| UniProt ID | SKI3_YEAST | |
|---|---|---|
| UniProt AC | P17883 | |
| Protein Name | Superkiller protein 3 | |
| Gene Name | SKI3 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1432 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | Component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon.. | |
| Protein Sequence | MSDIKQLLKEAKQELTNRDYEETIEISEKVLKLDPDNYFAHIFLGKALSSLPASNNVSSNRNLERATNHYVSAAKLVPDNLLAWKGLFLLFRTTEVVPDILSYDEYFDLCGQYADALLKQEQSQVELINDIKLLKKTHPDCQKAFYQHLKPGSLMAETIGRHLSTPQDALLNLIKILSNIETTEIGKTLSQNRLKLKASDPDYQIKLNSFSWEIIKNSEIDQLYNQLVNILADDQKRSEIENQWLEYRIKVLKSMPLDVKKDFFTKVKEMVEDMVLVNHQSLLAWQKYFEWTDYEDLDNMDAPLIIKYFKKFPKDPLAMILYSWLSSKLSKYDIKSLESANKPPEGHKKTEKETDIKDVDETNEDEVKDRVEDEVKDRVEDEVKDQDEEAKEDEEEDLDDIEIGLLEEEVVTVLTENIVKCKNNILAHRILCQYYLLTKEYEAALPYIKNGISLIAYNIKDLGVHLPLTKREFSLDLATVYTYVDAPKDHNAALKLYDNILSGDFSNIQAKMGKGIIFIERKNWKDAMTLLTQVHEQSPNNLEVLSELSWSKAHMGYMDEALAGLDTVIKGIKGMDLRSIDFRALNLWRQAKVYIMKHASINDAKQENVKCAFKLLIQSIKILDTFAPGFSTLGDIYCHYYKDHLRAFKCYFKAFDLDAGDYTAAKYITETYASKPNWQAASSIASRLIKGEKAKAELRSNNWPFRVVGIAHLEKQEESDSIEWFQSALRVDPNDVESWVGLGQAYHACGRIEASIKVFDKAIQLRPSHTFAQYFKAISLCDVGEYLESLDILEKVCQEAATEESFQIGLVEVLMRCSLDLYSQGFLLKSVSIAKDTIERIKIIISELKCENQQVWIYLSQVLRLFIWIESKVDTLPVESLVSIFENSQFSGSEEIDSVDNIKIDTLLDSTTDDNVSIACKFLILASKYSVSDQKFTDIAGTVRASYWYNIGISELTAFITLKEPQYRDAAIFAFKKSIQLQSNTSETWIGLGIATMDINFRVSQHCFIKATALEPKATNTWFNLAMLGLKKKDTEFAQQVLNKLQSLAPQDSSPWLGMALILEEQGDIIGSSKLFAHSFILSNGRSKAAQFMYAKNVLENHINNGDDERDIETVEKLTTASIALEQFFKKSPDSQFALQCALLTLERLHHYENANELANRLIGILEKKFEKTQDERELFNFAIIKGQFARIHLGLGNFELSIENADLSQGIISESSDEKSMKTKISNHICLGLSYFFLNDFDQTLNQFQELLSISKDSKHLVVLIAKVLYDVGESDTKEIALQELTEYIATSGADLLVTLTIAAMSILDDKREDLSIILEELKALPLSKQIIDKHKDAPYLIEEITKRLYRNDTGKQVWQRSAYFFPNNLKVWERLDKNIQRRIASNGQNKVTAEEMSKLYCESKNLRSIQRGMFLCPWNVTAVKALNECF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 150 | Acetylation | KAFYQHLKPGSLMAE HHHHHHCCCCCCHHH | 45.25 | 24489116 | |
| 197 | Ubiquitination | SQNRLKLKASDPDYQ HHCCEEEECCCCCHH | 44.23 | 23749301 | |
| 218 | Phosphorylation | SWEIIKNSEIDQLYN EEEHHCCCHHHHHHH | 30.81 | 28132839 | |
| 224 | Phosphorylation | NSEIDQLYNQLVNIL CCHHHHHHHHHHHHH | 8.67 | 24909858 | |
| 327 | Phosphorylation | ILYSWLSSKLSKYDI HHHHHHHHHCCCCCH | 35.13 | 27017623 | |
| 675 | Ubiquitination | ITETYASKPNWQAAS HHHHCCCCCCHHHHH | 33.91 | 23749301 | |
| 830 | Phosphorylation | SQGFLLKSVSIAKDT HCCCCHHEEEECHHH | 22.52 | 25882841 | |
| 837 | Phosphorylation | SVSIAKDTIERIKII EEEECHHHHHHHHHH | 24.83 | 25882841 | |
| 937 | Phosphorylation | SVSDQKFTDIAGTVR CCCCCCCCCCCCHHH | 33.27 | 22369663 | |
| 942 | Phosphorylation | KFTDIAGTVRASYWY CCCCCCCHHHHHHEE | 9.59 | 22369663 | |
| 946 | Phosphorylation | IAGTVRASYWYNIGI CCCHHHHHHEEEEEH | 12.97 | 22369663 | |
| 947 | Phosphorylation | AGTVRASYWYNIGIS CCHHHHHHEEEEEHH | 15.78 | 22369663 | |
| 949 | Phosphorylation | TVRASYWYNIGISEL HHHHHHEEEEEHHEE | 6.67 | 22369663 | |
| 954 | Phosphorylation | YWYNIGISELTAFIT HEEEEEHHEEEEEEE | 22.72 | 22369663 | |
| 957 | Phosphorylation | NIGISELTAFITLKE EEEHHEEEEEEEECC | 18.57 | 22369663 | |
| 961 | Phosphorylation | SELTAFITLKEPQYR HEEEEEEEECCCCHH | 25.89 | 22369663 | |
| 976 | Ubiquitination | DAAIFAFKKSIQLQS HHHHHHHHHHEECCC | 42.03 | 19722269 | |
| 977 | Ubiquitination | AAIFAFKKSIQLQSN HHHHHHHHHEECCCC | 46.46 | 19722269 | |
| 1088 | Methylation | ILSNGRSKAAQFMYA HHCCCCCHHHHHHHH | 46.51 | 20137074 | |
| 1357 | Ubiquitination | LYRNDTGKQVWQRSA HHCCCCCCCHHHCEE | 43.71 | 23749301 | |
| 1372 | Acetylation | YFFPNNLKVWERLDK EECCCCHHHHHHHHH | 47.64 | 24489116 | |
| 1387 | Phosphorylation | NIQRRIASNGQNKVT HHHHHHHHCCCCCCC | 38.84 | 23749301 | |
| 1392 | Ubiquitination | IASNGQNKVTAEEMS HHHCCCCCCCHHHHH | 32.83 | 23749301 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SKI3_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SKI3_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SKI3_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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