SNA3_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNA3_YEAST
• UniProt AC: P14359
• Protein Name: Protein SNA3
• Gene Name: SNA3
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 133
• Subcellular Localization: Membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Vacuole lumen. Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Sorted via late endosomes to the vacuolar lumen in a ubiquitin-independent manner.
• Protein Sequence: MDRDHINDHDHRMSYSINKDDLLLMVLAVFIPPVAVWKRKGMFNRDTLLNLLLFLLLFFPAIIHACYVVYETSSERSYDLSRRHATAPAVDRDLEAHPAEESQAQPPAYDEDDEAGADVPLMDNKQQLSSGRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	DLSRRHATAPAVDRD CCHHHCCCCCHHCCC	27.35	17563356
125	Ubiquitination	DVPLMDNKQQLSSGR CCCCCCCCHHHHCCC	34.85	23749301

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RSP5	P39940	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNA3_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNA3_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RSP5_YEAST	RSP5	physical	17182850
RSP5_YEAST	RSP5	physical	17645729
PDR12_YEAST	PDR12	physical	18467557
UBX2_YEAST	UBX2	physical	18467557
LCB1_YEAST	LCB1	physical	18467557
MEH1_YEAST	MEH1	physical	18467557
ENG2_YEAST	ACF2	physical	18467557
VATH_YEAST	VMA13	physical	18467557
KES1_YEAST	KES1	physical	18467557
LOA1_YEAST	LOA1	physical	18467557
YIM1_YEAST	YIM1	physical	18467557
TGL1_YEAST	TGL1	physical	18467557
MGLL_YEAST	YJU3	physical	18467557
COPG_YEAST	SEC21	physical	18467557
ERG27_YEAST	ERG27	physical	18467557
SNA3_YEAST	SNA3	physical	18467557
VPS35_YEAST	VPS35	physical	18467557
YCY0_YEAST	YCR090C	genetic	20093466
WDR59_YEAST	MTC5	genetic	20093466
EAF1_YEAST	EAF1	genetic	20093466
YFF2_YEAST	YFL052W	genetic	20093466
VAM7_YEAST	VAM7	genetic	20093466
RME1_YEAST	RME1	genetic	20093466
THIK_YEAST	POT1	genetic	20093466
ATG32_YEAST	ATG32	genetic	20093466
OCA2_YEAST	OCA2	genetic	20093466
YP089_YEAST	YPR089W	genetic	20093466
PDR12_YEAST	PDR12	physical	22615397
HSP71_YEAST	SSA1	physical	22940862
UBI4P_YEAST	UBI4	physical	23936628
SNA4_YEAST	SNA4	genetic	26303201
RSP5_YEAST	RSP5	physical	25942624
GPR1_YEAST	GPR1	genetic	27708008
UBC13_YEAST	UBC13	genetic	27708008
YFF2_YEAST	YFL052W	genetic	27708008
EFM4_YEAST	EFM4	genetic	27708008
ATG32_YEAST	ATG32	genetic	27708008
PUB1_YEAST	PUB1	genetic	27708008
RAS2_YEAST	RAS2	genetic	27708008
THI22_YEAST	THI22	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-86, AND MASSSPECTROMETRY.
PubMed: 17563356

Ubiquitylation

"A subset of membrane-associated proteins is ubiquitinated in responseto mutations in the endoplasmic reticulum degradation machinery.";
Hitchcock A.L., Auld K., Gygi S.P., Silver P.A.;
Proc. Natl. Acad. Sci. U.S.A. 100:12735-12740(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-125, AND MASSSPECTROMETRY.
PubMed: 14557538