| UniProt ID | ATC7_YEAST | |
|---|---|---|
| UniProt AC | P40527 | |
| Protein Name | Probable phospholipid-transporting ATPase NEO1 | |
| Gene Name | NEO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1151 | |
| Subcellular Localization |
Endosome membrane Multi-pass membrane protein . Golgi apparatus membrane Multi-pass membrane protein . |
|
| Protein Description | This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Potential). Leads to neomycin-resistance when overexpressed. Required for traffic between late Golgi and early endosomes.. | |
| Protein Sequence | MPNPPSFKSHKQNLFNSNNNQHANSVDSFDLHLDDSFDAALDSLQINNNPEPLSKHNTVGDRESFEMRTVDDLDNFSNHSSDSHRKSSNTDTHPLMYDNRLSQDDNFKFTNIASSPPSSSNNIFSKALSYLKVSNTKNWSKFGSPIELSDQHIEREIHPDTTPVYDRNRYVSNELSNAKYNAVTFVPTLLYEQFKFFYNLYFLVVALSQAVPALRIGYLSSYIVPLAFVLTVTMAKEAIDDIQRRRRDRESNNELYHVITRNRSIPSKDLKVGDLIKVHKGDRIPADLVLLQSSEPSGESFIKTDQLDGETDWKLRVACPLTQNLSENDLINRISITASAPEKSIHKFLGKVTYKDSTSNPLSVDNTLWANTVLASSGFCIACVVYTGRDTRQAMNTTTAKVKTGLLELEINSISKILCACVFALSILLVAFAGFHNDDWYIDILRYLILFSTIIPVSLRVNLDLAKSVYAHQIEHDKTIPETIVRTSTIPEDLGRIEYLLSDKTGTLTQNDMQLKKIHLGTVSYTSETLDIVSDYVQSLVSSKNDSLNNSKVALSTTRKDMSFRVRDMILTLAICHNVTPTFEDDELTYQAASPDEIAIVKFTESVGLSLFKRDRHSISLLHEHSGKTLNYEILQVFPFNSDSKRMGIIVRDEQLDEYWFMQKGADTVMSKIVESNDWLEEETGNMAREGLRTLVIGRKKLNKKIYEQFQKEYNDASLSMLNRDQQMSQVITKYLEHDLELLGLTGVEDKLQKDVKSSIELLRNAGIKIWMLTGDKVETARCVSISAKLISRGQYVHTITKVTRPEGAFNQLEYLKINRNACLLIDGESLGMFLKHYEQEFFDVVVHLPTVIACRCTPQQKADVALVIRKMTGKRVCCIGDGGNDVSMIQCADVGVGIVGKEGKQASLAADFSITQFCHLTELLLWHGRNSYKRSAKLAQFVMHRGLIIAICQAVYSICSLFEPIALYQGWLMVGYATCYTMAPVFSLTLDHDIEESLTKIYPELYKELTEGKSLSYKTFFVWVLLSLFQGSVIQLFSQAFTSLLDTDFTRMVAISFTALVVNELIMVALEIYTWNKTMLVTEIATLLFYIVSVPFLGDYFDLGYMTTVNYYAGLLVILLISIFPVWTAKAIYRRLHPPSYAKVQEFATP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Phosphorylation | --MPNPPSFKSHKQN --CCCCCCHHHHHHC | 46.71 | 30377154 | |
| 58 | Phosphorylation | EPLSKHNTVGDRESF CCHHCCCCCCCHHHC | 26.11 | 29136822 | |
| 64 | Phosphorylation | NTVGDRESFEMRTVD CCCCCHHHCCEEEHH | 27.66 | 29136822 | |
| 69 | Phosphorylation | RESFEMRTVDDLDNF HHHCCEEEHHHHCCC | 27.29 | 25371407 | |
| 77 | Phosphorylation | VDDLDNFSNHSSDSH HHHHCCCCCCCCCCC | 39.63 | 19684113 | |
| 80 | Phosphorylation | LDNFSNHSSDSHRKS HCCCCCCCCCCCCCC | 39.84 | 19684113 | |
| 81 | Phosphorylation | DNFSNHSSDSHRKSS CCCCCCCCCCCCCCC | 35.27 | 19684113 | |
| 83 | Phosphorylation | FSNHSSDSHRKSSNT CCCCCCCCCCCCCCC | 27.43 | 28152593 | |
| 87 | Phosphorylation | SSDSHRKSSNTDTHP CCCCCCCCCCCCCCC | 28.86 | 19779198 | |
| 88 | Phosphorylation | SDSHRKSSNTDTHPL CCCCCCCCCCCCCCC | 46.94 | 19779198 | |
| 90 | Phosphorylation | SHRKSSNTDTHPLMY CCCCCCCCCCCCCCC | 44.19 | 22369663 | |
| 92 | Phosphorylation | RKSSNTDTHPLMYDN CCCCCCCCCCCCCCC | 24.29 | 22369663 | |
| 97 | Phosphorylation | TDTHPLMYDNRLSQD CCCCCCCCCCCCCCC | 20.11 | 22369663 | |
| 102 | Phosphorylation | LMYDNRLSQDDNFKF CCCCCCCCCCCCCCC | 28.46 | 22369663 | |
| 108 | Ubiquitination | LSQDDNFKFTNIASS CCCCCCCCCEECCCC | 58.49 | 23749301 | |
| 110 | Phosphorylation | QDDNFKFTNIASSPP CCCCCCCEECCCCCC | 26.72 | 19779198 | |
