| UniProt ID | VPS35_YEAST | |
|---|---|---|
| UniProt AC | P34110 | |
| Protein Name | Vacuolar protein sorting-associated protein 35 | |
| Gene Name | VPS35 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 944 | |
| Subcellular Localization |
Membrane Peripheral membrane protein. |
|
| Protein Description | Plays a role in vesicular protein sorting. Required for the endosome-to-Golgi retrieval of the vacuolar protein sorting receptor VPS10. Vacuolar carboxypeptidase Y (CPY) sorting is completely dependent on the presence of functional VPS35. The latter may play a role in the function, modification or packaging of a CPY-specific receptor complex. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in cargo selection.. | |
| Protein Sequence | MAYADSPENAIAVIKQRTALMNRCLSQHKLMESLQHTSIMLTELRNPNLSPKKYYELYVIIFDSLTNLSTYLIENHPQNHHLADLYELVQYTGNVVPRLYLMITVGTSYLTFNEAPKKEILKDMIEMCRGVQNPIRGLFLRYYLSQRTKELLPEDDPSFNSQFIMNNFIEMNKLWVRLQHQGPLRERETRTRERKELQILVGSQLVRLSQIIDDNFQMYKQDILPTILEQVIQCRDLVSQEYLLDVICQVFADEFHLKTLDTLLQTTLHLNPDVSINKIVLTLVDRLNDYVTRQLEDDPNATSTNAYLDMDVFGTFWDYLTVLNHERPDLSLQQFIPLVESVIVLSLKWYPNNFDNLNKLFELVLQKTKDYGQKNISLESEHLFLVLLSFQNSKLQLTSSTTAPPNSPVTSKKHFIFQLISQCQAYKNILALQSISLQKKVVNEIIDILMDREVEEMADNDSESKLHPPGHSAYLVIEDKLQVQRLLSICEPLIISRSGPPANVASSDTNVDEVFFNRHDEEESWILDPIQEKLAHLIHWIMNTTSRKQTMKNKIQFSLEAQLEILLLIKSSFIKGGINVKYTFPAIITNFWKLMRKCRMIQEYLLKKRPDNKTLLSHYSNLLKQMFKFVSRCINDIFNSCNNSCTDLILKLNLQCAILADQLQLNEISYDFFSQAFTIFEESLSDSKTQLQALIYIAQSLQKTRSLYKEAYYDSLIVRCTLHGSKLLKKQDQCRAVYLCSHLWWATEISNIGEEEGITDNFYRDGKRVLECLQRSLRVADSIMDNEQSCELMVEILNRCLYYFIHGDESETHISIKYINGLIELIKTNLKSLKLEDNSASMITNSISDLHITGENNVKASSNADDGSVITDKESNVAIGSDGTYIQLNTLNGSSTLIRGVVATASGSKLLHQLKYIPIHHFRRTCEYIESQREVDDRFKVIYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MAYADSPENA -----CCCCCCHHHH | 15.05 | 21126336 | |
| 399 | Phosphorylation | NSKLQLTSSTTAPPN CCEEEEEECCCCCCC | 33.99 | 28889911 | |
| 402 | Phosphorylation | LQLTSSTTAPPNSPV EEEEECCCCCCCCCC | 38.83 | 28889911 | |
| 407 | Phosphorylation | STTAPPNSPVTSKKH CCCCCCCCCCCCCHH | 26.90 | 28889911 | |
| 410 | Phosphorylation | APPNSPVTSKKHFIF CCCCCCCCCCHHHHH | 37.91 | 28889911 | |
| 411 | Phosphorylation | PPNSPVTSKKHFIFQ CCCCCCCCCHHHHHH | 39.68 | 28889911 | |
| 462 | Phosphorylation | EEMADNDSESKLHPP HHHCCCCCCCCCCCC | 50.45 | 29734811 | |
| 464 | Phosphorylation | MADNDSESKLHPPGH HCCCCCCCCCCCCCC | 44.46 | 28889911 | |
| 498 | Phosphorylation | EPLIISRSGPPANVA CCEEECCCCCCCCCC | 49.19 | 29688323 | |
| 506 | Phosphorylation | GPPANVASSDTNVDE CCCCCCCCCCCCCCC | 25.19 | 29688323 | |
| 507 | Phosphorylation | PPANVASSDTNVDEV CCCCCCCCCCCCCCC | 38.42 | 28889911 | |
| 509 | Phosphorylation | ANVASSDTNVDEVFF CCCCCCCCCCCCCCC | 38.80 | 28889911 | |
| 839 | Phosphorylation | SLKLEDNSASMITNS HCCCCCCCCHHHHHC | 33.76 | 22369663 | |
| 841 | Phosphorylation | KLEDNSASMITNSIS CCCCCCCHHHHHCHH | 15.56 | 22369663 | |
| 844 | Phosphorylation | DNSASMITNSISDLH CCCCHHHHHCHHHEE | 17.80 | 22369663 | |
| 846 | Phosphorylation | SASMITNSISDLHIT CCHHHHHCHHHEEEE | 18.15 | 22369663 | |
| 848 | Phosphorylation | SMITNSISDLHITGE HHHHHCHHHEEEECC | 33.66 | 22369663 | |
| 868 | Phosphorylation | SSNADDGSVITDKES CCCCCCCCCCCCCCC | 19.83 | 25521595 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS35_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS35_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS35_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507; THR-844 ANDSER-868, AND MASS SPECTROMETRY. | |
