dbPTM

TRM44_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRM44_YEAST
UniProt AC	Q02648
Protein Name	tRNA (uracil-O(2)-)-methyltransferase
Gene Name	TRM44
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	567
Subcellular Localization	Cytoplasm .
Protein Description	tRNA (uracil-O(2)-)-methyltransferase, which catalyzes the formation of O(2)-methyluracil at position 44 (Um44) in tRNA(Ser)..
Protein Sequence	MTGDGSAHISKNNQNQHKDRFKFIVNDKSILGPQWLSLYQTDGKVTFAKSHFEQAMMNVIREPNINSTVILRADILKEINHAAEAGSEPKFDESVLKKFEIDNGNESGEEDVKKINIEDLNIRSCETSESLKLSPVHEFVRRIIPRNFYKDAIINQTCLILNSKDPNFQETSLIVYTPHINSEKDCPFYIPRTQSVGILLHQSVLSVHYIPFPEDKTAFTDESERVVRTAYRLLQTANKHSKGVMQGYEKRVNHDQVVNKVNFQNTYIVLKKKYSKFLVENWAESTDPKKHVFEDIAIAAFLIELWIKVYGPDFRSKMQFRDLGCGNGALCYILLSESIKGLGIDARKRKSWSIYPPEVQSSLKEQVIIPSILLRPHPALKRQVPHLEHNGRFFPVKVTHEVIAPATVVYSSEDLLKSPQVNTAEFPPDTFIIGNHSDELTCWIPLLGHPYMVIPCCSHNFSGQRVRFNVRKRSPRSNEIKNQNNSKSTYSGLVDHVEYISSRVGWKVEKEMLRIPSTRNAAIIGVENATLKHFPTQAVYDMIWEDGGAEGWIQNTMSLLKRNPRNH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Acetylation	NQHKDRFKFIVNDKS CCCCCCEEEEECCCC	34.77	24489116
87	Phosphorylation	NHAAEAGSEPKFDES HHHHHCCCCCCCCHH	58.75	30377154
107	Phosphorylation	EIDNGNESGEEDVKK EECCCCCCCCHHHHH	56.35	22369663

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRM44_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRM44_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRM44_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAN1_YEAST	TAN1	genetic	18025252
MET22_YEAST	MET22	genetic	18443146
PAP2_YEAST	PAP2	genetic	18443146
RRP6_YEAST	RRP6	genetic	18443146
XRN2_YEAST	RAT1	genetic	18443146
EF1A_YEAST	TEF2	genetic	22895820
SLX5_YEAST	SLX5	genetic	27708008
RL8A_YEAST	RPL8A	genetic	27708008
ESP1_YEAST	ESP1	genetic	27708008
NU192_YEAST	NUP192	genetic	27708008
CET1_YEAST	CET1	genetic	27708008
RM01_YEAST	MRPL1	genetic	27708008
SWR1_YEAST	SWR1	genetic	27708008
HOS2_YEAST	HOS2	genetic	27708008
PBS2_YEAST	PBS2	genetic	27708008
RM49_YEAST	MRP49	genetic	27708008
DCOR_YEAST	SPE1	genetic	27708008
DBP7_YEAST	DBP7	genetic	27708008
PAM17_YEAST	PAM17	genetic	27708008
HOG1_YEAST	HOG1	genetic	27708008
UPS2_YEAST	UPS2	genetic	27708008
ELO3_YEAST	ELO3	genetic	27708008
CDC73_YEAST	CDC73	genetic	27708008
RM39_YEAST	MRPL39	genetic	27708008
COX7_YEAST	COX7	genetic	27708008
SAP30_YEAST	SAP30	genetic	27708008
CPT1_YEAST	CPT1	genetic	27708008
COQ2_YEAST	COQ2	genetic	27708008
DCAM_YEAST	SPE2	genetic	27708008
PT127_YEAST	PET127	genetic	27708008
MNE1_YEAST	MNE1	genetic	27708008
MSC6_YEAST	MSC6	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRM44_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND MASSSPECTROMETRY.	18407956 [Abstract]
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND MASSSPECTROMETRY.	17563356 [Abstract]
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae."; Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.; J. Proteome Res. 6:1190-1197(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-107, AND MASSSPECTROMETRY.	17330950 [Abstract]