PSA6_YEAST - dbPTM
PSA6_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PSA6_YEAST
UniProt AC P40302
Protein Name Proteasome subunit alpha type-6
Gene Name PRE5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 234
Subcellular Localization Cytoplasm. Nucleus.
Protein Description The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity..
Protein Sequence MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHAVLVALKRNADELSSYQKKIIKCDEHMGLSLAGLAPDARVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNTQSYGGRPYGVGLLIIGYDKSGAHLLEFQPSGNVTELYGTAIGARSQGAKTYLERTLDTFIKIDGNPDELIKAGVEAISQSLRDESLTVDNLSIAIVGKDTPFTIYDGEAVAKYI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationRNNYDGDTVTFSPTG
CCCCCCCEEEECCCC		18.0021126336
14PhosphorylationDGDTVTFSPTGRLFQ
CCCEEEECCCCCEEE		18.0217330950
16PhosphorylationDTVTFSPTGRLFQVE
CEEEECCCCCEEEHH		3.0928889911
94PhosphorylationYLRQQCNYSSLVFNR
HHHHHCCCHHHHHCH		10.9222369663
95PhosphorylationLRQQCNYSSLVFNRK
HHHHCCCHHHHHCHH		5.2022369663
96PhosphorylationRQQCNYSSLVFNRKL
HHHCCCHHHHHCHHH		29.3422369663
115AcetylationAGHLLCDKAQKNTQS
HHHHHCHHHHHCCCC		32.3725381059
118UbiquitinationLLCDKAQKNTQSYGG
HHCHHHHHCCCCCCC		9.3917644757
139UbiquitinationLLIIGYDKSGAHLLE
EEEEEECCCCCEEEE		4.2217644757
169UbiquitinationGARSQGAKTYLERTL
HHCCCCHHHHHHHHH		22.1723749301
181UbiquitinationRTLDTFIKIDGNPDE
HHHHEEEEECCCHHH		36.3923749301
181AcetylationRTLDTFIKIDGNPDE
HHHHEEEEECCCHHH		36.3924489116
191UbiquitinationGNPDELIKAGVEAIS
CCHHHHHHHHHHHHH		6.3422106047
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PSA6_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PSA6_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PSA6_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SHE2_YEASTSHE2physical
10688190
SUB2_YEASTSUB2physical
11595789
GCR2_YEASTGCR2physical
18719252
MCM2_YEASTMCM2physical
18719252
CTF4_YEASTCTF4physical
18719252
MOG1_YEASTMOG1physical
18719252
ADA2_YEASTADA2physical
18719252
URE2_YEASTURE2physical
18719252
RDR1_YEASTRDR1physical
18719252
YAP3_YEASTYAP3physical
18719252
RPN8_YEASTRPN8physical
19412159
PSA7_YEASTPRE10physical
19412159
RPN10_YEASTRPN10genetic
18622397
RPN6_YEASTRPN6genetic
18622397
RPN8_YEASTRPN8genetic
18622397
RPN11_YEASTRPN11genetic
18622397
RPN5_YEASTRPN5genetic
18622397
PSA3_YEASTPRE9genetic
18622397
RPN12_YEASTRPN12genetic
18622397
RPN3_YEASTRPN3genetic
18622397
RPN7_YEASTRPN7genetic
18622397
RPN2_YEASTRPN2genetic
18622397
PRS4_YEASTRPT2genetic
18622397
PSA7_YEASTPRE10genetic
18622397
PRS6B_YEASTRPT3genetic
18622397
PRS8_YEASTRPT6genetic
18622397
PRS6A_YEASTRPT5genetic
18622397
PRS7_YEASTRPT1genetic
18622397
PSB2_YEASTPUP1genetic
18622397
PSA1_YEASTSCL1genetic
18622397
PSB1_YEASTPRE3genetic
18622397
PSA5_YEASTPUP2genetic
18622397
PSA2_YEASTPRE8genetic
18622397
PSB5_YEASTPRE2genetic
18622397
PSB6_YEASTPRE7genetic
18622397
PSB7_YEASTPRE4genetic
18622397
PSA4_YEASTPRE6genetic
18622397
PSA7_YEASTPRE10physical
15253422
PSB7_YEASTPRE4physical
15253422
PSA4_YEASTPRE6physical
22940862
PSB6_YEASTPRE7physical
22940862
PSA7_YEASTPRE10physical
22940862
PSB5_YEASTPRE2physical
22940862
PSA2_YEASTPRE8physical
22940862
PSA6_YEASTPRE5physical
22940862
NAM7_YEASTNAM7genetic
27811238
HOME3_HUMANHOMER3physical
27107014
TRI27_HUMANTRIM27physical
27107014
MCM6_HUMANMCM6physical
27107014
CEP76_HUMANCEP76physical
27107014
NECA2_HUMANNECAB2physical
27107014
FSBP_HUMANRAD54Bphysical
27107014
RA54B_HUMANRAD54Bphysical
27107014
MI4GD_HUMANMIF4GDphysical
27107014
DCTP1_HUMANDCTPP1physical
27107014
MTUS2_HUMANMTUS2physical
27107014
CACO2_HUMANCALCOCO2physical
27107014
BODG_HUMANBBOX1physical
27107014
CARD9_HUMANCARD9physical
27107014
OPTN_HUMANOPTNphysical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PSA6_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237, AND MASSSPECTROMETRY.

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