FIG4_YEAST - dbPTM
FIG4_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID FIG4_YEAST
UniProt AC P42837
Protein Name Polyphosphoinositide phosphatase
Gene Name FIG4
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 879
Subcellular Localization Vacuole membrane
Peripheral membrane protein . Localized to the limiting membrane of the vacuole. Localization requires VAC14 and FAB1.
Protein Description The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Major enzyme required for hyperosmotic shock-induced turnover of PtdIns(3,5)P2 and requires VAC14 for this function. In vivo, mediates turnover of PtdIns(3,5)P2 at the vacuole membrane necessary for vacuolar size control. In vitro, catalyzes the removal of phosphate from the fifth hydroxyl of the myo-inositol ring of phosphatidylinositol 3,5-bisphosphate..
Protein Sequence MNNDAMEHTLGGGILTTSGSKQRKTSKFVMGKYTLYETKDRMYIVGSNKRETMFRILEIDLTVPRGELTVLEDNVFFTRNEIMNVLASLEEATEDGLHKKITGYGLLGFIKFTCWYYLIMVTKYSQVAVIGGHGIYHIDGIDIIPITNNYKKPEKSSDEARLLNIFKDLDLTKTFYFSYTYDITNTLQTNILREKLKAVDRCDITIPCGITDYNEMFVWNNNLLSPIFACIDTVFDWFQCIIHGFIDQVNVSVLGKSIYITLIARRSHHFAGARFLKRGVNNKGHVANEVETEQIVTDMILTPFHQPGNGFFDSDRYTSFVQHRGSIPLYWTQDASNLTTKPPIRINVVDPFFSPAALHFDNLFQRYGGGTIQILNLIKTKEKTPRETKLLWEFEQCIDYLNEFLPTLKKLDYTSWDMSRASKQDGQGVIEFLEKYAVNTVTTTGIFHNGPDFASTKIQEGICRSNCIDCLDRTNAAQFVIGKRALGCQLKSLGIIDNSYLEYDSDIVNILTELFHDLGDTIALQYGGSHLVNTMETYRKINQWSSHSRDMIESIKRFYSNSFVDAQRQDAINLFLGHYSWREGFPSLWEMNTDFYLHNAYSLNMPKRSYIHWWNDYNIKSVKELINEELIATGNDVTREKIIKNVRGYPGAFDNYWNEYYLPRSVTWIRDLFAYNMNSTRRYHNALSKQDKAMSPFTSRKQSWLNNKLKMITSSKSLEKAEGRVVETTDLDRDTSPKQELELYEHYLHIISDRSQKLEEKMNSFSYSKYPIFISHESSEIPPMRKVIGEPLVDIAEDFTDVYDDDDDGDDENDEMTTEALLIAPDHVSVDEKFYEKVLNVDDYKPALDDYSAVIHIKPDNLQLYRDLCFSKDIQLDFQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationNNDAMEHTLGGGILT
CCCHHCCCCCCCEEC		17.5025882841
17PhosphorylationLGGGILTTSGSKQRK
CCCCEECCCCCCCCC		27.8725882841
18PhosphorylationGGGILTTSGSKQRKT
CCCEECCCCCCCCCC		35.5228889911
554PhosphorylationHSRDMIESIKRFYSN
CCHHHHHHHHHHHHC		23.6127017623
695PhosphorylationSKQDKAMSPFTSRKQ
CCCCCCCCCCCHHHH		23.0127214570
728PhosphorylationAEGRVVETTDLDRDT
HCCCEEEECCCCCCC		17.6330377154
768PhosphorylationKMNSFSYSKYPIFIS
HHHCCCCCCCCEEEE		25.2327017623
775PhosphorylationSKYPIFISHESSEIP
CCCCEEEEECCCCCC		15.5127017623
779PhosphorylationIFISHESSEIPPMRK
EEEEECCCCCCCHHH		36.2427017623
829PhosphorylationLIAPDHVSVDEKFYE
EECCCCCCCCHHHHH		22.0417572665
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of FIG4_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of FIG4_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of FIG4_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FIG2_YEASTFIG2genetic
9456310
OAF1_YEASTOAF1physical
16554755
VAC14_YEASTVAC14physical
16554755
KRE5_YEASTKRE5physical
16554755
ADK_YEASTADO1genetic
19269370
PSR1_YEASTPSR1genetic
19269370
VAC14_YEASTVAC14physical
19037259
FAB1_YEASTFAB1physical
19037259
FAB1_YEASTFAB1genetic
21127252
KCS1_YEASTKCS1genetic
21127252
