PRP5_YEAST - dbPTM
PRP5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PRP5_YEAST
UniProt AC P21372
Protein Name Pre-mRNA-processing ATP-dependent RNA helicase PRP5
Gene Name PRP5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 849
Subcellular Localization Nucleus .
Protein Description ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA..
Protein Sequence METIDSKQNINRESLLEERRKKLAKWKQKKAQFDAQKEHQTSRNDIVTNSLEGKQTTEKFTERQERVKEELRKRKNEFRKSDEPVSVKPSKKKSKRSKVKKKISFDFSDDDDSEIGVSFRSKEHIQKAPEHDNEKDPLDEFMTSLKEEKMSNSKGMYDRGDILDVEDQLFELGGTDDEDVEDNTDNSNIAKIAKLKAKKRVKQIYYSPEELEPFQKNFYIESETVSSMSEMEVEELRLSLDNIKIKGTGCPKPVTKWSQLGLSTDTMVLITEKLHFGSLTPIQSQALPAIMSGRDVIGISKTGSGKTISYLLPLLRQVKAQRPLSKHETGPMGLILAPTRELALQIHEEVTKFTEADTSIRSVCCTGGSEMKKQITDLKRGTEIVVATPGRFIDILTLNDGKLLSTKRITFVVMDEADRLFDLGFEPQITQIMKTVRPDKQCVLFSATFPNKLRSFAVRVLHSPISITINSKGMVNENVKQKFRICHSEDEKFDNLVQLIHERSEFFDEVQSENDGQSSDVEEVDAKAIIFVSSQNICDFISKKLLNAGIVTCAIHAGKPYQERLMNLEKFKREKNSILLCTEVLSRGLNVPEVSLVIIYNAVKTFAQYVHTTGRTARGSRSGTAITLLLHDELSGAYILSKAMRDEEIKALDPLQAKELQEMSAKFESGMKKGKFRLSKGFGGKGLENIKSKREEAQNKDLELKKNDKRSDDLEKKISNPREGHDSVSESSALIPRLNYELFKESTDGSIIFYAKVYINDLPQIVRWEATKNTTLLFIKHETGCSITNKGKFYPEGKEPKNENDEPKLYLLIEGQDEKDIQLSIELLEQKVKEGVVKAASLSLKSTKY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59AcetylationEGKQTTEKFTERQER
CCCHHHHHHHHHHHH		56.3325381059
175PhosphorylationQLFELGGTDDEDVED
HHHHCCCCCHHHCCC		38.1821440633
430PhosphorylationLGFEPQITQIMKTVR
CCCCHHHHHHHHHCC		13.5421126336
504PhosphorylationVQLIHERSEFFDEVQ
HHHHHHHHHHHHHHH		35.4519795423
512PhosphorylationEFFDEVQSENDGQSS
HHHHHHHCCCCCCCC		43.4723749301
518PhosphorylationQSENDGQSSDVEEVD
HCCCCCCCCCCHHCC		33.7523749301
519PhosphorylationSENDGQSSDVEEVDA
CCCCCCCCCCHHCCC		37.4823749301
685AcetylationLSKGFGGKGLENIKS
ECCCCCCHHHHHHHH		61.7825381059
727PhosphorylationNPREGHDSVSESSAL
CCCCCCCCCCHHHCH		23.1319779198
729PhosphorylationREGHDSVSESSALIP
CCCCCCCCHHHCHHH		35.4019779198
746PhosphorylationNYELFKESTDGSIIF
CHHHHHCCCCCCEEE		32.1826447709
747PhosphorylationYELFKESTDGSIIFY
HHHHHCCCCCCEEEE		45.5326447709
750PhosphorylationFKESTDGSIIFYAKV
HHCCCCCCEEEEEEE		18.4726447709
754PhosphorylationTDGSIIFYAKVYIND
CCCCEEEEEEEEECC		8.6326447709
845AcetylationKAASLSLKSTKY---
HHHHHHCCCCCC---		53.3425381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PRP5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PRP5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PRP5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNF11_YEASTSNF11physical
10688190
SF3B1_YEASTHSH155physical
16314500
CUS1_YEASTCUS1genetic
8566755
CUS2_YEASTCUS2genetic
18082608
FYV4_YEASTFYV4physical
18467557
SYC1_YEASTSYC1genetic
19061648
GTS1_YEASTGTS1physical
19451545
CUS2_YEASTCUS2genetic
20471947
CUS2_YEASTCUS2genetic
