| UniProt ID | RAD5_YEAST | |
|---|---|---|
| UniProt AC | P32849 | |
| Protein Name | DNA repair protein RAD5 | |
| Gene Name | RAD5 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1169 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with the DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs. Recruits the UBC13-MMS2 dimer to chromatin for DNA repair.. | |
| Protein Sequence | MSHIEQEERKRFFNDDLDTSETSLNFKSENKESFLFANSHNDDDDDVVVSVSDTTEGEGDRSIVPVRREIEEEGQNQFITELLRIIPEMPKDLVMELNEKFGSQEEGLSLALSHYFDHNSGTSISKIPSSPNQLNTLSDTSNSTLSPSSFHPKRRRIYGFRNQTRLEDKVTWKRFIGALQVTGMATRPTVRPLKYGSQMKLKRSSEEISATKVYDSRGRKKASMASLVRIFDIQYDREIGRVSEDIAQILYPLLSSHEISFEVTLIFCDNKRLSIGDSFILQLDCFLTSLIFEERNDGESLMKRRRTEGGNKREKDNGNFGRTLTETDEELESRSKRLALLKLFDKLRLKPILDEQKALEKHKIELNSDPEIIDLDNDEICSNQVTEVHNNLRDTQHEEETMNLNQLKTFYKAAQSSESLKSLPETEPSRDVFKLELRNYQKQGLTWMLRREQEFAKAASDGEASETGANMINPLWKQFKWPNDMSWAAQNLQQDHVNVEDGIFFYANLHSGEFSLAKPILKTMIKGGILSDEMGLGKTVAAYSLVLSCPHDSDVVDKKLFDIENTAVSDNLPSTWQDNKKPYASKTTLIVVPMSLLTQWSNEFTKANNSPDMYHEVYYGGNVSSLKTLLTKTKTPPTVVLTTYGIVQNEWTKHSKGRMTDEDVNISSGLFSVNFYRIIIDEGHNIRNRTTVTSKAVMALQGKCKWVLTGTPIINRLDDLYSLVKFLELDPWRQINYWKTFVSTPFESKNYKQAFDVVNAILEPVLLRRTKQMKDKDGKPLVELPPKEVVIKRLPFSKSQDLLYKFLLDKAEVSVKSGIARGDLLKKYSTILVHILRLRQVCCHPGLIGSQDENDEDLSKNNKLVTEQTVELDSLMRVVSERFDNSFSKEELDAMIQRLKVKYPDNKSFQSLECSICTTEPMDLDKALFTECGHSFCEKCLFEYIEFQNSKNLGLKCPNCRNQIDACRLLALVQTNSNSKNLEFKPYSPASKSSKITALLKELQLLQDSSAGEQVVIFSQFSTYLDILEKELTHTFSKDVAKIYKFDGRLSLKERTSVLADFAVKDYSRQKILLLSLKAGGVGLNLTCASHAYMMDPWWSPSMEDQAIDRLHRIGQTNSVKVMRFIIQDSIEEKMLRIQEKKRTIGEAMDTDEDERRKRRIEEIQMLFE | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSHIEQEER ------CCCCCHHHH | 44.47 | 22814378 | |
| 2 | Phosphorylation | ------MSHIEQEER ------CCCCCHHHH | 44.47 | 30377154 | |
| 19 | Phosphorylation | FFNDDLDTSETSLNF HCCCCCCCCCCCCCC | 35.44 | 20377248 | |
| 20 | Phosphorylation | FNDDLDTSETSLNFK CCCCCCCCCCCCCCC | 38.25 | 20377248 | |
| 22 | Phosphorylation | DDLDTSETSLNFKSE CCCCCCCCCCCCCCC | 37.98 | 20377248 | |
| 23 | Phosphorylation | DLDTSETSLNFKSEN CCCCCCCCCCCCCCC | 19.77 | 19823750 | |
| 129 | Phosphorylation | TSISKIPSSPNQLNT CCCCCCCCCCCCCCC | 63.00 | 21551504 | |
| 130 | Phosphorylation | SISKIPSSPNQLNTL CCCCCCCCCCCCCCC | 23.63 | 10880451 | |
| 136 | Phosphorylation | SSPNQLNTLSDTSNS CCCCCCCCCCCCCCC | 35.91 | 19779198 | |
