CWC27_YEAST - dbPTM
CWC27_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CWC27_YEAST
UniProt AC Q02770
Protein Name Peptidyl-prolyl isomerase CWC27
Gene Name CWC27
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 301
Subcellular Localization Cytoplasm . Nucleus .
Protein Description PPIases accelerate the folding of proteins. Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing. [PubMed: 11884590]
Protein Sequence MSSNIEPQTTAKCILYTTKGNIAIELWAKECPETCKRFLSMLSDGTFTNGEFKELKPTQWLMFNANSTGEYRTVAEEKNPRIRFNRDGLLGWDRRRNTWFITVLADSKHVLNDCNVFGKIVGKSIYIFREILGGEIEASSRDNDVKRFMYPAVLKDVEITIPFFEDIFGSKRRLEDNEKKEQEPAKKLVKSAKVKMVYEDEQEDDDGDVQKLKPRKRMILPAWIKDDSRSEGIKLDASLDQPQEALIREKTELHDNVDEATTKETESQENIKEEPMDKRERETLAMLSKFQERIKNKNILK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
211AcetylationDDDGDVQKLKPRKRM
CCCCCHHHCCCCCEE
59.3224489116
251PhosphorylationEALIREKTELHDNVD
HHHHHHHHHHCCCCC
38.7425704821
265PhosphorylationDEATTKETESQENIK
CHHHHHHHHHHHCHH
42.3624961812
267PhosphorylationATTKETESQENIKEE
HHHHHHHHHHCHHCC
50.6521440633
289AcetylationETLAMLSKFQERIKN
HHHHHHHHHHHHHHC
47.2924489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CWC27_YEAST !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CWC27_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CWC27_YEAST !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PML1_YEASTPML1genetic
19061648
POP8_YEASTPOP8genetic
19061648
CWC26_YEASTBUD13genetic
19061648
IST3_YEASTIST3genetic
19061648
NCBP1_YEASTSTO1genetic
19061648
ERF3_YEASTSUP35genetic
19061648
DOA1_YEASTDOA1genetic
19061648
PFD2_YEASTGIM4genetic
19061648
PP12_YEASTGLC7genetic
19061648
SSB1_YEASTSSB1physical
19536198
LTE1_YEASTLTE1genetic
27708008
WHI4_YEASTWHI4genetic
27708008
CWC26_YEASTBUD13genetic
27708008
SKN1_YEASTSKN1genetic
27708008
IST3_YEASTIST3genetic
27708008
DAL81_YEASTDAL81genetic
27708008
PHD1_YEASTPHD1genetic
27708008
PML1_YEASTPML1genetic
27708008
VAM3_YEASTVAM3genetic
27708008
SUCA_YEASTLSC1genetic
27708008

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CWC27_YEAST

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Related Literatures of Post-Translational Modification

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