| UniProt ID | EXO1_YEAST | |
|---|---|---|
| UniProt AC | P39875 | |
| Protein Name | Exodeoxyribonuclease 1 | |
| Gene Name | EXO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 702 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | 5'->3' double-stranded DNA exonuclease involved in mismatch repair and eventually also in mitotic recombination between direct repeats. Also has a minor role in the correction of large DNA mismatches that occur in the heteroduplex DNA during meiotic recombination at the HIS4 locus.. | |
| Protein Sequence | MGIQGLLPQLKPIQNPVSLRRYEGEVLAIDGYAWLHRAACSCAYELAMGKPTDKYLQFFIKRFSLLKTFKVEPYLVFDGDAIPVKKSTESKRRDKRKENKAIAERLWACGEKKNAMDYFQKCVDITPEMAKCIICYCKLNGIRYIVAPFEADSQMVYLEQKNIVQGIISEDSDLLVFGCRRLITKLNDYGECLEICRDNFIKLPKKFPLGSLTNEEIITMVCLSGCDYTNGIPKVGLITAMKLVRRFNTIERIILSIQREGKLMIPDTYINEYEAAVLAFQFQRVFCPIRKKIVSLNEIPLYLKDTESKRKRLYACIGFVIHRETQKKQIVHFDDDIDHHLHLKIAQGDLNPYDFHQPLANREHKLQLASKSNIEFGKTNTTNSEAKVKPIESFFQKMTKLDHNPKVANNIHSLRQAEDKLTMAIKRRKLSNANVVQETLKDTRSKFFNKPSMTVVENFKEKGDSIQDFKEDTNSQSLEEPVSESQLSTQIPSSFITTNLEDDDNLSEEVSEVVSDIEEDRKNSEGKTIGNEIYNTDDDGDGDTSEDYSETAESRVPTSSTTSFPGSSQRSISGCTKVLQKFRYSSSFSGVNANRQPLFPRHVNQKSRGMVYVNQNRDDDCDDNDGKNQITQRPSLRKSLIGARSQRIVIDMKSVDERKSFNSSPILHEESKKRDIETTKSSQARPAVRSISLLSQFVYKGK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 372 | Phosphorylation | KLQLASKSNIEFGKT HHHHHHHCCCCCCCC | 40.31 | 17563356 | |
| 413 | Phosphorylation | KVANNIHSLRQAEDK HHHHHHHHHHHHHHH | 22.81 | 30377154 | |
| 431 | Phosphorylation | AIKRRKLSNANVVQE HHHHHCCCCCCHHHH | 36.61 | 28889911 | |
| 563 | Phosphorylation | VPTSSTTSFPGSSQR CCCCCCCCCCCCCCC | 29.54 | 28889911 | |
| 567 | Phosphorylation | STTSFPGSSQRSISG CCCCCCCCCCCCCCC | 24.44 | 28889911 | |
| 586 | Phosphorylation | LQKFRYSSSFSGVNA HHHHCCCCCCCCCCC | 26.86 | 30377154 | |
| 587 | Phosphorylation | QKFRYSSSFSGVNAN HHHCCCCCCCCCCCC | 19.93 | 18756267 | |
| 638 | Acetylation | TQRPSLRKSLIGARS HCCHHHHHHHHCCCC | 55.71 | 25381059 | |
| 660 | Phosphorylation | KSVDERKSFNSSPIL CCHHHHHCCCCCCCC | 35.56 | 30377154 | |
| 663 | Phosphorylation | DERKSFNSSPILHEE HHHHCCCCCCCCCHH | 35.17 | 30377154 | |
| 680 | Acetylation | KRDIETTKSSQARPA HCCCCCCCHHHHCHH | 56.37 | 25381059 | |
| 692 | Phosphorylation | RPAVRSISLLSQFVY CHHHHHHHHHHHHHH | 25.22 | 18756267 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EXO1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EXO1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EXO1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372 AND SER-563, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372, AND MASSSPECTROMETRY. | |
