VATF_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATF_YEAST
• UniProt AC: P39111
• Protein Name: V-type proton ATPase subunit F
• Gene Name: VMA7
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 118
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MAEKRTLIAVIADEDTTTGLLLAGIGQITPETQEKNFFVYQEGKTTKEEITDKFNHFTEERDDIAILLINQHIAENIRARVDSFTNAFPAILEIPSKDHPYDPEKDSVLKRVRKLFGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Ubiquitination	ITPETQEKNFFVYQE CCCCCCCCCEEEEEC	49.60	17644757
44	Ubiquitination	FFVYQEGKTTKEEIT EEEEECCCCCHHHHH	52.87	24961812
44	Acetylation	FFVYQEGKTTKEEIT EEEEECCCCCHHHHH	52.87	24489116
47	2-Hydroxyisobutyrylation	YQEGKTTKEEITDKF EECCCCCHHHHHHHC	59.59	-
53	Ubiquitination	TKEEITDKFNHFTEE CHHHHHHHCCCCCCC	39.14	22106047
83	Phosphorylation	NIRARVDSFTNAFPA HHHHHHHHHCCCCCH	30.98	22369663
85	Phosphorylation	RARVDSFTNAFPAIL HHHHHHHCCCCCHHH	29.59	22369663
97	Ubiquitination	AILEIPSKDHPYDPE HHHCCCCCCCCCCHH	55.49	17644757
105	Ubiquitination	DHPYDPEKDSVLKRV CCCCCHHHHHHHHHH	61.77	22817900
105	Acetylation	DHPYDPEKDSVLKRV CCCCCHHHHHHHHHH	61.77	24489116
110	Ubiquitination	PEKDSVLKRVRKLFG HHHHHHHHHHHHHHC	46.84	22817900
114	Ubiquitination	SVLKRVRKLFGE--- HHHHHHHHHHCC---	45.36	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATF_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATF_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATF_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATA_YEAST	VMA1	physical	11805826
VATG_YEAST	VMA10	physical	11805826
VATH_YEAST	VMA13	physical	11805826
VATE_YEAST	VMA4	physical	11805826
VA0D_YEAST	VMA6	physical	11805826
VATD_YEAST	VMA8	physical	11805826
VPH1_YEAST	VPH1	physical	11805826
VATD_YEAST	VMA8	physical	9334266
VATG_YEAST	VMA10	physical	16554755
VATH_YEAST	VMA13	physical	16554755
VATG_YEAST	VMA10	physical	16429126
VATB_YEAST	VMA2	physical	16429126
VA0D_YEAST	VMA6	physical	16429126
VPH1_YEAST	VPH1	physical	16429126
VATA_YEAST	VMA1	physical	16429126
VATH_YEAST	VMA13	physical	16429126
VATE_YEAST	VMA4	physical	16429126
VATD_YEAST	VMA8	physical	16429126
VMA22_YEAST	VMA22	physical	11283351
ACBP_YEAST	ACB1	physical	18467557
VPH1_YEAST	VPH1	physical	18467557
VATC_YEAST	VMA5	physical	18467557
SNA3_YEAST	SNA3	physical	18467557
VOA1_YEAST	VOA1	physical	18467557
VMA21_YEAST	VMA21	physical	18467557
MEH1_YEAST	MEH1	physical	18467557
VATH_YEAST	VMA13	physical	18467557
VA0D_YEAST	VMA6	physical	18467557
VATB_YEAST	VMA2	physical	22940862
VATE_YEAST	VMA4	physical	22940862
ERD2_YEAST	ERD2	genetic	27708008
CALM_YEAST	CMD1	genetic	27708008
COPA_YEAST	COP1	genetic	27708008
PANK_YEAST	CAB1	genetic	27708008
COPD_YEAST	RET2	genetic	27708008
CP51_YEAST	ERG11	genetic	27708008
FDFT_YEAST	ERG9	genetic	27708008
ERO1_YEAST	ERO1	genetic	27708008
TAP42_YEAST	TAP42	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.