dbPTM

WRN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WRN_HUMAN
UniProt AC	Q14191
Protein Name	Werner syndrome ATP-dependent helicase
Gene Name	WRN
Organism	Homo sapiens (Human).
Sequence Length	1432
Subcellular Localization	Nucleus, nucleolus . Nucleus . Nucleus, nucleoplasm . Gamma-irradiation leads to its translocation from nucleoli to nucleoplasm and PML regulates the irradiation-induced WRN relocation.
Protein Description	Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. May play an important role in the dissociation of joint DNA molecules that can arise as products of homologous recombination, at stalled replication forks or during DNA repair. Alleviates stalling of DNA polymerases at the site of DNA lesions. Important for genomic integrity. Plays a role in the formation of DNA replication focal centers; stably associates with foci elements generating binding sites for RP-A (By similarity). Plays a role in double-strand break repair after gamma-irradiation..
Protein Sequence	MSEKKLETTAQQRKCPEWMNVQNKRCAVEERKACVRKSVFEDDLPFLEFTGSIVYSYDASDCSFLSEDISMSLSDGDVVGFDMEWPPLYNRGKLGKVALIQLCVSESKCYLFHVSSMSVFPQGLKMLLENKAVKKAGVGIEGDQWKLLRDFDIKLKNFVELTDVANKKLKCTETWSLNSLVKHLLGKQLLKDKSIRCSNWSKFPLTEDQKLYAATDAYAGFIIYRNLEILDDTVQRFAINKEEEILLSDMNKQLTSISEEVMDLAKHLPHAFSKLENPRRVSILLKDISENLYSLRRMIIGSTNIETELRPSNNLNLLSFEDSTTGGVQQKQIREHEVLIHVEDETWDPTLDHLAKHDGEDVLGNKVERKEDGFEDGVEDNKLKENMERACLMSLDITEHELQILEQQSQEEYLSDIAYKSTEHLSPNDNENDTSYVIESDEDLEMEMLKHLSPNDNENDTSYVIESDEDLEMEMLKSLENLNSGTVEPTHSKCLKMERNLGLPTKEEEEDDENEANEGEEDDDKDFLWPAPNEEQVTCLKMYFGHSSFKPVQWKVIHSVLEERRDNVAVMATGYGKSLCFQYPPVYVGKIGLVISPLISLMEDQVLQLKMSNIPACFLGSAQSENVLTDIKLGKYRIVYVTPEYCSGNMGLLQQLEADIGITLIAVDEAHCISEWGHDFRDSFRKLGSLKTALPMVPIVALTATASSSIREDIVRCLNLRNPQITCTGFDRPNLYLEVRRKTGNILQDLQPFLVKTSSHWEFEGPTIIYCPSRKMTQQVTGELRKLNLSCGTYHAGMSFSTRKDIHHRFVRDEIQCVIATIAFGMGINKADIRQVIHYGAPKDMESYYQEIGRAGRDGLQSSCHVLWAPADINLNRHLLTEIRNEKFRLYKLKMMAKMEKYLHSSRCRRQIILSHFEDKQVQKASLGIMGTEKCCDNCRSRLDHCYSMDDSEDTSWDFGPQAFKLLSAVDILGEKFGIGLPILFLRGSNSQRLADQYRRHSLFGTGKDQTESWWKAFSRQLITEGFLVEVSRYNKFMKICALTKKGRNWLHKANTESQSLILQANEELCPKKLLLPSSKTVSSGTKEHCYNQVPVELSTEKKSNLEKLYSYKPCDKISSGSNISKKSIMVQSPEKAYSSSQPVISAQEQETQIVLYGKLVEARQKHANKMDVPPAILATNKILVDMAKMRPTTVENVKRIDGVSEGKAAMLAPLLEVIKHFCQTNSVQTDLFSSTKPQEEQKTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKISLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLMDKTKRGGLFS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEKKLETT ------CCHHHHHHH	70.22	22814378
4	Ubiquitination	----MSEKKLETTAQ ----CCHHHHHHHHH	72.46	24816145
