| UniProt ID | PAP2_YEAST | |
|---|---|---|
| UniProt AC | P53632 | |
| Protein Name | Poly(A) RNA polymerase protein 2 | |
| Gene Name | PAP2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 584 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Catalytic subunit of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. TRF4 is also required for proper nuclear division in mitosis, DNA damage repair and sister chromatid cohesion. Involved in the regulation of histone mRNA levels. May mediate mitotic chromosome condensation.. | |
| Protein Sequence | MGAKSVTASSSKKIKNRHNGKVKKSKKIKKVRKPQKSISLNDENEVEILPSRNEQETNKLPKDHVTADGILVLEHKSDDDEGFDVYDGHFDNPTDIPSTTEESKTPSLAVHGDEKDLANNDDFISLSASSEDEQAEQEEEREKQELEIKKEKQKEILNTDYPWILNHDHSKQKEISDWLTFEIKDFVAYISPSREEIEIRNQTISTIREAVKQLWPDADLHVFGSYSTDLYLPGSDIDCVVTSELGGKESRNNLYSLASHLKKKNLATEVEVVAKARVPIIKFVEPHSGIHIDVSFERTNGIEAAKLIREWLDDTPGLRELVLIVKQFLHARRLNNVHTGGLGGFSIICLVFSFLHMHPRIITNEIDPKDNLGVLLIEFFELYGKNFGYDDVALGSSDGYPVYFPKSTWSAIQPIKNPFSLAIQDPGDESNNISRGSFNIRDIKKAFAGAFDLLTNRCFELHSATFKDRLGKSILGNVIKYRGKARDFKDERGLVLNKAIIENENYHKKRSRIIHDEDFAEDTVTSTATATTTDDDYEITNPPAKKAKIEEKPESEPAKRNSGETYITVSSEDDDEDGYNPYTL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MGAKSVTASSSK ---CCCCCCCCCCCH | 24.94 | 19823750 | |
| 7 | Phosphorylation | -MGAKSVTASSSKKI -CCCCCCCCCCCHHH | 28.10 | 19823750 | |
| 9 | Phosphorylation | GAKSVTASSSKKIKN CCCCCCCCCCHHHHH | 26.27 | 19823750 | |
| 10 | Phosphorylation | AKSVTASSSKKIKNR CCCCCCCCCHHHHHC | 43.65 | 19823750 | |
| 11 | Phosphorylation | KSVTASSSKKIKNRH CCCCCCCCHHHHHCC | 35.16 | 19823750 | |
| 12 | Acetylation | SVTASSSKKIKNRHN CCCCCCCHHHHHCCC | 61.54 | 25381059 | |
| 39 | Phosphorylation | RKPQKSISLNDENEV CCCCCCCCCCCCCCE | 28.36 | 30377154 | |
| 59 | Acetylation | RNEQETNKLPKDHVT CCHHHCCCCCCCCCC | 73.85 | 25381059 | |
| 66 | Phosphorylation | KLPKDHVTADGILVL CCCCCCCCCCEEEEE | 18.66 | 24961812 | |
| 77 | Phosphorylation | ILVLEHKSDDDEGFD EEEEEECCCCCCCCC | 48.45 | 25704821 | |
| 86 | Phosphorylation | DDEGFDVYDGHFDNP CCCCCCCCCCCCCCC | 20.32 | 24961812 | |
| 94 | Phosphorylation | DGHFDNPTDIPSTTE CCCCCCCCCCCCCCC | 53.46 | 24961812 | |
| 105 | Phosphorylation | STTEESKTPSLAVHG CCCCCCCCCCEEECC | 27.65 | 28889911 | |
| 125 | Phosphorylation | ANNDDFISLSASSED CCCCCCEECCCCCHH | 19.10 | 19823750 | |
| 127 | Phosphorylation | NDDFISLSASSEDEQ CCCCEECCCCCHHHH | 21.22 | 21440633 | |
| 129 | Phosphorylation | DFISLSASSEDEQAE CCEECCCCCHHHHHH | 30.77 | 21440633 | |
| 130 | Phosphorylation | FISLSASSEDEQAEQ CEECCCCCHHHHHHH | 49.10 | 21440633 | |
| 171 | Acetylation | ILNHDHSKQKEISDW HHCCCHHHCCCHHHH | 63.07 | 24489116 | |
| 225 | Phosphorylation | ADLHVFGSYSTDLYL CCEEEEEEEECCEEC | 12.40 | 30377154 | |
| 226 | Phosphorylation | DLHVFGSYSTDLYLP CEEEEEEEECCEECC | 18.90 | 30377154 | |
| 227 | Phosphorylation | LHVFGSYSTDLYLPG EEEEEEEECCEECCC | 19.69 | 30377154 | |
| 228 | Phosphorylation | HVFGSYSTDLYLPGS EEEEEEECCEECCCC | 23.07 | 30377154 | |
| 231 | Phosphorylation | GSYSTDLYLPGSDID EEEECCEECCCCCCC | 17.41 | 30377154 | |
| 250 | Phosphorylation | SELGGKESRNNLYSL CCCCCCCHHCCHHHH | 43.74 | 26447709 | |
| 255 | Phosphorylation | KESRNNLYSLASHLK CCHHCCHHHHHHHHH | 12.08 | 26447709 | |
| 256 | Phosphorylation | ESRNNLYSLASHLKK CHHCCHHHHHHHHHH | 22.18 | 26447709 | |
| 259 | Phosphorylation | NNLYSLASHLKKKNL CCHHHHHHHHHHCCC | 34.35 | 26447709 | |
| 275 | Ubiquitination | TEVEVVAKARVPIIK CEEEHHHCCCCCEEE | 25.72 | 24961812 | |
| 389 | Phosphorylation | LYGKNFGYDDVALGS HHCCCCCCCCCEECC | 12.58 | 28889911 | |
| 416 | Acetylation | WSAIQPIKNPFSLAI CCCCCCCCCCCEEEE | 66.31 | 22865919 | |
| 562 | Phosphorylation | SEPAKRNSGETYITV CCCCCCCCCCCEEEE | 41.88 | 21551504 | |
| 570 | Phosphorylation | GETYITVSSEDDDED CCCEEEECCCCCCCC | 21.25 | 20377248 | |
| 571 | Phosphorylation | ETYITVSSEDDDEDG CCEEEECCCCCCCCC | 40.48 | 20377248 | |
| 579 | Phosphorylation | EDDDEDGYNPYTL-- CCCCCCCCCCCCC-- | 25.86 | 20377248 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PAP2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PAP2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PAP2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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