RTG3_YEASTRTG3genetic
21127252
VPS53_YEASTVPS53genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
ERG3_YEASTERG3genetic
27708008
INO4_YEASTINO4genetic
27708008
RU2A_YEASTLEA1genetic
27708008
STX8_YEASTSYN8genetic
27708008
RL19A_YEASTRPL19Bgenetic
27708008
RL19B_YEASTRPL19Bgenetic
27708008
ETR1_YEASTETR1genetic
27708008
RL4A_YEASTRPL4Agenetic
27708008
BUD31_YEASTBUD31genetic
27708008
RMD1_YEASTRMD1genetic
27708008
SLX5_YEASTSLX5genetic
27708008
BAP3_YEASTBAP3genetic
27708008
YD179_YEASTYDR179W-Agenetic
27708008
MNN10_YEASTMNN10genetic
27708008
IES5_YEASTIES5genetic
27708008
ATG18_YEASTATG18genetic
27708008
CUL3_YEASTCUL3genetic
27708008
TNA1_YEASTTNA1genetic
27708008
MED20_YEASTSRB2genetic
27708008
HTD2_YEASTHTD2genetic
27708008
ATG32_YEASTATG32genetic
27708008
YJE9_YEASTYJL049Wgenetic
27708008
BCK1_YEASTBCK1genetic
27708008
MMM1_YEASTMMM1genetic
27708008
MMS22_YEASTMMS22genetic
27708008
FKS1_YEASTFKS1genetic
27708008
VPS38_YEASTVPS38genetic
27708008
RL31B_YEASTRPL31Bgenetic
27708008
DIA2_YEASTDIA2genetic
27708008
FABD_YEASTMCT1genetic
27708008
PMT3_YEASTPMT3genetic
27708008
CHL1_YEASTCHL1genetic
27708008
BECN1_YEASTVPS30genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
YAR1_YEASTYAR1genetic
27708008
MED1_YEASTMED1genetic
27708008
SLT2_YEASTSLT2genetic
29674565
ICE2_YEASTICE2genetic
29674565
LST8_YEASTLST8genetic
29674565
COPB_YEASTSEC26genetic
29674565
ATC1_YEASTPMR1genetic
29674565
VPS29_YEASTVPS29genetic
29674565
BET3_YEASTBET3genetic
29674565
RIC1_YEASTRIC1genetic
29674565
VPS38_YEASTVPS38genetic
29674565
YPT7_YEASTYPT7genetic
29674565
SCS7_YEASTSCS7genetic
29674565
GYP1_YEASTGYP1genetic
29674565
PSB6_YEASTPRE7genetic
29674565
AVT5_YEASTAVT5genetic
29674565
CKS1_YEASTCKS1genetic
29674565
BPH1_YEASTBPH1genetic
29674565
PAT1_YEASTPAT1genetic
29674565
RPN6_YEASTRPN6genetic
29674565
UAP1_YEASTQRI1genetic
29674565
CYK3_YEASTCYK3genetic
29674565
TCPA_YEASTTCP1genetic
29674565
TFB1_YEASTTFB1genetic
29674565
MSN5_YEASTMSN5genetic
29674565
GRH1_YEASTGRH1genetic
29674565
DBF2_YEASTDBF2genetic
29674565
PSA3_YEASTPRE9genetic
29674565
YHH7_YEASTYSC83genetic
29674565
RPN1_YEASTRPN1genetic
29674565
YHS2_YEASTCIA2genetic
29674565
BCK1_YEASTBCK1genetic
29674565
TCPE_YEASTCCT5genetic
29674565
FRMSR_YEASTYKL069Wgenetic
29674565
PRS7_YEASTRPT1genetic
29674565
DOA1_YEASTDOA1genetic
29674565
SA190_YEASTSAP190genetic
29674565
PFD6_YEASTYKE2genetic
29674565
BUD6_YEASTBUD6genetic
29674565
IMB1_YEASTKAP95genetic
29674565
ORC1_YEASTORC1genetic
29674565
JNM1_YEASTJNM1genetic
29674565
MAS5_YEASTYDJ1genetic
29674565
RS7B_YEASTRPS7Bgenetic
29674565
PSA4_YEASTPRE6genetic
29674565
MYO2_YEASTMYO2genetic
29674565
BECN1_YEASTVPS30genetic
29674565
CTI6_YEASTCTI6genetic
29674565
RPN7_YEASTRPN7genetic
29674565
SEC23_YEASTSEC23genetic
29674565
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of FIG4_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-829, AND MASSSPECTROMETRY.

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