| UniProt ID | PRP21_YEAST | |
|---|---|---|
| UniProt AC | P32524 | |
| Protein Name | Pre-mRNA-splicing factor PRP21 | |
| Gene Name | PRP21 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 280 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | mRNA splicing factors, PRP9, PRP11, and PRP21, are necessary for binding of the U2 snRNP to the pre-mRNA in an early step of spliceosome assembly.. | |
| Protein Sequence | MEPEDTQLKEDIKTTVNYIKQHGVEFENKLLEDERFSFIKKDDPLHEYYTKLMNEPTDTVSGEDNDRKSEREIARPPDFLFSQYDTGISRRDMEVIKLTARYYAKDKSIVEQMISKDGEARLNFMNSSHPLHKTFTDFVAQYKRVYSFTGQEIKKSKRTILDNCFERTQYWEFEKDKDREHDKLVELCKIQFAAIPWDKFTQVAKFSIPEDTEIFEGSLDLEQMRLRRVQTGIKLFDSIKPTNEEEKIVSDQGKQKGGDSKGKKRKIRAVGETRLKKSKK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 57 | Phosphorylation | TKLMNEPTDTVSGED HHHHCCCCCCCCCCC | 37.82 | 22369663 | |
| 59 | Phosphorylation | LMNEPTDTVSGEDND HHCCCCCCCCCCCCC | 21.03 | 20377248 | |
| 61 | Phosphorylation | NEPTDTVSGEDNDRK CCCCCCCCCCCCCHH | 38.26 | 22369663 | |
| 69 | Phosphorylation | GEDNDRKSEREIARP CCCCCHHHHHHHCCC | 42.66 | 28889911 | |
| 82 | Phosphorylation | RPPDFLFSQYDTGIS CCCCCCCCCCCCCCC | 29.94 | 28889911 | |
| 108 | Phosphorylation | RYYAKDKSIVEQMIS HHHHCCHHHHHHHHC | 41.84 | 27017623 | |
| 143 | Acetylation | TDFVAQYKRVYSFTG HHHHHHHHHHHHCCH | 24.25 | 24489116 | |
| 146 | Phosphorylation | VAQYKRVYSFTGQEI HHHHHHHHHCCHHHH | 11.33 | 28132839 | |
| 147 | Phosphorylation | AQYKRVYSFTGQEIK HHHHHHHHCCHHHHH | 17.30 | 28889911 | |
| 156 | Phosphorylation | TGQEIKKSKRTILDN CHHHHHHCCCCHHHH | 23.51 | 21551504 | |
| 159 | Phosphorylation | EIKKSKRTILDNCFE HHHHCCCCHHHHHHH | 29.63 | 21551504 | |
| 168 | Phosphorylation | LDNCFERTQYWEFEK HHHHHHHHHHCCCCC | 20.86 | 21551504 | |
| 250 | Phosphorylation | NEEEKIVSDQGKQKG CHHHCCCCCCCCCCC | 27.91 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRP21_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRP21_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRP21_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-61; SER-147 AND SER-250,AND MASS SPECTROMETRY. | |
