| UniProt ID | VPS1_YEAST | |
|---|---|---|
| UniProt AC | P21576 | |
| Protein Name | Vacuolar protein sorting-associated protein 1 | |
| Gene Name | VPS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 704 | |
| Subcellular Localization | Cytoplasm, cytoskeleton . | |
| Protein Description | Essential for protein sorting in meiotic cell division of Saccharomyces cerevisiae; it binds microtubules. Could also be involved in microtubule-associated motility. Necessary for membrane protein retention in a late Golgi compartment. Interacts with the MVP1 protein.. | |
| Protein Sequence | MDEHLISTINKLQDALAPLGGGSQSPIDLPQITVVGSQSSGKSSVLENIVGRDFLPRGTGIVTRRPLVLQLINRRPKKSEHAKVNQTANELIDLNINDDDKKKDESGKHQNEGQSEDNKEEWGEFLHLPGKKFYNFDEIRKEIVKETDKVTGANSGISSVPINLRIYSPHVLTLTLVDLPGLTKVPVGDQPPDIERQIKDMLLKYISKPNAIILSVNAANTDLANSDGLKLAREVDPEGTRTIGVLTKVDLMDQGTDVIDILAGRVIPLRYGYIPVINRGQKDIEHKKTIREALENERKFFENHPSYSSKAHYCGTPYLAKKLNSILLHHIRQTLPEIKAKIEATLKKYQNELINLGPETMDSASSVVLSMITDFSNEYAGILDGEAKELSSQELSGGARISYVFHETFKNGVDSLDPFDQIKDSDIRTIMYNSSGSAPSLFVGTEAFEVLVKQQIRRFEEPSLRLVTLVFDELVRMLKQIISQPKYSRYPALREAISNQFIQFLKDATIPTNEFVVDIIKAEQTYINTAHPDLLKGSQAMVMVEEKLHPRQVAVDPKTGKPLPTQPSSSKAPVMEEKSGFFGGFFSTKNKKKLAALESPPPVLKATGQMTERETMETEVIKLLISSYFSIVKRTIADIIPKALMLKLIVKSKTDIQKVLLEKLYGKQDIEELTKENDITIQRRKECKKMVEILRNASQIVSSV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 7 | Phosphorylation | -MDEHLISTINKLQD -CCHHHHHHHHHHHH | 29.60 | 30377154 | |
| 8 | Phosphorylation | MDEHLISTINKLQDA CCHHHHHHHHHHHHH | 22.90 | 30377154 | |
| 101 | Acetylation | LNINDDDKKKDESGK CCCCCCCCCCCCCCC | 69.58 | 24489116 | |
| 119 | Acetylation | EGQSEDNKEEWGEFL CCCCCCCHHHHHHHH | 70.14 | 24489116 | |
| 132 | Acetylation | FLHLPGKKFYNFDEI HHCCCCCCCCCHHHH | 60.02 | 24489116 | |
| 145 | Acetylation | EIRKEIVKETDKVTG HHHHHHHHHHCCCCC | 61.63 | 24489116 | |
| 149 | Acetylation | EIVKETDKVTGANSG HHHHHHCCCCCCCCC | 49.46 | 24489116 | |
| 155 | Phosphorylation | DKVTGANSGISSVPI CCCCCCCCCCCCCCE | 36.65 | 30377154 | |
| 199 | Acetylation | PDIERQIKDMLLKYI CCHHHHHHHHHHHHH | 28.84 | 24489116 | |
| 310 | Acetylation | NHPSYSSKAHYCGTP CCCCCCCCCCCCCCH | 32.99 | 24489116 | |
| 321 | Acetylation | CGTPYLAKKLNSILL CCCHHHHHHHHHHHH | 56.02 | 24489116 | |
| 341 | Acetylation | TLPEIKAKIEATLKK HHHHHHHHHHHHHHH | 35.76 | 24489116 | |
| 391 | Phosphorylation | DGEAKELSSQELSGG CCCHHCCCCCCCCCC | 30.94 | 24909858 | |
| 392 | Phosphorylation | GEAKELSSQELSGGA CCHHCCCCCCCCCCC | 40.05 | 27214570 | |
| 396 | Phosphorylation | ELSSQELSGGARISY CCCCCCCCCCCCEEE | 34.13 | 30377154 | |
