PTM1_YEAST - dbPTM
PTM1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PTM1_YEAST
UniProt AC P32857
Protein Name Membrane protein PTM1
Gene Name PTM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 523
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein . Early endosome membrane
Multi-pass membrane protein . Copurifies with the late Golgi SNARE TLG2.
Protein Description
Protein Sequence MRVYQFCRPFQLFTCFLCYLLVFVKANKEKISQKNYQVCAGMYSKEDWKGKIDPFISFNLKKISGLSDESDPGLVVAIYDFQDFEHLGVQLPDEEMYYICDDYAIDIGICEEENRDEFIVQDVVYDPYTSTNRSLANPIMTFSQNEVGLHDTRYPIKETGFYCVTAFRSSTSTKFNAVVNFRNAYGQLAGTEINKLPLYGLLAVAYVVAMALYSFAFWKHKHELLPLQKYLLAFFVFLTAETIFVWAYYDLKNEKGDTAGIKVYMVFLSILTAGKVTFSFFLLLIIALGYGIVYPKLNKTLMRRCQMYGALTYAICIGFLIQSYLTDMEAPSPLILITLIPMALALIIFYYMIIRSMTKTVIYLKEQRQIVKLNMYKKLLYIIYASFLSVLAGSIVSSFIYVGMNTIDMIEKNWRSRFFVTDFWPTLVYFIVFVTIAFLWRPTDTSYMLAASQQLPTDPENVADFDLGDLQSFDDQDDASIITGERGIDEDDLNLNFTDDEEGHDNVNNHSQGHGPVSPSPTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
61AcetylationPFISFNLKKISGLSD
CCCEEEEEHHCCCCC		49.5224489116
132N-linked_GlycosylationYDPYTSTNRSLANPI
CCCCCCCCCHHCCCE		31.17-
165PhosphorylationETGFYCVTAFRSSTS
HHCEEEEEEEECCCC		19.2727214570
356PhosphorylationFYYMIIRSMTKTVIY
HHHHHHHHHCCHHHH		22.0130377154
363PhosphorylationSMTKTVIYLKEQRQI
HHCCHHHHHHHHHHH		13.8430377154
480PhosphorylationFDDQDDASIITGERG
CCCCCCCCEEECCCC		22.8628889911
483PhosphorylationQDDASIITGERGIDE
CCCCCEEECCCCCCC		31.1827214570
498PhosphorylationDDLNLNFTDDEEGHD
CCCCCCCCCCCCCCC		41.2821082442
511PhosphorylationHDNVNNHSQGHGPVS
CCCCCCCCCCCCCCC		39.7229136822
518PhosphorylationSQGHGPVSPSPTK--
CCCCCCCCCCCCC--		23.8521082442
520PhosphorylationGHGPVSPSPTK----
CCCCCCCCCCC----		37.3825005228
522PhosphorylationGPVSPSPTK------
CCCCCCCCC------		54.4429136822
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PTM1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PTM1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PTM1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDC1_YEASTPDC1physical
16429126
TBA1_YEASTTUB1physical
16429126
GPI17_YEASTGPI17physical
16429126
G3P3_YEASTTDH3physical
16429126
CDC48_YEASTCDC48physical
16429126
TBB_YEASTTUB2physical
16429126
HAP3_YEASTHAP3genetic
20093466
CSG2_YEASTCSG2genetic
20093466
MGMT_YEASTMGT1genetic
20093466
ATG20_YEASTATG20genetic
20093466
TRM3_YEASTTRM3genetic
20093466
MEI4_YEASTMEI4genetic
20093466
RTG2_YEASTRTG2genetic
20093466
ASK10_YEASTASK10genetic
20093466
YG3L_YEASTYGR149Wgenetic
20093466
YJY5_YEASTYJR015Wgenetic
20093466
XPT1_YEASTXPT1genetic
20093466
COX12_YEASTCOX12genetic
20093466
AVL9_YEASTAVL9genetic
20093466
GUF1_YEASTGUF1genetic
20093466
CORO_YEASTCRN1genetic
20093466
CACP_YEASTCAT2genetic
20093466
BCH1_YEASTBCH1genetic
20093466
PET8_YEASTPET8genetic
20093466
COQ7_YEASTCAT5genetic
20093466
CWC27_YEASTCWC27genetic
20093466
SUR1_YEASTSUR1genetic
20093466
ARL3_YEASTARL3genetic
20093466
ACE2_YEASTACE2genetic
27708008
HAP3_YEASTHAP3genetic
27708008
GPR1_YEASTGPR1genetic
27708008
TRM3_YEASTTRM3genetic
27708008
ATG20_YEASTATG20genetic
27708008
MGMT_YEASTMGT1genetic
27708008
MEI4_YEASTMEI4genetic
27708008
RTG2_YEASTRTG2genetic
27708008
ERV29_YEASTERV29genetic
27708008
GPP1_YEASTGPP1genetic
27708008
IST3_YEASTIST3genetic
27708008
YJY5_YEASTYJR015Wgenetic
27708008
EMC2_YEASTEMC2genetic
27708008
XPT1_YEASTXPT1genetic
27708008
GUF1_YEASTGUF1genetic
27708008
FKS1_YEASTFKS1genetic
27708008
RL31B_YEASTRPL31Bgenetic
27708008
YL407_YEASTYLR407Wgenetic
27708008
CORO_YEASTCRN1genetic
27708008
RTC1_YEASTRTC1genetic
27708008
CY1_YEASTCYT1genetic
27708008
AZF1_YEASTAZF1genetic
27708008
COQ7_YEASTCAT5genetic
27708008
ARL3_YEASTARL3genetic
27708008
SUR1_YEASTSUR1genetic
27708008
CWC27_YEASTCWC27genetic
27708008
YP097_YEASTYPR097Wgenetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PTM1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-480; THR-483 ANDTHR-498, AND MASS SPECTROMETRY.

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