24560925
XPO1_YEASTCRM1genetic
27708008
KTHY_YEASTCDC8genetic
27708008
RNT1_YEASTRNT1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
PABC_YEASTABZ2genetic
27708008
GAS1_YEASTGAS1genetic
27708008
RL21B_YEASTRPL21Bgenetic
27708008
PRP9_YEASTPRP9genetic
27708008
PRP11_YEASTPRP11genetic
27708008
UBC9_YEASTUBC9genetic
27708008
LUC7_YEASTLUC7genetic
27708008
YRB1_YEASTYRB1genetic
27708008
RPC10_YEASTRPC11genetic
27708008
UBC3_YEASTCDC34genetic
27708008
RS13_YEASTRPS13genetic
27708008
ERF3_YEASTSUP35genetic
27708008
PRP28_YEASTPRP28genetic
27708008
GPI19_YEASTGPI19genetic
27708008
ACT_YEASTACT1genetic
27708008
NU145_YEASTNUP145genetic
27708008
PTI1_YEASTPTI1genetic
27708008
DNA2_YEASTDNA2genetic
27708008
BET1_YEASTBET1genetic
27708008
PAN1_YEASTPAN1genetic
27708008
PRI1_YEASTPRI1genetic
27708008
DPB11_YEASTDPB11genetic
27708008
PRP21_YEASTPRP21genetic
27708008
ESS1_YEASTESS1genetic
27708008
NUP85_YEASTNUP85genetic
27708008
CWC16_YEASTYJU2genetic
27708008
YKT6_YEASTYKT6genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
CLF1_YEASTCLF1genetic
27708008
SEC22_YEASTSEC22genetic
27708008
RU1C_YEASTYHC1genetic
27708008
TAD3_YEASTTAD3genetic
27708008
IMB1_YEASTKAP95genetic
27708008
RSE1_YEASTRSE1genetic
27708008
POB3_YEASTPOB3genetic
27708008
CUS1_YEASTCUS1genetic
27708008
CAP_YEASTSRV2genetic
27708008
SEC12_YEASTSEC12genetic
27708008
SEC63_YEASTSEC63genetic
27708008
RPA1_YEASTRPA190genetic
27708008
TBF1_YEASTTBF1genetic
27708008
IPL1_YEASTIPL1genetic
27708008
ARP7_YEASTARP7genetic
27708008
RDS3_YEASTRDS3genetic
27708008
BUR1_YEASTSGV1genetic
27708008
NUP60_YEASTNUP60genetic
27708008
RS14A_YEASTRPS14Agenetic
27708008
SAC3_YEASTSAC3genetic
27708008
H2A1_YEASTHTA1genetic
27708008
RT103_YEASTRTT103genetic
27708008
CWC26_YEASTBUD13genetic
27708008
OCA5_YEASTOCA5genetic
27708008
NAM8_YEASTNAM8genetic
27708008
MRT4_YEASTMRT4genetic
27708008
MUD2_YEASTMUD2genetic
27708008
CTK1_YEASTCTK1genetic
27708008
EIF3J_YEASTHCR1genetic
27708008
NUP2_YEASTNUP2genetic
27708008
YL456_YEASTYLR456Wgenetic
27708008
MAS5_YEASTYDJ1genetic
27708008
YNO0_YEASTYNL140Cgenetic
27708008
MSB4_YEASTMSB4genetic
27708008
STI1_YEASTSTI1genetic
27708008
FYV12_YEASTFYV12genetic
27708008
LIPA_YEASTLIP5genetic
27708008
RUD3_YEASTRUD3genetic
27708008
SNC2_YEASTSNC2genetic
27708008
TGS1_YEASTTGS1genetic
27708008
NCBP2_YEASTCBC2genetic
27708008
RU2A_YEASTLEA1genetic
27708008
BRR1_YEASTBRR1genetic
27708008
YP089_YEASTYPR089Wgenetic
27708008
RU2A_YEASTLEA1physical
25561497
SF3B1_YEASTHSH155physical
28062854
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PRP5_YEAST

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Related Literatures of Post-Translational Modification

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