5	Ubiquitination	---MSEKKLETTAQQ ---CCHHHHHHHHHH	47.72	29967540
14	Ubiquitination	ETTAQQRKCPEWMNV HHHHHHHCCHHHHCC	50.21	29967540
32	Acetylation	RCAVEERKACVRKSV CHHHHHHHHHHHHHH	49.79	19826841
131	Ubiquitination	LKMLLENKAVKKAGV HHHHHCCCCHHHCCC	45.22	29967540
135	Ubiquitination	LENKAVKKAGVGIEG HCCCCHHHCCCCCCC	43.72	29967540
146	Ubiquitination	GIEGDQWKLLRDFDI CCCCCCCCCHHHCCC	31.82	29967540
154	Ubiquitination	LLRDFDIKLKNFVEL CHHHCCCEECCEEEH	56.08	29967540
154	Sumoylation	LLRDFDIKLKNFVEL CHHHCCCEECCEEEH	56.08	28112733
167	Ubiquitination	ELTDVANKKLKCTET EHHHHCCCCCCCCCC	50.15	29967540
168	Ubiquitination	LTDVANKKLKCTETW HHHHCCCCCCCCCCC	53.65	-
172	Phosphorylation	ANKKLKCTETWSLNS CCCCCCCCCCCCHHH	34.56	26270265
174	Phosphorylation	KKLKCTETWSLNSLV CCCCCCCCCCHHHHH	11.38	26270265
176	Phosphorylation	LKCTETWSLNSLVKH CCCCCCCCHHHHHHH	25.70	26270265
179	Phosphorylation	TETWSLNSLVKHLLG CCCCCHHHHHHHHHC	39.57	26270265
187	Ubiquitination	LVKHLLGKQLLKDKS HHHHHHCHHHHCCCC	37.43	29967540
202	Ubiquitination	IRCSNWSKFPLTEDQ CCCCCCCCCCCCCCH	42.49	29967540
241	Sumoylation	VQRFAINKEEEILLS HHHHCCCHHHHHHHH	61.46	-
241	Ubiquitination	VQRFAINKEEEILLS HHHHCCCHHHHHHHH	61.46	22817900
241	Sumoylation	VQRFAINKEEEILLS HHHHCCCHHHHHHHH	61.46	28112733
248	Phosphorylation	KEEEILLSDMNKQLT HHHHHHHHHHHHHHH	31.22	-
252	Sumoylation	ILLSDMNKQLTSISE HHHHHHHHHHHHHCH	39.79	28112733
274	Ubiquitination	HLPHAFSKLENPRRV HHHHHHHCCCCHHHH	54.06	22505724
282	Phosphorylation	LENPRRVSILLKDIS CCCHHHHEEEEHHHH	13.00	23882029
286	Ubiquitination	RRVSILLKDISENLY HHHEEEEHHHHHHHH	49.96	-
294	Phosphorylation	DISENLYSLRRMIIG HHHHHHHHHHHHHHC	20.68	24719451
319	Phosphorylation	SNNLNLLSFEDSTTG CCCCCEEEEECCCCC	29.74	20516064
366	Acetylation	GEDVLGNKVERKEDG CCCCCCCCCEECCCC	43.61	20428248
366	Ubiquitination	GEDVLGNKVERKEDG CCCCCCCCCEECCCC	43.61	21906983
370	Ubiquitination	LGNKVERKEDGFEDG CCCCCEECCCCCCCC	46.80	22817900
382	Ubiquitination	EDGVEDNKLKENMER CCCCCCCHHHHHHHH	73.57	22817900
384	Ubiquitination	GVEDNKLKENMERAC CCCCCHHHHHHHHHH	48.96	22817900
409	Phosphorylation	LQILEQQSQEEYLSD HHHHHHHCHHHHHHH	38.97	28122231
413	Phosphorylation	EQQSQEEYLSDIAYK HHHCHHHHHHHHHHH	15.68	28122231
415	Phosphorylation	QSQEEYLSDIAYKST HCHHHHHHHHHHHCC	26.52	28122231
421	Phosphorylation	LSDIAYKSTEHLSPN HHHHHHHCCCCCCCC	26.76	30576142
422	Phosphorylation	SDIAYKSTEHLSPND HHHHHHCCCCCCCCC	24.23	19690332
426	Phosphorylation	YKSTEHLSPNDNEND HHCCCCCCCCCCCCC	24.46	22617229
434	Phosphorylation	PNDNENDTSYVIESD CCCCCCCCCEEEECC	33.27	30108239
435	Phosphorylation	NDNENDTSYVIESDE CCCCCCCCEEEECCH	21.92	30108239