| 138 | Phosphorylation | PNQLNTLSDTSNSTL CCCCCCCCCCCCCCC | 36.48 | 21440633 | |
| 140 | Phosphorylation | QLNTLSDTSNSTLSP CCCCCCCCCCCCCCH | 26.82 | 19779198 | |
| 141 | Phosphorylation | LNTLSDTSNSTLSPS CCCCCCCCCCCCCHH | 33.50 | 19779198 | |
| 143 | Phosphorylation | TLSDTSNSTLSPSSF CCCCCCCCCCCHHHC | 30.41 | 20377248 | |
| 144 | Phosphorylation | LSDTSNSTLSPSSFH CCCCCCCCCCHHHCC | 35.19 | 28889911 | |
| 146 | Phosphorylation | DTSNSTLSPSSFHPK CCCCCCCCHHHCCCC | 23.87 | 20377248 | |
| 148 | Phosphorylation | SNSTLSPSSFHPKRR CCCCCCHHHCCCCCC | 42.11 | 21551504 | |
| 149 | Phosphorylation | NSTLSPSSFHPKRRR CCCCCHHHCCCCCCE | 30.84 | 28889911 | |
| 323 | Phosphorylation | DNGNFGRTLTETDEE CCCCCCCCCCCCHHH | 38.11 | 30377154 | |
| 368 | Phosphorylation | KHKIELNSDPEIIDL HHCCCCCCCCCEECC | 68.14 | 19779198 | |
| 419 | Phosphorylation | KAAQSSESLKSLPET HHHHCCHHHHCCCCC | 42.94 | 28889911 | |
| 460 | Phosphorylation | QEFAKAASDGEASET HHHHHHHCCCCCCHH | 51.51 | 26447709 | |
| 465 | Phosphorylation | AASDGEASETGANMI HHCCCCCCHHHHHCC | 31.24 | 26447709 | |
| 467 | Phosphorylation | SDGEASETGANMINP CCCCCCHHHHHCCCH | 38.81 | 26447709 | |
| 585 | Phosphorylation | DNKKPYASKTTLIVV CCCCCCCCCEEEEEE | 25.37 | 30377154 | |
| 587 | Phosphorylation | KKPYASKTTLIVVPM CCCCCCCEEEEEEEH | 25.08 | 30377154 | |
| 588 | Phosphorylation | KPYASKTTLIVVPMS CCCCCCEEEEEEEHH | 20.44 | 30377154 | |
| 595 | Phosphorylation | TLIVVPMSLLTQWSN EEEEEEHHHHHHHHH | 17.73 | 30377154 | |
| 601 | Phosphorylation | MSLLTQWSNEFTKAN HHHHHHHHHHHHHHC | 19.36 | 30377154 | |
| 690 | Phosphorylation | GHNIRNRTTVTSKAV CCCCCCCCCCCHHHH | 29.21 | 27017623 | |
| 691 | Phosphorylation | HNIRNRTTVTSKAVM CCCCCCCCCCHHHHH | 20.67 | 27017623 | |
| 693 | Phosphorylation | IRNRTTVTSKAVMAL CCCCCCCCHHHHHHH | 23.55 | 27017623 | |
| 798 | Acetylation | IKRLPFSKSQDLLYK EEECCCCCCHHHHHH | 53.14 | 24489116 | |
| 985 | Acetylation | NSKNLEFKPYSPASK CCCCCEECCCCCCCH | 33.40 | 24489116 | |
| 1044 | Phosphorylation | SKDVAKIYKFDGRLS CCCHHHHHEECCCCC | 12.61 | 25533186 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RAD5_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RAD5_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23; SER-129 AND SER-130,AND MASS SPECTROMETRY. | |
