| UniProt ID | PIK1_YEAST | |
|---|---|---|
| UniProt AC | P39104 | |
| Protein Name | Phosphatidylinositol 4-kinase PIK1 | |
| Gene Name | PIK1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1066 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate. PIK1 is part of a nuclear phosphoinositide cycle and could control cytokinesis through the actin cytoskeleton.. | |
| Protein Sequence | MHKASSSKKSFDDTIELKKNEQLLKLINSSEFTLHNCVELLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMETESMALEDLLLRLRAENPHFALLTFWQLQALLTDLSTDPASYGFQVARRVLNNLQTNLFNTSSGSDKNVKIHENVAPALVLSSMIMSAIAFPQLSEVTKPLVESQGRRQKAFVFKLARSAMKDFTKNMTLKNTLLNKKTSRSKRVSSNRSSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDIVDDIGNQVFEERISSSIKLPKRKPKYLDNSYVHRTYDGKNINRDGSISNTAKALDGNKGDYISPKGRNDENNEIGNNEDETGGETEEDADALNSDHFTSSMPDLHNIQPRTSSASSASLEGTPKLNRTNSQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTITANEAQVLNSAEKVPYLLLIEYLRDEFDFDPTSETNERLLKKISGNQGGLIFDLNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEEDLGDMSMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSKNIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKFGYHDLEALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIKKALTKKMIEDAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNEGHVSHIDFGFMLSNSPGSVGFEAAPFKLTYEYIELLGGVEGEAFKKFVELTKSSFKALRKYADQIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFVENFLIGKSLGSIYTRIYDQFQLITQGIYS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MHKASSSKKSFD ---CCCCCCCCCCCC | 39.69 | 24961812 | |
| 6 | Phosphorylation | --MHKASSSKKSFDD --CCCCCCCCCCCCC | 51.54 | 24961812 | |
| 7 | Phosphorylation | -MHKASSSKKSFDDT -CCCCCCCCCCCCCC | 41.42 | 21440633 | |
| 10 | Phosphorylation | KASSSKKSFDDTIEL CCCCCCCCCCCCCHH | 37.33 | 22369663 | |
| 14 | Phosphorylation | SKKSFDDTIELKKNE CCCCCCCCCHHHHHH | 20.42 | 19823750 | |
| 200 | Phosphorylation | FVFKLARSAMKDFTK HHHHHHHHHCHHHHH | 27.40 | 27017623 | |
| 227 | Phosphorylation | TSRSKRVSSNRSSTP CCCCCCCCCCCCCCC | 26.40 | 19823750 | |
| 228 | Phosphorylation | SRSKRVSSNRSSTPT CCCCCCCCCCCCCCC | 33.15 | 20377248 | |
| 231 | Phosphorylation | KRVSSNRSSTPTSPI CCCCCCCCCCCCCCC | 42.70 | 17330950 | |
| 232 | Phosphorylation | RVSSNRSSTPTSPID CCCCCCCCCCCCCCC | 34.86 | 19823750 | |
| 233 | Phosphorylation | VSSNRSSTPTSPIDL CCCCCCCCCCCCCCC | 31.65 | 25521595 | |
| 235 | Phosphorylation | SNRSSTPTSPIDLID CCCCCCCCCCCCCCC | 47.42 | 25521595 | |
| 236 | Phosphorylation | NRSSTPTSPIDLIDP CCCCCCCCCCCCCCC | 22.51 | 25521595 | |
| 245 | Ubiquitination | IDLIDPIKTKEDASF CCCCCCCCCHHCCCC | 59.96 | 24961812 | |
| 282 | Phosphorylation | FEERISSSIKLPKRK HHHHHHHCCCCCCCC | 19.56 | 23749301 | |
