VPS53_YEAST - dbPTM
VPS53_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID VPS53_YEAST
UniProt AC P47061
Protein Name Vacuolar protein sorting-associated protein 53
Gene Name VPS53
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 822
Subcellular Localization Golgi apparatus, trans-Golgi network membrane
Peripheral membrane protein. Endosome membrane
Peripheral membrane protein.
Protein Description Involved in retrograde transport from early and late endosomes to late Golgi by linking the vesicle through the t-SNARE TGL1 to the Golgi, leading to the membrane fusion between late Golgi and endosomal vesicles..
Protein Sequence MLEGTVDYDPLEDITNILFSKESLNNIDELISITRSYKKQLQEDILKEENELKEHPKNSAEIEASLRKVFQDFKETQDVSASTELTISNLTEGISYLDIAKKNLTHSLTLFQNLKILTDSYIQCNELLSQGSFKKMVSPYKIMCSLAENTFISYKSLDEINYLLSSISRLKGDTLSKIKQNYNALFSGGNISEHDTALTMELREGACELLDCDTSTRAQMIDWCLDKLLFEMKEIFRVDDEAGSLENLSRRYIYFKKILNNFNSKFADYFLKDWEMAVRLTTTFYHITHKDLQTLLKREFKDKNPSIDLFMTALQSTLDFEKYIDVRFSKKIKEPKLSSCFEPYLTLWVSHQNQMMEKKFLSYMSEPKYPSNETESLVLPSSADLFRTYRSVLTQTLELIDNNANDSILTSLANFFSRWLQTYSQKILLPLLLPDNIEVQDKLEAAKYTVLLINTADYCATTIDQLEDKLSEFSGNREKLANSFTKTKNIYDDLLAKGTSFLLNRVIPLDLNFVWREFINNDWSNAAIEDYSRYMVTLKSVLKMPALTDASIKQQQEQPSTLAFILSQFNRDVYKWNFLDKVIDIITTNFVSNTIRLLQPVPPFSLAGSKRKFETRTVVNIGEQLLLDLELLKEIFHTLPESVSNDSDLRENTSYKRVKRHADNNIDQLLKFIKLLMAPLDSADDYYETYSKLTNNNPDSAVWSFVLALKGIPWDLALWKKLWSAYNLETDDTDEGSRPDSNRDLFIFKWDKVLLGQFENNLARMQDPNWSKFVRQDLKISPPVMKRIVSTPQIQQQKEEQKKQSLSVKDFVSHSRFFNRGT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMLEGTVDYDPLEDIT
CCCCCCCCCCHHHHH		18.3521551504
15PhosphorylationYDPLEDITNILFSKE
CCCHHHHHHHHCCHH		28.6421551504
20PhosphorylationDITNILFSKESLNNI
HHHHHHCCHHHHCCH		31.8721551504
32PhosphorylationNNIDELISITRSYKK
CCHHHHHHHHHHHHH		30.4528889911
65PhosphorylationNSAEIEASLRKVFQD
CHHHHHHHHHHHHHH		18.8627017623
281PhosphorylationWEMAVRLTTTFYHIT
HHHHHHHHHHHHHCC		17.1530377154
282PhosphorylationEMAVRLTTTFYHITH
HHHHHHHHHHHHCCH		21.3530377154
283PhosphorylationMAVRLTTTFYHITHK
HHHHHHHHHHHCCHH		19.5730377154
285PhosphorylationVRLTTTFYHITHKDL
HHHHHHHHHCCHHHH		7.1030377154
288PhosphorylationTTTFYHITHKDLQTL
HHHHHHCCHHHHHHH		15.0130377154
294PhosphorylationITHKDLQTLLKREFK
CCHHHHHHHHHHHHC		41.1630377154
303UbiquitinationLKREFKDKNPSIDLF
HHHHHCCCCCCHHHH		71.9319722269
322UbiquitinationQSTLDFEKYIDVRFS
HHHCCHHHHHCHHCC		47.7219722269
362PhosphorylationMMEKKFLSYMSEPKY
HHHHHHHHHHCCCCC		23.1730377154
483PhosphorylationNREKLANSFTKTKNI
CHHHHHHHHHHCCCH		28.7828889911
485PhosphorylationEKLANSFTKTKNIYD