436	Phosphorylation	DNENDTSYVIESDED CCCCCCCEEEECCHH	13.92	28450419
440	Phosphorylation	DTSYVIESDEDLEME CCCEEEECCHHHHHH	34.87	25159151
453	Phosphorylation	MEMLKHLSPNDNEND HHHHHHCCCCCCCCC	22.75	22617229
461	Phosphorylation	PNDNENDTSYVIESD CCCCCCCCCEEECCC	33.27	30108239
462	Phosphorylation	NDNENDTSYVIESDE CCCCCCCCEEECCCH	21.92	30108239
463	Phosphorylation	DNENDTSYVIESDED CCCCCCCEEECCCHH	13.92	28450419
467	Phosphorylation	DTSYVIESDEDLEME CCCEEECCCHHHHHH	34.87	22617229
478	Phosphorylation	LEMEMLKSLENLNSG HHHHHHHHHHCCCCC	36.63	30266825
484	Phosphorylation	KSLENLNSGTVEPTH HHHHCCCCCCCCCCH	38.72	28555341
486	Phosphorylation	LENLNSGTVEPTHSK HHCCCCCCCCCCHHH	22.86	23186163
490	Phosphorylation	NSGTVEPTHSKCLKM CCCCCCCCHHHHHHH	25.85	23917254
493	Acetylation	TVEPTHSKCLKMERN CCCCCHHHHHHHHHH	35.66	23749302
493	Ubiquitination	TVEPTHSKCLKMERN CCCCCHHHHHHHHHH	35.66	29967540
496	Sumoylation	PTHSKCLKMERNLGL CCHHHHHHHHHHCCC	48.46	-
496	Sumoylation	PTHSKCLKMERNLGL CCHHHHHHHHHHCCC	48.46	-
496	Ubiquitination	PTHSKCLKMERNLGL CCHHHHHHHHHHCCC	48.46	-
506	Ubiquitination	RNLGLPTKEEEEDDE HHCCCCCCCHHCCCC	62.28	29967540
543	Phosphorylation	QVTCLKMYFGHSSFK HEEEEEHHHCCCCCC	12.57	22798277
547	Phosphorylation	LKMYFGHSSFKPVQW EEHHHCCCCCCCCHH	37.54	22798277
559	Phosphorylation	VQWKVIHSVLEERRD CHHHHHHHHHHHCCC	19.78	22798277
612	Phosphorylation	QVLQLKMSNIPACFL HHHHHHHCCCCCHHC	29.98	24247654
624	Phosphorylation	CFLGSAQSENVLTDI HHCCCCCCCCCCCHH	30.75	24247654
629	Phosphorylation	AQSENVLTDIKLGKY CCCCCCCCHHHCCCE	31.25	24247654
689	Phosphorylation	DSFRKLGSLKTALPM HHHHHHCCHHHHCCC	36.81	-
692	Phosphorylation	RKLGSLKTALPMVPI HHHCCHHHHCCCCCE	38.43	24719451
707	Phosphorylation	VALTATASSSIREDI EHHEECCCHHHHHHH	21.92	24719451
757	Phosphorylation	LQPFLVKTSSHWEFE HHHEEEECCCCCCEE	28.16	23401153
758	Phosphorylation	QPFLVKTSSHWEFEG HHEEEECCCCCCEEC	17.94	23401153
759	Phosphorylation	PFLVKTSSHWEFEGP HEEEECCCCCCEECC	37.54	23401153
767	Phosphorylation	HWEFEGPTIIYCPSR CCCEECCEEEECCCC	30.75	23401153
770	Phosphorylation	FEGPTIIYCPSRKMT EECCEEEECCCCCCH	8.41	23401153
773	Phosphorylation	PTIIYCPSRKMTQQV CEEEECCCCCCHHHH	40.76	23401153
775	Ubiquitination	IIYCPSRKMTQQVTG EEECCCCCCHHHHHH	51.11	-
777	Phosphorylation	YCPSRKMTQQVTGEL ECCCCCCHHHHHHHH	20.91	-
790	Phosphorylation	ELRKLNLSCGTYHAG HHHHCCCCCCCEECC	14.93	-
801	Phosphorylation	YHAGMSFSTRKDIHH EECCCCCCCCCCHHH	21.72	-
849	Phosphorylation	PKDMESYYQEIGRAG CCCHHHHHHHHHHHC	14.67	-
856	Ubiquitination	YQEIGRAGRDGLQSS HHHHHHHCCCCCCCC	27.18	24816145
862	Phosphorylation	AGRDGLQSSCHVLWA HCCCCCCCCCEEEEE	39.72	20873877