| 423 | Acetylation | LDPFDQIKDSDIRTI CCHHHHCCCCCCCEE | 45.61 | 24489116 | |
| 423 | Ubiquitination | LDPFDQIKDSDIRTI CCHHHHCCCCCCCEE | 45.61 | 23749301 | |
| 479 | Acetylation | DELVRMLKQIISQPK HHHHHHHHHHHCCCC | 30.06 | 24489116 | |
| 547 | Acetylation | AMVMVEEKLHPRQVA EEEEEECCCCCCCEE | 38.29 | 24489116 | |
| 558 | Acetylation | RQVAVDPKTGKPLPT CCEEECCCCCCCCCC | 66.50 | 24489116 | |
| 561 | Ubiquitination | AVDPKTGKPLPTQPS EECCCCCCCCCCCCC | 48.92 | 23749301 | |
| 568 | Phosphorylation | KPLPTQPSSSKAPVM CCCCCCCCCCCCCCC | 37.11 | 21440633 | |
| 569 | Phosphorylation | PLPTQPSSSKAPVME CCCCCCCCCCCCCCC | 42.41 | 27214570 | |
| 570 | Phosphorylation | LPTQPSSSKAPVMEE CCCCCCCCCCCCCCC | 36.86 | 23749301 | |
| 571 | Ubiquitination | PTQPSSSKAPVMEEK CCCCCCCCCCCCCCC | 59.67 | 23749301 | |
| 578 | Ubiquitination | KAPVMEEKSGFFGGF CCCCCCCCCCCCCCC | 42.44 | 23749301 | |
| 579 | Phosphorylation | APVMEEKSGFFGGFF CCCCCCCCCCCCCCC | 44.08 | 22369663 | |
| 587 | Phosphorylation | GFFGGFFSTKNKKKL CCCCCCCCCCCHHHH | 35.89 | 21440633 | |
| 589 | Acetylation | FGGFFSTKNKKKLAA CCCCCCCCCHHHHHH | 66.62 | 24489116 | |
| 599 | Phosphorylation | KKLAALESPPPVLKA HHHHHHCCCCCCHHH | 43.48 | 22369663 | |
| 605 | Ubiquitination | ESPPPVLKATGQMTE CCCCCCHHHCCCCCC | 44.10 | 24961812 | |
| 611 | Phosphorylation | LKATGQMTERETMET HHHCCCCCCHHHHHH | 24.81 | 28889911 | |
| 615 | Phosphorylation | GQMTERETMETEVIK CCCCCHHHHHHHHHH | 26.91 | 30377154 | |
| 618 | Phosphorylation | TERETMETEVIKLLI CCHHHHHHHHHHHHH | 25.40 | 30377154 | |
| 630 | Phosphorylation | LLISSYFSIVKRTIA HHHHHHHHHHHHHHH | 20.45 | 30377154 | |
| 651 | 2-Hydroxyisobutyrylation | LMLKLIVKSKTDIQK HHHHHHHCCCCHHHH | 38.96 | - | |
| 653 | 2-Hydroxyisobutyrylation | LKLIVKSKTDIQKVL HHHHHCCCCHHHHHH | 44.49 | - | |
| 658 | Acetylation | KSKTDIQKVLLEKLY CCCCHHHHHHHHHHH | 34.87 | 24489116 | |
| 663 | Acetylation | IQKVLLEKLYGKQDI HHHHHHHHHHCCCCH | 47.15 | 24489116 | |
| 667 | Acetylation | LLEKLYGKQDIEELT HHHHHHCCCCHHHHH | 31.10 | 24489116 | |
| 667 | Ubiquitination | LLEKLYGKQDIEELT HHHHHHCCCCHHHHH | 31.10 | 23749301 | |
| 675 | Acetylation | QDIEELTKENDITIQ CCHHHHHHHCCCCHH | 68.12 | 24489116 | |
| 688 | Acetylation | IQRRKECKKMVEILR HHHHHHHHHHHHHHH | 45.02 | 25381059 | |
| 689 | Acetylation | QRRKECKKMVEILRN HHHHHHHHHHHHHHH | 60.89 | 25381059 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-579 AND SER-599, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-599, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-599, AND MASSSPECTROMETRY. | |
