| UniProt ID | EI2BB_YEAST | |
|---|---|---|
| UniProt AC | P32502 | |
| Protein Name | Translation initiation factor eIF-2B subunit beta | |
| Gene Name | GCD7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 381 | |
| Subcellular Localization | ||
| Protein Description | Acts as a regulatory component of the translation initiation factor 2B (eIF2-B or GCD complex), which catalyzes the exchange of eukaryotic initiation factor 2 (eIF-2)-bound GDP for GTP and is regulated by phosphorylated eIF-2. It activates the synthesis of GCN4 in yeast under amino acid starvation conditions by suppressing the inhibitory effects of multiple AUG codons present in the leader of GCN4 mRNA. It may promote either repression or activation of GCN4 expression depending on amino acid availability. GCD6 and GCD7 repress GCN4 expression at the translational level by ensuring that ribosomes which have translated UORF1 will reinitiate at UORF2, -3, or -4 and thus fail to reach the GCN4 start site.. | |
| Protein Sequence | MSSQAFTSVHPNAATSDVNVTIDTFVAKLKRRQVQGSYAIALETLQLLMRFISAARWNHVNDLIEQIRDLGNSLEKAHPTAFSCGNVIRRILAVLRDEVEEDTMSTTVTSTSVAEPLISSMFNLLQKPEQPHQNRKNSSGSSSMKTKTDYRQVAIQGIKDLIDEIKNIDEGIQQIAIDLIHDHEILLTPTPDSKTVLKFLITARERSNRTFTVLVTEGFPNNTKNAHEFAKKLAQHNIETLVVPDSAVFALMSRVGKVIIGTKAVFVNGGTISSNSGVSSVCECAREFRTPVFAVAGLYKLSPLYPFDVEKFVEFGGSQRILPRMDPRKRLDTVNQITDYVPPENIDIYITNVGGFNPSFIYRIAWDNYKQIDVHLDKNKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 105 | Phosphorylation | EVEEDTMSTTVTSTS HCCCCCCCCEECCCC | 24.02 | 27017623 | |
| 111 | Phosphorylation | MSTTVTSTSVAEPLI CCCEECCCCHHHHHH | 20.18 | 27017623 | |
| 120 | Phosphorylation | VAEPLISSMFNLLQK HHHHHHHHHHHHHHC | 22.02 | 27017623 | |
| 138 | Phosphorylation | PHQNRKNSSGSSSMK CCCCCCCCCCCCCCC | 38.83 | 28889911 | |
| 139 | Phosphorylation | HQNRKNSSGSSSMKT CCCCCCCCCCCCCCC | 52.68 | 27017623 | |
| 141 | Phosphorylation | NRKNSSGSSSMKTKT CCCCCCCCCCCCCCC | 22.61 | 27017623 | |
| 142 | Phosphorylation | RKNSSGSSSMKTKTD CCCCCCCCCCCCCCC | 37.67 | 27017623 | |
| 302 | Phosphorylation | VAGLYKLSPLYPFDV EEEEEECCCCCCCCH | 14.54 | 28889911 | |
| 311 | Ubiquitination | LYPFDVEKFVEFGGS CCCCCHHHHHHCCCC | 55.34 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of EI2BB_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of EI2BB_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of EI2BB_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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