863	Phosphorylation	GRDGLQSSCHVLWAP CCCCCCCCCEEEEEC	8.69	20873877
887	Acetylation	LTEIRNEKFRLYKLK HHHHHHHCHHHHHHH	39.06	20428248
905	Phosphorylation	KMEKYLHSSRCRRQI HHHHHHHCHHHHHHH	19.51	28152594
906	Phosphorylation	MEKYLHSSRCRRQII HHHHHHCHHHHHHHH	25.34	28152594
915	Phosphorylation	CRRQIILSHFEDKQV HHHHHHHHHCCCHHH	18.74	24719451
924	Ubiquitination	FEDKQVQKASLGIMG CCCHHHHHHHHCCCC	40.88	29967540
934	Ubiquitination	LGIMGTEKCCDNCRS HCCCCCHHHCHHHHH	39.75	-
948	Phosphorylation	SRLDHCYSMDDSEDT HHCCCCCCCCCCCCC	22.56	-
968	Phosphorylation	PQAFKLLSAVDILGE HHHHHHHHHHHHHHH	36.36	21406692
1002	Phosphorylation	ADQYRRHSLFGTGKD HHHHHHHCCCCCCCC	24.47	28555341
1036	Sumoylation	VEVSRYNKFMKICAL EEEHHHCCHHHHHHH	37.59	-
1036	Sumoylation	VEVSRYNKFMKICAL EEEHHHCCHHHHHHH	37.59	-
1058	Phosphorylation	LHKANTESQSLILQA HHHCCCCCHHHHHHC	24.03	17525332
1073	Ubiquitination	NEELCPKKLLLPSSK CHHHCCCCEECCCCC	29.52	29967540
1079	Phosphorylation	KKLLLPSSKTVSSGT CCEECCCCCCCCCCC	30.33	-
1080	Ubiquitination	KLLLPSSKTVSSGTK CEECCCCCCCCCCCC	58.23	29967540
1084	Phosphorylation	PSSKTVSSGTKEHCY CCCCCCCCCCCCHHC	46.26	-
1087	Ubiquitination	KTVSSGTKEHCYNQV CCCCCCCCCHHCCCC	49.32	29967540
1099	Phosphorylation	NQVPVELSTEKKSNL CCCCCCCCCCCCCCH	22.48	25627689
1100	Phosphorylation	QVPVELSTEKKSNLE CCCCCCCCCCCCCHH	65.53	25159151
1102	Ubiquitination	PVELSTEKKSNLEKL CCCCCCCCCCCHHHH	62.68	29967540
1103	Ubiquitination	VELSTEKKSNLEKLY CCCCCCCCCCHHHHH	38.04	-
1110	Phosphorylation	KSNLEKLYSYKPCDK CCCHHHHHCCCCCCC	22.48	-
1111	Phosphorylation	SNLEKLYSYKPCDKI CCHHHHHCCCCCCCC	36.80	-
1112	Phosphorylation	NLEKLYSYKPCDKIS CHHHHHCCCCCCCCC	12.85	18452278
1113	Acetylation	LEKLYSYKPCDKISS HHHHHCCCCCCCCCC	32.98	25953088
1117	Acetylation	YSYKPCDKISSGSNI HCCCCCCCCCCCCCC	51.72	20428248
1120	Phosphorylation	KPCDKISSGSNISKK CCCCCCCCCCCCCCC	50.11	18452278
1126	Acetylation	SSGSNISKKSIMVQS CCCCCCCCCEEEECC	46.90	25953088
1127	Acetylation	SGSNISKKSIMVQSP CCCCCCCCEEEECCH	38.12	20428248
1128	Phosphorylation	GSNISKKSIMVQSPE CCCCCCCEEEECCHH	21.47	28450419
1133	Phosphorylation	KKSIMVQSPEKAYSS CCEEEECCHHHHCCC	24.50	19664994
1138	Phosphorylation	VQSPEKAYSSSQPVI ECCHHHHCCCCCCCC	21.83	28464451
1139	Phosphorylation	QSPEKAYSSSQPVIS CCHHHHCCCCCCCCC	28.51	28122231
1140	Phosphorylation	SPEKAYSSSQPVISA CHHHHCCCCCCCCCH	21.95	28122231
1141	Phosphorylation	PEKAYSSSQPVISAQ HHHHCCCCCCCCCHH	32.34	17525332
1157	Phosphorylation	QETQIVLYGKLVEAR HCCEEHHHHHHHHHH	11.00	24260401
1170	Ubiquitination	ARQKHANKMDVPPAI HHHHHHHCCCCCHHH	36.94	29967540
