| UniProt ID | NCBP1_YEAST | |
|---|---|---|
| UniProt AC | P34160 | |
| Protein Name | Nuclear cap-binding protein complex subunit 1 | |
| Gene Name | STO1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 861 | |
| Subcellular Localization | Nucleus . Cytoplasm, perinuclear region . Predominantly nuclear, is able to exit the nucleus in an RNA-dependent manner. | |
| Protein Description | Component of the CBC complex, which binds co-transcriptionally to the 5'-cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.. | |
| Protein Sequence | MFNRKRRGDFDEDENYRDFRPRMPKRQRIPPVVQLCKEMMPDIRTIGESVKAFEDDIKFLSEAIMNEYGHEDYFNNALLSTLNAVVVEQPQKQAAIALLTMVVNSKNNVAGKSIINYFFEELQKWCKQTYNDEFKSTSNETGPWNKIKLILRFLSILSPMFLVDELINIYKSLFELSIELNNLDPGNRVPLSEAIYTNTLLNIPYLFFFNRNNDGLRTKVEELLAYVEQNYLVKTTDINLLREYNGEPPYEMVELVRVVLPNVKKALINNLEQLNELFPDWNHLLTPQTGDEGFNDALTLPSVDDLKSFVRLNKNFGSVDSMWKTPRYAFHVYLPNSAGNFETVVPISTYAGQLFNDIIIDLVESLEFNRKEVARQVITLDLFFKAGIFTEPGESIAQLIATYEENPLAPTFKIEDLAIETILGLIFKLPSVSQPFAYFYTLLVDICQNSPKAIAPVFGRAFRFFYSHLDSLDFELKLRYLDWFSIQMSNFNFSWKWNEWEDDSIKFGKYFYNPKVNFAKNLIQKELRLTSNFSEVEDSLPQEFTKYLDTSYIPRDQLINYYQSLFTGYTVEEDSVRKNDLYFRQEGVPMENTVRKILDYTHKANNSREVTELESILGELKNEYGSIISDFNRFVIILLVQAVTDSGSRSLSHANKYINDLKEDLKTIFAKIELDIETKEYIIIEAVLTFWNANPQTGFLVADAFKYAGLLTSRTIFTFIFNETGLKNNGLIEATAIEAVFRNLSQQISEENESGNNFEFVFERLCTIANSTIDLLDVNADEDIEIPKVNGEMDIDDIEDDKLDLKWKYFTVIGFIKSILRRYSHEYRELADKFIANIDNAIPHESTRRTISNWIQETKEV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 127 | Acetylation | EELQKWCKQTYNDEF HHHHHHHHHHCCHHH | 44.55 | 24489116 | |
| 196 | Phosphorylation | VPLSEAIYTNTLLNI CCHHHHHHHCCCCCC | 10.86 | 27017623 | |
| 197 | Phosphorylation | PLSEAIYTNTLLNIP CHHHHHHHCCCCCCC | 18.66 | 27017623 | |
| 199 | Phosphorylation | SEAIYTNTLLNIPYL HHHHHHCCCCCCCEE | 25.48 | 27017623 | |
| 205 | Phosphorylation | NTLLNIPYLFFFNRN CCCCCCCEEEEECCC | 16.61 | 27017623 | |
| 324 | Acetylation | GSVDSMWKTPRYAFH CCCCCCCCCCEEEEE | 39.76 | 24489116 | |
| 324 | Ubiquitination | GSVDSMWKTPRYAFH CCCCCCCCCCEEEEE | 39.76 | 24961812 | |
| 480 | Phosphorylation | DFELKLRYLDWFSIQ CCEEEHHHEEEEEEE | 21.32 | 28889911 | |
| 485 | Phosphorylation | LRYLDWFSIQMSNFN HHHEEEEEEEECCCC | 13.99 | 28889911 | |
| 489 | Phosphorylation | DWFSIQMSNFNFSWK EEEEEEECCCCCEEE | 23.15 | 28889911 | |
| 509 | Acetylation | DDSIKFGKYFYNPKV CCCCEEHHHCCCCCC | 35.01 | 22865919 | |
| 515 | Ubiquitination | GKYFYNPKVNFAKNL HHHCCCCCCHHHHHH | 46.29 | 24961812 | |
| 520 | Ubiquitination | NPKVNFAKNLIQKEL CCCCHHHHHHHHHHH | 48.42 | 23749301 | |
| 525 | Ubiquitination | FAKNLIQKELRLTSN HHHHHHHHHHHHCCC | 52.28 | 23749301 | |
| 601 | Phosphorylation | VRKILDYTHKANNSR HHHHHHHHHHCCCCC | 19.30 | 27017623 | |
| 611 | Phosphorylation | ANNSREVTELESILG CCCCCHHHHHHHHHH | 30.05 | 27017623 | |
| 615 | Phosphorylation | REVTELESILGELKN CHHHHHHHHHHHHHH | 35.42 | 27017623 | |
| 629 | Phosphorylation | NEYGSIISDFNRFVI HHHHCHHHHHHHHHH | 34.18 | 28889911 | |
| 656 | Acetylation | RSLSHANKYINDLKE CCHHHHHHHHHHHHH | 48.57 | 24489116 | |
| 662 | Succinylation | NKYINDLKEDLKTIF HHHHHHHHHHHHHHH | 52.63 | 23954790 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of NCBP1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of NCBP1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of NCBP1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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