| 312 | Phosphorylation | KNINRDGSISNTAKA CCCCCCCCCCCCHHH | 27.42 | 25521595 | |
| 314 | Phosphorylation | INRDGSISNTAKALD CCCCCCCCCCHHHHC | 29.80 | 24961812 | |
| 329 | Phosphorylation | GNKGDYISPKGRNDE CCCCCCCCCCCCCCC | 17.84 | 21440633 | |
| 366 | Phosphorylation | NSDHFTSSMPDLHNI CCCCCCCCCCCHHCC | 31.14 | 27017623 | |
| 377 | Phosphorylation | LHNIQPRTSSASSAS HHCCCCCCCCCCCCC | 33.44 | 22369663 | |
| 378 | Phosphorylation | HNIQPRTSSASSASL HCCCCCCCCCCCCCC | 25.78 | 22369663 | |
| 379 | Phosphorylation | NIQPRTSSASSASLE CCCCCCCCCCCCCCC | 31.40 | 22369663 | |
| 381 | Phosphorylation | QPRTSSASSASLEGT CCCCCCCCCCCCCCC | 28.52 | 22369663 | |
| 382 | Phosphorylation | PRTSSASSASLEGTP CCCCCCCCCCCCCCC | 22.92 | 22369663 | |
| 384 | Phosphorylation | TSSASSASLEGTPKL CCCCCCCCCCCCCCC | 28.97 | 22369663 | |
| 388 | Phosphorylation | SSASLEGTPKLNRTN CCCCCCCCCCCCCCC | 14.10 | 22369663 | |
| 394 | Phosphorylation | GTPKLNRTNSQPLSR CCCCCCCCCCCCCCH | 37.84 | 22369663 | |
| 396 | Phosphorylation | PKLNRTNSQPLSRQA CCCCCCCCCCCCHHH | 32.34 | 22369663 | |
| 400 | Phosphorylation | RTNSQPLSRQAFKNS CCCCCCCCHHHHHCC | 29.09 | 22369663 | |
| 412 | Phosphorylation | KNSKKANSSLSQEID HCCHHHCCCCCCCCC | 37.20 | 19823750 | |
| 413 | Phosphorylation | NSKKANSSLSQEIDL CCHHHCCCCCCCCCH | 31.67 | 19823750 | |
| 415 | Phosphorylation | KKANSSLSQEIDLSQ HHHCCCCCCCCCHHH | 27.93 | 19823750 | |
| 421 | Phosphorylation | LSQEIDLSQLSTTSK CCCCCCHHHCCCHHH | 25.90 | 19823750 | |
| 424 | Phosphorylation | EIDLSQLSTTSKIKM CCCHHHCCCHHHHHH | 23.23 | 19823750 | |
| 425 | Phosphorylation | IDLSQLSTTSKIKML CCHHHCCCHHHHHHH | 43.62 | 19823750 | |
| 426 | Phosphorylation | DLSQLSTTSKIKMLK CHHHCCCHHHHHHHH | 25.33 | 19823750 | |
| 427 | Phosphorylation | LSQLSTTSKIKMLKA HHHCCCHHHHHHHHC | 32.26 | 19823750 | |
| 570 | Phosphorylation | NNENRNESTLTSNNT CCCCCCCCCCCCCCC | 32.06 | 28889911 | |
| 574 | Phosphorylation | RNESTLTSNNTRSSV CCCCCCCCCCCCCCC | 31.06 | 27017623 | |
| 577 | Phosphorylation | STLTSNNTRSSVYDS CCCCCCCCCCCCCCC | 35.86 | 27017623 | |
| 579 | Phosphorylation | LTSNNTRSSVYDSNS CCCCCCCCCCCCCCC | 23.32 | 22369663 | |
| 580 | Phosphorylation | TSNNTRSSVYDSNSF CCCCCCCCCCCCCCC | 22.77 | 22369663 | |
| 582 | Phosphorylation | NNTRSSVYDSNSFNN CCCCCCCCCCCCCCC | 18.66 | 22369663 | |
| 584 | Phosphorylation | TRSSVYDSNSFNNGA CCCCCCCCCCCCCCC | 19.38 | 22369663 | |
| 586 | Phosphorylation | SSVYDSNSFNNGASR CCCCCCCCCCCCCCC | 33.05 | 22369663 | |
| 592 | Phosphorylation | NSFNNGASRNEGLSS CCCCCCCCCCCCCCC | 36.72 | 22369663 | |
| 598 | Phosphorylation | ASRNEGLSSTSRSDS CCCCCCCCCCCCCCC | 42.29 | 22369663 | |