1189	Ubiquitination	KILVDMAKMRPTTVE CCHHHHHHCCCCCHH	28.89	-
1199	Ubiquitination	PTTVENVKRIDGVSE CCCHHHCCCCCCCCH	56.04	29967540
1205	Phosphorylation	VKRIDGVSEGKAAML CCCCCCCCHHHHHHH	46.27	-
1249	Acetylation	QKTSLVAKNKICTLS HHHCHHHHCCCCHHH	51.82	25953088
1270	Ubiquitination	YSLFQEKKMPLKSIA HHHHHCCCCCHHHHH	45.02	-
1274	Acetylation	QEKKMPLKSIAESRI HCCCCCHHHHHHHCH	33.67	12650359
1275	Phosphorylation	EKKMPLKSIAESRIL CCCCCHHHHHHHCHH	34.41	29083192
1279	Phosphorylation	PLKSIAESRILPLMT CHHHHHHHCHHHHHH	18.65	29083192
1286	Phosphorylation	SRILPLMTIGMHLSQ HCHHHHHHHHHHHHH	23.28	29083192
1292	Phosphorylation	MTIGMHLSQAVKAGC HHHHHHHHHHHHCCC	11.04	29083192
1314	Ubiquitination	GLTPEVQKIIADVIR CCCHHHHHHHHHHHH	41.05	29967540
1327	Phosphorylation	IRNPPVNSDMSKISL HHCCCCCCCCCHHHH	34.62	21406692
1330	Phosphorylation	PPVNSDMSKISLIRM CCCCCCCCHHHHHHH	31.65	20860994
1331	Ubiquitination	PVNSDMSKISLIRML CCCCCCCHHHHHHHH	29.67	-
1333	Phosphorylation	NSDMSKISLIRMLVP CCCCCHHHHHHHHCC	22.83	21406692
1362	Ubiquitination	LKHGPDSGLQPSCDV HHHCCCCCCCCCCCC	35.39	24816145
1371	Ubiquitination	QPSCDVNKRRCFPGS CCCCCCCCCCCCCCC	40.86	29967540
1371	Acetylation	QPSCDVNKRRCFPGS CCCCCCCCCCCCCCC	40.86	25953088
1378	Phosphorylation	KRRCFPGSEEICSSS CCCCCCCCHHHHCCC	32.09	-
1385	Phosphorylation	SEEICSSSKRSKEEV CHHHHCCCCCCHHHH	18.78	25627689
1386	Ubiquitination	EEICSSSKRSKEEVG HHHHCCCCCCHHHHC	63.74	29967540
1388	Phosphorylation	ICSSSKRSKEEVGIN HHCCCCCCHHHHCCC	48.43	24719451
1389	Acetylation	CSSSKRSKEEVGINT HCCCCCCHHHHCCCC	63.02	20428248
1389	Ubiquitination	CSSSKRSKEEVGINT HCCCCCCHHHHCCCC	63.02	24816145
1396	Phosphorylation	KEEVGINTETSSAER HHHHCCCCCCCCHHH	38.43	24732914
1398	Phosphorylation	EVGINTETSSAERKR HHCCCCCCCCHHHHH	26.41	24732914
1399	Phosphorylation	VGINTETSSAERKRR HCCCCCCCCHHHHHC	22.71	24732914
1400	Phosphorylation	GINTETSSAERKRRL CCCCCCCCHHHHHCC	41.38	20159463
1413	Acetylation	RLPVWFAKGSDTSKK CCCEEEECCCHHHHH	49.85	20428248
1415	Phosphorylation	PVWFAKGSDTSKKLM CEEEECCCHHHHHHH	36.69	23403867
1417	Phosphorylation	WFAKGSDTSKKLMDK EEECCCHHHHHHHHH	44.11	23403867
1418	Phosphorylation	FAKGSDTSKKLMDKT EECCCHHHHHHHHHH	32.55	23403867
1427	Methylation	KLMDKTKRGGLFS-- HHHHHHCCCCCCC--	50.04	115386503
1432	Phosphorylation	TKRGGLFS------- HCCCCCCC-------	44.34	27134283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
319	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
440	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
467	S	Phosphorylation	Kinase	PRKDC	P78527	GPS
1133	S	Phosphorylation	Kinase	CDK2	P24941	PSP
1141	S	Phosphorylation	Kinase	ATM	Q13315	PSP
