SNX3_YEAST - dbPTM
SNX3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNX3_YEAST
UniProt AC Q08826
Protein Name Sorting nexin-3
Gene Name SNX3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 162
Subcellular Localization Cytoplasm . Golgi apparatus membrane
Peripheral membrane protein
Cytoplasmic side . Prevacuolar compartment membrane
Peripheral membrane protein
Cytoplasmic side . Mainly cytoplasmic. A minor amount associates with membranes.
Protein Description Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3))..
Protein Sequence MPREFKSFGSTEKSLLSKGHGEPSYSEIYAEPENFLEIEVHNPKTHIPNGMDSKGMFTDYEIICRTNLPSFHKRVSKVRRRYSDFEFFRKCLIKEISMLNHPKVMVPHLPGKILLSNRFSNEVIEERRQGLNTWMQSVAGHPLLQSGSKVLVRFIEAEKFVG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
6Acetylation--MPREFKSFGSTEK
--CCCCCCCCCCHHH		39.8725381059
7Phosphorylation-MPREFKSFGSTEKS
-CCCCCCCCCCHHHH		39.9130377154
11PhosphorylationEFKSFGSTEKSLLSK
CCCCCCCHHHHHHHC		48.0530377154
13UbiquitinationKSFGSTEKSLLSKGH
CCCCCHHHHHHHCCC		46.6323749301
13AcetylationKSFGSTEKSLLSKGH
CCCCCHHHHHHHCCC		46.6324489116
18UbiquitinationTEKSLLSKGHGEPSY
HHHHHHHCCCCCCCH		55.7022817900
24PhosphorylationSKGHGEPSYSEIYAE
HCCCCCCCHHHEEEC		36.6730377154
26PhosphorylationGHGEPSYSEIYAEPE
CCCCCCHHHEEECCC		23.1230377154
83PhosphorylationSKVRRRYSDFEFFRK
HHHHHHHCHHHHHHH		33.7317287358
112AcetylationMVPHLPGKILLSNRF
ECCCCCCCEEECCCC		28.3924489116
116PhosphorylationLPGKILLSNRFSNEV
CCCCEEECCCCCHHH		23.6328889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNX3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNX3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNX3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ADH1_YEASTADH1physical
15263065
AKR2_YEASTAKR2physical
15263065
ATG17_YEASTATG17physical
15263065
RBD2_YEASTRBD2physical
15263065
RV167_YEASTRVS167physical
15263065
SEC15_YEASTSEC15physical
15263065
YIF1_YEASTYIF1physical
15263065
YIP1_YEASTYIP1physical
15263065
YIP5_YEASTYIP5physical
15263065
YPT53_YEASTYPT53physical
15263065
YL031_YEASTYLR031Wphysical
15263065
SP382_YEASTSPP382physical
15263065
VPS29_YEASTVPS29genetic
18768754
CDC1_YEASTCDC1genetic
27708008
SED5_YEASTSED5genetic
27708008
SMI1_YEASTSMI1genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
YP022_YEASTYPR022Cgenetic
27708008
TECR_YEASTTSC13genetic
27708008
PRP11_YEASTPRP11genetic
27708008
CDC37_YEASTCDC37genetic
27708008
RSP5_YEASTRSP5genetic
27708008
CDC4_YEASTCDC4genetic
27708008
ACT_YEASTACT1genetic
27708008
RPN12_YEASTRPN12genetic
27708008
SMD1_YEASTSMD1genetic
27708008
SPC97_YEASTSPC97genetic
27708008
ATC7_YEASTNEO1genetic
27708008
EXO70_YEASTEXO70genetic
27708008
RPF2_YEASTRPF2genetic
27708008
SEC22_YEASTSEC22genetic
27708008
VTI1_YEASTVTI1genetic
27708008
IF6_YEASTTIF6genetic
27708008
ATC3_YEASTDRS2genetic
27708008
CHK1_YEASTCHK1genetic
27708008
VAM6_YEASTVAM6genetic
27708008
PSP1_YEASTPSP1genetic
27708008
DBP3_YEASTDBP3genetic
27708008
MMS2_YEASTMMS2genetic
27708008
MED5_YEASTNUT1genetic
27708008
VAM7_YEASTVAM7genetic
27708008
KEL1_YEASTKEL1genetic
27708008
VPS53_YEASTVPS53genetic
27708008
YJ24_YEASTKCH1genetic
27708008
JHD2_YEASTJHD2genetic
27708008
UTH1_YEASTUTH1genetic
27708008
ROM2_YEASTROM2genetic
27708008
RAD10_YEASTRAD10genetic
27708008
SUB1_YEASTSUB1genetic
27708008
SSO2_YEASTSSO2genetic
27708008
TPM1_YEASTTPM1genetic
27708008
LSM7_YEASTLSM7genetic
27708008
BRE5_YEASTBRE5genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
CGS5_YEASTCLB5genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNX3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND MASSSPECTROMETRY.
"Analysis of phosphorylation sites on proteins from Saccharomycescerevisiae by electron transfer dissociation (ETD) massspectrometry.";
Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83, AND MASSSPECTROMETRY.

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