	24489116
53	Ubiquitination	TKFFDDAKSTPLRLR HHHHHCCCCCCCCHH	62.95	23749301
68	Acetylation	LYDNFVSKFYDKINQ HHHHHHHHHHHHHHH	42.51	24489116
72	Acetylation	FVSKFYDKINQLSVV HHHHHHHHHHHHHHH	31.98	24489116
77	Phosphorylation	YDKINQLSVVKYLLA HHHHHHHHHHHHHHH	18.33	19795423
87	Succinylation	KYLLASLKDSKDFDE HHHHHHHCCCCCHHH	58.42	23954790
103	Acetylation	LKYLDDLKAQFQELD HHHHHHHHHHHHHHH	47.32	24489116
111	Phosphorylation	AQFQELDSKKQRNNG HHHHHHHHHHHHCCC	55.14	21126336
120	Acetylation	KQRNNGSKDHGDGIL HHHCCCCCCCCCCEE	55.96	24489116
140	Acetylation	IARTYLLKNDLVKAR HHHHHHHHCCHHHHH	45.91	24489116
155	Acetylation	DLLDDLEKTLDKKDS HHHHHHHHHCCCCCC	62.78	24489116
156	Phosphorylation	LLDDLEKTLDKKDSI HHHHHHHHCCCCCCC	30.71	27017623
180	Acetylation	STNSQYFKFKNDFNS CCCCCEEEEECCCHH	50.96	24489116
276	Acetylation	LIKVQISKIPILAQH HHHHHHCCCCCHHCC	54.88	24489116
309	Phosphorylation	VKNIRMLSFEDISKA HCCCCCCCHHHHHHC	19.76	27017623
315	Acetylation	LSFEDISKATHLPKD CCHHHHHHCCCCCCC	58.60	24489116
379	Ubiquitination	EWNDQVEKLGKKMEA HHHHHHHHHHHHHHH	64.78	23749301
379	Acetylation	EWNDQVEKLGKKMEA HHHHHHHHHHHHHHH	64.78	24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPN9_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPN9_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPN9_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RPN11_YEAST	RPN11	physical	11742986
PRS6B_YEAST	RPT3	physical	11595789
SUI1_YEAST	SUI1	physical	11595789
YG2A_YEAST	YGR067C	physical	11595789
VAC14_YEAST	VAC14	physical	11595789
RPN11_YEAST	RPN11	physical	15102831
TAT1_YEAST	TAT1	physical	16554755
SEC18_YEAST	SEC18	physical	16554755
PRS4_YEAST	RPT2	physical	16554755
SAC3_YEAST	SAC3	physical	16554755
PRS6B_YEAST	RPT3	physical	16554755
RPN3_YEAST	RPN3	physical	16554755
RPN11_YEAST	RPN11	physical	16554755
UBP6_YEAST	UBP6	physical	16554755
RPN12_YEAST	RPN12	physical	16554755
PRS8_YEAST	RPT6	physical	16554755
PSD10_YEAST	NAS6	physical	16554755
RPN1_YEAST	RPN1	physical	16554755
RPN10_YEAST	RPN10	physical	16554755
RPN2_YEAST	RPN2	physical	16554755
PRS7_YEAST	RPT1	physical	16554755
RPN13_YEAST	RPN13	physical	16554755
SPG5_YEAST	SPG5	physical	16554755
PRS6A_YEAST	RPT5	physical	16554755
PRS10_YEAST	RPT4	physical	16554755
RPN8_YEAST	RPN8	physical	16554755
RRS1_YEAST	RRS1	physical	16554755
RPN7_YEAST	RPN7	physical	16554755
ECM29_YEAST	ECM29	physical	16429126
RPN10_YEAST	RPN10	physical	16429126
RPN2_YEAST	RPN2	physical	16429126
PRS10_YEAST	RPT4	physical	16429126
PSA6_YEAST	PRE5	physical	16429126
RPN1_YEAST	RPN1	physical	16429126
RPN11_YEAST	RPN11	physical	16429126
RPN12_YEAST	RPN12	physical	16429126
RPN13_YEAST	RPN13	physical	16429126
RPN3_YEAST	RPN3	physical	16429126
RPN5_YEAST	RPN5	physical	16429126
RPN6_YEAST	RPN6	physical	16429126
RPN7_YEAST	RPN7	physical	16429126
RPN8_YEAST	RPN8	physical	16429126
PRS7_YEAST	RPT1	physical	16429126
PRS4_YEAST	RPT2	physical	16429126
PRS6B_YEAST	RPT3	physical	16429126
PRS6A_YEAST	RPT5	physical	16429126
PRS8_YEAST	RPT6	physical	16429126
RPN8_YEAST	RPN8	physical	18467557
PRS6A_YEAST	RPT5	physical	19217412
RPN10_YEAST	RPN10	physical	19217412
SEM1_YEAST	SEM1	physical	19217412
RPN12_YEAST	RPN12	physical	19217412
PSD10_YEAST	NAS6	genetic	19446323
PRS6A_YEAST	RPT5	physical	22460800
HSM3_YEAST	HSM3	physical	22460800
PRS6A_YEAST	RPT5	physical	22307589
RPN10_YEAST	RPN10	physical	10490597
RPN10_YEAST	RPN10	physical	25631053
RPN5_YEAST	RPN5	physical	25631053
RPN10_YEAST	RPN10	physical	27698474

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.