| 599 | Phosphorylation | SRNEGLSSTSRSDSA CCCCCCCCCCCCCCC | 35.13 | 22369663 | |
| 600 | Phosphorylation | RNEGLSSTSRSDSAS CCCCCCCCCCCCCCC | 25.45 | 22369663 | |
| 601 | Phosphorylation | NEGLSSTSRSDSAST CCCCCCCCCCCCCCC | 31.56 | 22369663 | |
| 603 | Phosphorylation | GLSSTSRSDSASTAH CCCCCCCCCCCCCCE | 35.37 | 22369663 | |
| 605 | Phosphorylation | SSTSRSDSASTAHVR CCCCCCCCCCCCEEE | 25.93 | 22369663 | |
| 607 | Phosphorylation | TSRSDSASTAHVRTE CCCCCCCCCCEEEEC | 30.03 | 22369663 | |
| 608 | Phosphorylation | SRSDSASTAHVRTEV CCCCCCCCCEEEECC | 22.09 | 22369663 | |
| 617 | Ubiquitination | HVRTEVNKEEDLGDM EEEECCCCCCCCCCC | 68.60 | 24961812 | |
| 625 | Phosphorylation | EEDLGDMSMVKVRNR CCCCCCCCCEEEECC | 25.76 | 21551504 | |
| 661 | Phosphorylation | PDDSQDRSPELNFGS CCCCCCCCCCCCCCC | 30.89 | 30377154 | |
| 668 | Phosphorylation | SPELNFGSNLDEVLI CCCCCCCCCHHHHHH | 30.04 | 30377154 | |
| 708 | Phosphorylation | MLAQLDKSPQQLSES HHHHHCCCHHHHCHH | 27.84 | 29734811 | |
| 713 | Phosphorylation | DKSPQQLSESTKQIR CCCHHHHCHHHHHHH | 25.76 | 30377154 | |
| 715 | Phosphorylation | SPQQLSESTKQIRAQ CHHHHCHHHHHHHHH | 37.21 | 30377154 | |
| 835 | Phosphorylation | KRMKILITSANTGLV HHCEEEEEECCCCHH | 20.52 | 28132839 | |
| 836 | Phosphorylation | RMKILITSANTGLVE HCEEEEEECCCCHHH | 16.72 | 28132839 | |
| 839 | Phosphorylation | ILITSANTGLVETIT EEEEECCCCHHHHHH | 31.45 | 28132839 | |
| 844 | Phosphorylation | ANTGLVETITNAMSV CCCCHHHHHHHHCCH | 26.14 | 28132839 | |
| 846 | Phosphorylation | TGLVETITNAMSVHS CCHHHHHHHHCCHHH | 25.09 | 28132839 | |
| 853 | Phosphorylation | TNAMSVHSIKKALTK HHHCCHHHHHHHHHH | 33.67 | 28132839 | |
| 892 | Acetylation | FGNPNGFKYRRAQDN HCCCCCCCCHHHHHC | 38.97 | 24489116 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PIK1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PIK1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PIK1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-231; SER-232;THR-233; SER-236; SER-282; SER-378; SER-379; SER-382; SER-384;SER-396; SER-586; SER-592 AND SER-605, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-605 AND THR-608,AND MASS SPECTROMETRY. | |
| "Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry."; Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.; Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; THR-394 AND SER-396,AND MASS SPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-236, AND MASSSPECTROMETRY. | |
| "Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway."; Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.; Mol. Cell. Proteomics 4:310-327(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-233 AND SER-236, ANDMASS SPECTROMETRY. | |
