| UniProt ID | CUS1_YEAST | |
|---|---|---|
| UniProt AC | Q02554 | |
| Protein Name | Cold sensitive U2 snRNA suppressor 1 | |
| Gene Name | CUS1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 436 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Essential splicing protein required for U2 snRNP binding to pre-mRNA during spliceosome assembly.. | |
| Protein Sequence | MARTKSRKRSGNNQNKNASVVNNKAEIAAMIDARRLEQKKKGGVTNSKGKTNKVVDAKLEKEFKDVLQRFQVQENDTPKEITKDEKNNHVVIVEKNPVMNRKHTAEDELEDTPSDGIEEHLSARKRRKTEKPSLSQLKSQVPYPQIIEWYDCDARYPGLLASIKCTKNVIPVPSHWQSKKEYLSGRSLLGKRPFELPDIIKKTNIEQMRSTLPQSGLDGQDEKSLKEASRARVQPKMGALDLDYKKLHDVFFKIGANWKPDHLLCFGDVYYENRNLFEETNWKRMVDHKRPGRISQELRAIMNLPEGQLPPWCMKMKDIGLPTGYPDLKIAGLNWDITNLKGDVYGKIIPNHHSRSKKQGRNYFGALISFETPEFENSKEDTQANAENGRQDDKIDDEVEHKLDHFQEDISEVTSAEEKLERNEEESEKQLYTVLK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 95 | Acetylation | NHVVIVEKNPVMNRK CEEEEEECCCCCCCC | 56.51 | 24489116 | |
| 104 | Phosphorylation | PVMNRKHTAEDELED CCCCCCCCCCHHHCC | 34.47 | 27214570 | |
| 112 | Phosphorylation | AEDELEDTPSDGIEE CCHHHCCCCCCCHHH | 18.47 | 20377248 | |
| 114 | Phosphorylation | DELEDTPSDGIEEHL HHHCCCCCCCHHHHH | 51.03 | 19823750 | |
| 122 | Phosphorylation | DGIEEHLSARKRRKT CCHHHHHHHHHHCCC | 28.12 | 19779198 | |
| 129 | Phosphorylation | SARKRRKTEKPSLSQ HHHHHCCCCCCCHHH | 47.64 | 28889911 | |
| 133 | Phosphorylation | RRKTEKPSLSQLKSQ HCCCCCCCHHHHHHC | 52.28 | 28889911 | |
| 135 | Phosphorylation | KTEKPSLSQLKSQVP CCCCCCHHHHHHCCC | 37.49 | 28889911 | |
| 224 | Phosphorylation | LDGQDEKSLKEASRA CCCCCHHHHHHHHHH | 42.50 | 19823750 | |
| 229 | Phosphorylation | EKSLKEASRARVQPK HHHHHHHHHHHCCCC | 27.80 | 19823750 | |
| 411 | Phosphorylation | DHFQEDISEVTSAEE HHHHHHHHHCCCHHH | 38.03 | 19795423 | |
| 414 | Phosphorylation | QEDISEVTSAEEKLE HHHHHHCCCHHHHHH | 20.40 | 19795423 | |
| 415 | Phosphorylation | EDISEVTSAEEKLER HHHHHCCCHHHHHHH | 38.57 | 19795423 | |
| 429 | Acetylation | RNEEESEKQLYTVLK HCHHHHHHHHHHHHC | 55.68 | 22865919 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CUS1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CUS1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CUS1_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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