HHHHHHHHHCCCHHH		37.3128889911
671AcetylationNNIDQLLKFIKLLMA
CCHHHHHHHHHHHHC		54.3524489116
790PhosphorylationPVMKRIVSTPQIQQQ
HHHHHHHCCHHHHHH		31.8122369663
791PhosphorylationVMKRIVSTPQIQQQK
HHHHHHCCHHHHHHH		14.3322369663
813PhosphorylationLSVKDFVSHSRFFNR
CCHHHHHHHHHHHCC		18.7530377154
815PhosphorylationVKDFVSHSRFFNRGT
HHHHHHHHHHHCCCC		24.2317287358
822PhosphorylationSRFFNRGT-------
HHHHCCCC-------		32.0021440633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of VPS53_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of VPS53_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of VPS53_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VPS54_YEASTVPS54physical
11805826
VPS52_YEASTVPS52physical
11805826
VPS52_YEASTVPS52physical
12686613
VPS52_YEASTVPS52physical
10637310
VPS51_YEASTVPS51physical
12446664
VPS54_YEASTVPS54physical
10637310
VPS10_YEASTPEP1physical
10637310
GRP78_YEASTKAR2physical
16429126
VPS52_YEASTVPS52physical
16429126
VPS54_YEASTVPS54physical
16429126
EOS1_YEASTEOS1genetic
20101242
CHO2_YEASTCHO2genetic
20101242
FAT1_YEASTFAT1genetic
19325107
GET2_YEASTGET2genetic
19325107
GLO3_YEASTGLO3genetic
19325107
HLJ1_YEASTHLJ1genetic
19325107
HMDH1_YEASTHMG1genetic
19325107
MGA2_YEASTMGA2genetic
19325107
PLMT_YEASTOPI3genetic
19325107
OST3_YEASTOST3genetic
19325107
SET3_YEASTSET3genetic
19325107
SKY1_YEASTSKY1genetic
19325107
SPT4_YEASTSPT4genetic
19325107
ELO3_YEASTELO3genetic
19325107
VPS1_YEASTVPS1genetic
19325107
YD056_YEASTYDR056Cgenetic
19325107
YHN8_YEASTYHR078Wgenetic
19325107
GET4_YEASTGET4genetic
19325107
ARL1_YEASTARL1genetic
19325107
CALX_YEASTCNE1genetic
19325107
CWH43_YEASTCWH43genetic
19325107
ERP1_YEASTERP1genetic
19325107
ISW1_YEASTISW1genetic
19325107
LEM3_YEASTLEM3genetic
19325107
ORM2_YEASTORM2genetic
19325107
PSD2_YEASTPSD2genetic
19325107
RER1_YEASTRER1genetic
19325107
SC61A_YEASTSEC61genetic
19325107
SEC62_YEASTSEC62genetic
19325107
YPC1_YEASTYPC1genetic
26357016
SEC7_YEASTSEC7genetic
27708008
SGM1_YEASTSGM1genetic
27708008
VPS13_YEASTVPS13genetic
27708008
IMH1_YEASTIMH1genetic
27708008
COG8_YEASTCOG8genetic
27708008
PKR1_YEASTPKR1genetic
27708008
CSK2C_YEASTCKB2genetic
27708008
SNX3_YEASTSNX3genetic
27708008
SLY1_YEASTSLY1genetic
27811238
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of VPS53_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32; SER-790 AND THR-791,AND MASS SPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-790 AND SER-815, ANDMASS SPECTROMETRY.

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