| 114 | Phosphorylation | FKFTNIASSPPSSSN CCCEECCCCCCCCCC | 39.31 | 24961812 | |
| 115 | Phosphorylation | KFTNIASSPPSSSNN CCEECCCCCCCCCCC | 31.63 | 25752575 | |
| 118 | Phosphorylation | NIASSPPSSSNNIFS ECCCCCCCCCCCHHH | 50.19 | 27214570 | |
| 119 | Phosphorylation | IASSPPSSSNNIFSK CCCCCCCCCCCHHHH | 42.74 | 27214570 | |
| 126 | Ubiquitination | SSNNIFSKALSYLKV CCCCHHHHHHHHHHC | 42.47 | 17644757 | |
| 129 | Phosphorylation | NIFSKALSYLKVSNT CHHHHHHHHHHCCCC | 33.02 | 21440633 | |
| 137 | Ubiquitination | YLKVSNTKNWSKFGS HHHCCCCCCHHHCCC | 61.75 | 23749301 | |
| 141 | Ubiquitination | SNTKNWSKFGSPIEL CCCCCHHHCCCCCCC | 45.41 | 23749301 | |
| 141 | Acetylation | SNTKNWSKFGSPIEL CCCCCHHHCCCCCCC | 45.41 | 24489116 | |
| 144 | Phosphorylation | KNWSKFGSPIELSDQ CCHHHCCCCCCCCHH | 26.32 | 23749301 | |
| 170 | Phosphorylation | PVYDRNRYVSNELSN CCCCCCCHHCCCHHC | 16.27 | 28889911 | |
| 335 | Phosphorylation | NDLINRISITASAPE CCCEECEEEECCCCH | 15.62 | 28889911 | |
| 337 | Phosphorylation | LINRISITASAPEKS CEECEEEECCCCHHH | 14.04 | 28889911 | |
| 343 | Acetylation | ITASAPEKSIHKFLG EECCCCHHHHHHHHC | 54.36 | 24489116 | |
| 399 | Phosphorylation | RQAMNTTTAKVKTGL HHHHCCCCHHHHCCC | 23.57 | 28889911 | |
| 478 | Acetylation | AHQIEHDKTIPETIV HHHCCCCCCCCCHHE | 50.70 | 24489116 | |
| 505 | Phosphorylation | EYLLSDKTGTLTQND HHHHCCCCCCCCHHH | 40.15 | 22890988 | |
| 507 | Phosphorylation | LLSDKTGTLTQNDMQ HHCCCCCCCCHHHHC | 31.68 | 22890988 | |
| 509 | Phosphorylation | SDKTGTLTQNDMQLK CCCCCCCCHHHHCCC | 25.76 | 22890988 | |
| 547 | Phosphorylation | LVSSKNDSLNNSKVA HHHCCCCCCCCCEEE | 42.25 | 27214570 | |
| 551 | Phosphorylation | KNDSLNNSKVALSTT CCCCCCCCEEEECCC | 27.68 | 17563356 | |
| 626 | Phosphorylation | ISLLHEHSGKTLNYE HEEECCCCCCCCCEE | 38.71 | 28889911 | |
| 629 | Phosphorylation | LHEHSGKTLNYEILQ ECCCCCCCCCEEEEE | 24.62 | 28889911 | |
| 632 | Phosphorylation | HSGKTLNYEILQVFP CCCCCCCEEEEEEEE | 13.88 | 28889911 | |
| 642 | Phosphorylation | LQVFPFNSDSKRMGI EEEEECCCCCCCEEE | 43.57 | 28889911 | |
| 644 | Phosphorylation | VFPFNSDSKRMGIIV EEECCCCCCCEEEEE | 23.21 | 28889911 | |
| 672 | Ubiquitination | GADTVMSKIVESNDW CHHHHHHHHHHCCCH | 32.45 | 17644757 | |
| 705 | Ubiquitination | GRKKLNKKIYEQFQK CHHHHHHHHHHHHHH | 49.82 | 23749301 | |
| 780 | Phosphorylation | LTGDKVETARCVSIS EECCCCCHHHEEEEE | 23.53 | 27017623 | |
| 802 | Ubiquitination | QYVHTITKVTRPEGA CEEEEEEEECCCCCC | 37.45 | 17644757 | |
| 1017 | Phosphorylation | LTEGKSLSYKTFFVW HHCCCCCCHHHHHHH | 31.51 | 30377154 | |
| 1144 | Ubiquitination | LHPPSYAKVQEFATP HCCCCHHHHHCCCCC | 35.90 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of ATC7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of ATC7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of ATC7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64; SER-102; SER-115 ANDSER-551, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-551, AND MASSSPECTROMETRY. | |
| "Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102, AND MASSSPECTROMETRY. | |