1141	S	Phosphorylation	Kinase	ATR	Q13535	PSP
1292	S	Phosphorylation	Kinase	ATM	Q13315	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WRN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
1126	Acetylation	1133 (7)	S ⇒ A	rs11574358	Lifespan	25918517
1127	Acetylation	1133 (6)	S ⇒ A	rs11574358	Lifespan	25918517
1128	Phosphorylation	1133 (5)	S ⇒ A	rs11574358	Lifespan	25918517
1133	Phosphorylation	1133 (0)	S ⇒ A	rs11574358	Lifespan	25918517
1138	Phosphorylation	1133 (5)	S ⇒ A	rs11574358	Lifespan	25918517
1141	Phosphorylation	1133 (8)	S ⇒ A	rs11574358	Lifespan	25918517

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FEN1_HUMAN	FEN1	physical	14688284
TERF2_HUMAN	TERF2	physical	12181313
PCNA_HUMAN	PCNA	physical	12633936
PRKDC_HUMAN	PRKDC	physical	11889123
WRIP1_HUMAN	WRNIP1	physical	11301316
XRCC5_HUMAN	XRCC5	physical	12177300
XRCC6_HUMAN	XRCC6	physical	12177300
P53_HUMAN	TP53	physical	12080066
XRCC6_HUMAN	XRCC6	physical	10880505
XRCC5_HUMAN	XRCC5	physical	10880505
EXO1_YEAST	EXO1	physical	20447876
CAF1A_HUMAN	CHAF1A	physical	17173071
POTE1_HUMAN	POT1	genetic	21098121
FEN1_HUMAN	FEN1	physical	16326861
H2AX_HUMAN	H2AFX	physical	15733840
NBN_HUMAN	NBN	physical	15733840
DHX9_HUMAN	DHX9	physical	17498979
RAD51_HUMAN	RAD51	physical	17118963
RAD52_HUMAN	RAD52	physical	17118963
NBN_HUMAN	NBN	physical	20600238
PCNA_HUMAN	PCNA	physical	20600238
WRN_HUMAN	WRN	physical	10783163
XRCC6_HUMAN	XRCC6	physical	10783163
XRCC5_HUMAN	XRCC5	physical	10783163
XRCC5_HUMAN	XRCC5	physical	11328876
PARP1_HUMAN	PARP1	physical	14734561
XRCC5_HUMAN	XRCC5	physical	14734561
XRCC6_HUMAN	XRCC6	physical	14734561
ATR_HUMAN	ATR	physical	22159421
DHX9_HUMAN	DHX9	physical	15995249
TERA_HUMAN	VCP	physical	12937274
XRCC5_HUMAN	XRCC5	physical	12937274
CDN2A_HUMAN	CDKN2A	physical	15355988
ARF_HUMAN	CDKN2A	physical	15355988
CDC5L_HUMAN	CDC5L	physical	16223718
PML_HUMAN	PML	physical	21639834
TERA_HUMAN	VCP	physical	15037256
RAD52_HUMAN	RAD52	physical	12750383
SIR1_HUMAN	SIRT1	physical	18203716
CBP_HUMAN	CREBBP	physical	18203716

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
277700	Werner syndrome (WRN)
114500	Colorectal cancer (CRC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WRN_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426; SER-467 ANDSER-1133, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1133, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-453 AND SER-467, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1058 AND SER-1141, ANDMASS SPECTROMETRY.	17525332 [Abstract]