DUT_YEAST - dbPTM
DUT_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DUT_YEAST
UniProt AC P33317
Protein Name Deoxyuridine 5'-triphosphate nucleotidohydrolase
Gene Name DUT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 147
Subcellular Localization
Protein Description This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA..
Protein Sequence MTATSDKVLKIQLRSASATVPTKGSATAAGYDIYASQDITIPAMGQGMVSTDISFTVPVGTYGRIAPRSGLAVKNGIQTGAGVVDRDYTGEVKVVLFNHSQRDFAIKKGDRVAQLILEKIVDDAQIVVVDSLEESARGAGGFGSTGN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10AcetylationATSDKVLKIQLRSAS
CCCCCEEEEEEEECC		31.2424489116
17PhosphorylationKIQLRSASATVPTKG
EEEEEECCCCCCCCC		26.2221082442
74UbiquitinationPRSGLAVKNGIQTGA
CCCCCEEECCCCCCC		43.8024961812
88PhosphorylationAGVVDRDYTGEVKVV
CCEECCCCCCCEEEE		19.9620377248
89PhosphorylationGVVDRDYTGEVKVVL
CEECCCCCCCEEEEE		31.0222369663
144PhosphorylationRGAGGFGSTGN----
CCCCCCCCCCC----		30.7728889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DUT_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DUT_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DUT_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UNG_YEASTUNG1genetic
8223452
APN1_YEASTAPN1genetic
16617146
APN2_YEASTAPN2genetic
16617146
RAD14_YEASTRAD14genetic
16617146
UNG_YEASTUNG1genetic
16617146
DPOZ_YEASTREV3genetic
16617146
DUT_YEASTDUT1physical
18719252
PP11_YEASTSIT4genetic
19269370
KCS1_YEASTKCS1genetic
19269370
TPS2_YEASTTPS2genetic
19269370
SKI8_YEASTSKI8genetic
19269370
SLX9_YEASTSLX9genetic
19269370
ELP2_YEASTELP2genetic
19269370
STE20_YEASTSTE20genetic
19269370
OPI1_YEASTOPI1genetic
19269370
LRP1_YEASTLRP1genetic
19269370
LSM1_YEASTLSM1genetic
19269370
SA190_YEASTSAP190genetic
19269370
RIC1_YEASTRIC1genetic
19269370
FIG4_YEASTFIG4genetic
19269370
BRE5_YEASTBRE5genetic
19269370
ELP3_YEASTELP3genetic
19269370
PDC1_YEASTPDC1genetic
21623372
SOL3_YEASTSOL3genetic
21623372
THDH_YEASTILV1genetic
21623372
HXKB_YEASTHXK2genetic
21623372
COQ4_YEASTCOQ4genetic
21623372
SDHX_YEASTYJL045Wgenetic
21623372
FOLE_YEASTMET7genetic
21623372
AROC_YEASTARO2genetic
21623372
MET22_YEASTMET22genetic
21623372
EOS1_YEASTEOS1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
PSB6_YEASTPRE7genetic
27708008
CND2_YEASTBRN1genetic
27708008
PRP6_YEASTPRP6genetic
27708008
KRR1_YEASTKRR1genetic
27708008
PRP11_YEASTPRP11genetic
27708008
NOP14_YEASTNOP14genetic
27708008
TIM22_YEASTTIM22genetic
27708008
LCB2_YEASTLCB2genetic
27708008
TAF12_YEASTTAF12genetic
27708008
MOB2_YEASTMOB2genetic
27708008
GPI10_YEASTGPI10genetic
27708008
TEL2_YEASTTEL2genetic
27708008
SDA1_YEASTSDA1genetic
27708008
ORC6_YEASTORC6genetic
27708008
SMC3_YEASTSMC3genetic
27708008
DPB11_YEASTDPB11genetic
27708008
DPOD2_YEASTPOL31genetic
27708008
FNTA_YEASTRAM2genetic
27708008
CWC16_YEASTYJU2genetic
27708008
PRP19_YEASTPRP19genetic
27708008
AFG2_YEASTAFG2genetic
27708008
ORC1_YEASTORC1genetic
27708008
CBF3B_YEASTCEP3genetic
27708008
NOP2_YEASTNOP2genetic
27708008
DBP6_YEASTDBP6genetic
27708008
RIB2_YEASTRIB2genetic
27708008
NUF2_YEASTNUF2genetic
27708008
RPB2_YEASTRPB2genetic
27708008
ESA1_YEASTESA1genetic
27708008
CLP1_YEASTCLP1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
TBF1_YEASTTBF1genetic
27708008
HRR25_YEASTHRR25genetic
27708008
DIB1_YEASTDIB1genetic
27708008
SHE1_YEASTSHE1genetic
27708008
ATG8_YEASTATG8genetic
27708008
VAM6_YEASTVAM6genetic
27708008
CEM1_YEASTCEM1genetic
27708008
MUP1_YEASTMUP1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
HTD2_YEASTHTD2genetic
27708008
ENV10_YEASTENV10genetic
27708008
ALAM_YEASTALT1genetic
27708008
YPT7_YEASTYPT7genetic
27708008
LIPA_YEASTLIP5genetic
27708008
FABD_YEASTMCT1genetic
27708008
TGS1_YEASTTGS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DUT_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-89, AND MASSSPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-89, AND MASSSPECTROMETRY.

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