| UniProt ID | NCS1_YEAST | |
|---|---|---|
| UniProt AC | Q06389 | |
| Protein Name | Calcium-binding protein NCS-1 | |
| Gene Name | FRQ1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 190 | |
| Subcellular Localization |
Bud membrane Peripheral membrane protein . Buds and bud scars. |
|
| Protein Description | Regulator of phosphatidylinositol 4-kinase PIK1.. | |
| Protein Sequence | MGAKTSKLSKDDLTCLKQSTYFDRREIQQWHKGFLRDCPSGQLAREDFVKIYKQFFPFGSPEDFANHLFTVFDKDNNGFIHFEEFITVLSTTSRGTLEEKLSWAFELYDLNHDGYITFDEMLTIVASVYKMMGSMVTLNEDEATPEMRVKKIFKLMDKNEDGYITLDEFREGSKVDPSIIGALNLYDGLI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | N-myristoyl glycine | ------MGAKTSKLS ------CCCCCCCCC | 35.46 | - | |
| 2 | Myristoylation | ------MGAKTSKLS ------CCCCCCCCC | 35.46 | 10559922 | |
| 10 | Acetylation | AKTSKLSKDDLTCLK CCCCCCCHHHCHHHH | 66.74 | 24489116 | |
| 32 | Acetylation | REIQQWHKGFLRDCP HHHHHHHHHHHHCCC | 48.69 | 24489116 | |
| 134 | Phosphorylation | SVYKMMGSMVTLNED HHHHHHCCCEECCCC | 7.68 | 27017623 | |
| 137 | Phosphorylation | KMMGSMVTLNEDEAT HHHCCCEECCCCCCC | 18.41 | 29136822 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NCS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NCS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NCS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Myristoylation | |
| Reference | PubMed |
| "Yeast homologue of neuronal frequenin is a regulator ofphosphatidylinositol-4-OH kinase."; Hendricks K.B., Wang B.Q., Schnieders E.A., Thorner J.; Nat. Cell Biol. 1:234-241(1999). Cited for: FUNCTION, INTERACTION WITH PIK1, MUTAGENESIS OF GLY-2, ANDMYRISTOYLATION AT GLY-2. | |
