FSBP_HUMAN - dbPTM
FSBP_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FSBP_HUMAN
UniProt AC O95073
Protein Name Fibrinogen silencer-binding protein
Gene Name FSBP
Organism Homo sapiens (Human).
Sequence Length 299
Subcellular Localization Nucleus .
Protein Description Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1..
Protein Sequence MVGKARSSNFTLSEKLDLLKLVKPYVKILEEHTNKHSVIVEKNRCWDIIAVNYNAIGVDRPPRTAQGLRTLYKRLKEYAKQELLQQKETQSDFKSNISEPTKKVMEMIPQISSFCLVRDRNHIQSANLDEEAQAGTSSLQVMLDHHPVAITVEVKQEEDIKPPPPLVLNSQQSDTLEQREEHELVHVMERSLSPSLSSVDMRMTSSPSSIPRRDDFFRHESGEHFRSLLGYDPQILQMLKEEHQIILENQKNFGLYVQEKRDGLKRRQQLEEELLRAKIEVEKLKAIRLRHDLPEYNSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15 (in isoform 1)Ubiquitination-43.8821890473
15UbiquitinationSNFTLSEKLDLLKLV
CCCCHHHHHHHHHHH		43.8822817900
20UbiquitinationSEKLDLLKLVKPYVK
HHHHHHHHHHHHHHH		59.5422817900
36UbiquitinationLEEHTNKHSVIVEKN
HHHHCCCCEEEEECC		29.3929967540
68UbiquitinationPPRTAQGLRTLYKRL
CCCHHHHHHHHHHHH		2.2229967540
73UbiquitinationQGLRTLYKRLKEYAK
HHHHHHHHHHHHHHH		55.13-
76UbiquitinationRTLYKRLKEYAKQEL
HHHHHHHHHHHHHHH		53.35-
86UbiquitinationAKQELLQQKETQSDF
HHHHHHHHHHHHHHH		45.5929967540
94SumoylationKETQSDFKSNISEPT
HHHHHHHHHCCCHHH		47.8128112733
95PhosphorylationETQSDFKSNISEPTK
HHHHHHHHCCCHHHH		39.1126270265
98PhosphorylationSDFKSNISEPTKKVM
HHHHHCCCHHHHHHH		41.6026270265
101PhosphorylationKSNISEPTKKVMEMI
HHCCCHHHHHHHHHH		39.1726270265
157UbiquitinationITVEVKQEEDIKPPP
EEEEECCCCCCCCCC		52.5029967540
162UbiquitinationKQEEDIKPPPPLVLN
CCCCCCCCCCCEEEC		47.1429967540
187UbiquitinationEEHELVHVMERSLSP
HHHHHHHHHHHHCCC		3.1229967540
191PhosphorylationLVHVMERSLSPSLSS
HHHHHHHHCCCCCCC		21.6423186163
192UbiquitinationVHVMERSLSPSLSSV
HHHHHHHCCCCCCCC		12.5129967540
193PhosphorylationHVMERSLSPSLSSVD
HHHHHHCCCCCCCCC		17.4330108239
195PhosphorylationMERSLSPSLSSVDMR
HHHHCCCCCCCCCEE		37.1923186163
200UbiquitinationSPSLSSVDMRMTSSP
CCCCCCCCEECCCCC		22.4029967540
204PhosphorylationSSVDMRMTSSPSSIP
CCCCEECCCCCCCCC		18.7130108239
205PhosphorylationSVDMRMTSSPSSIPR
CCCEECCCCCCCCCC		30.7927732954
206PhosphorylationVDMRMTSSPSSIPRR
CCEECCCCCCCCCCC		21.4530108239
208PhosphorylationMRMTSSPSSIPRRDD
EECCCCCCCCCCCCC		42.7330108239
209PhosphorylationRMTSSPSSIPRRDDF
ECCCCCCCCCCCCCC		39.7430108239
252UbiquitinationIILENQKNFGLYVQE
HHHHCCCCCCEEHHH		26.8429967540
270UbiquitinationGLKRRQQLEEELLRA
HHHHHHHHHHHHHHH		7.2829967540
298PhosphorylationHDLPEYNSL------
CCCCCCCCC------		34.2630108239
306UbiquitinationL--------------
C--------------		22817900
371Ubiquitination-------------------------------------------------------------------------------
-------------------------------------------------------------------------------		29967540
376Ubiquitination------------------------------------------------------------------------------------
------------------------------------------------------------------------------------		29967540
384Ubiquitination--------------------------------------------------------------------------------------------
--------------------------------------------------------------------------------------------		29967540
406Ubiquitination------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------		29967540
455Ubiquitination-------------------------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------------------------		22817900
459Ubiquitination-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------		22817900
490Ubiquitination------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		22817900
590Ubiquitination----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		29967540
601Ubiquitination---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		29967540
639Ubiquitination-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		22817900
643Ubiquitination---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		22817900
688Ubiquitination------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		29967540
785Ubiquitination-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		29967540
872Ubiquitination----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------		29967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FSBP_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FSBP_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FSBP_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CCD33_HUMANCCDC33physical
16189514
ZN580_HUMANZNF580physical
16189514
GORS2_HUMANGORASP2physical
16189514
TEANC_HUMANTCEANCphysical
16189514
RIBC2_HUMANRIBC2physical
16189514
TPC6A_HUMANTRAPPC6Aphysical
16189514
FSBP_HUMANRAD54Bphysical
16189514
RA54B_HUMANRAD54Bphysical
16189514
LNX1_HUMANLNX1physical
16189514
RAD51_HUMANRAD51physical
10851248
WRN_HUMANWRNphysical
17118963
FSBP_HUMANRAD54Bphysical
19060904
RA54B_HUMANRAD54Bphysical
19060904
FSBP_HUMANRAD54Bphysical
25416956
RA54B_HUMANRAD54Bphysical
25416956
GMCL1_HUMANGMCL1physical
25416956
ENKD1_HUMANENKD1physical
25416956
ATPF2_HUMANATPAF2physical
25416956
TEANC_HUMANTCEANCphysical
25416956
MDM2_HUMANMDM2physical
25384516
PLCG2_HUMANPLCG2physical
25814554
SH22A_HUMANSH2D2Aphysical
25814554
SUMO1_HUMANSUMO1physical
21516116
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FSBP_HUMAN

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Related Literatures of Post-Translational Modification

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