dbPTM

SHC1_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SHC1_YEAST
UniProt AC	P39000
Protein Name	Protein SHC1
Gene Name	SHC1
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	512
Subcellular Localization	Cytoplasm . Cytoplasmic granule membrane Peripheral membrane protein .
Protein Description	Required for the activation of chitin synthase III (CHS3) activity during the sporulation process..
Protein Sequence	MSMTICSNTPGAYPEIGAYNEVDKQLESSGFSSDSSLILNKPEVRQYWSSVSSHISRSGDVFTNDKEKISSSIGEDAMDIDASPSLIEKYNSFPTRKILPEQDEFENDVEDDASSSLKEKSQGSCEIEIASEISSEILNGTSADGNSEFHDFAEPPPSQNESVALSFSQSNDLDFLNNPSGSGSSNDINRSTSSISLPRHVSLDFNVYNSLCLTNEVTASESHNVAKFHLGKKNKKSLLPRWKTIEMYGEVVKKTQDIYSNFQYAQYILRVGLDTEKLHELVKELEDESNSFSVDSLKEYLVNDAKVILKKLSAVGYPDAQYLLGDAYSSGVFGKIKNRRAFLLFSAAAKRMHIESVYRTAICYECGLGVTRNAPKAVNFLTFAATKNHPAAMYKLGVYSYHGLMGLPDDILTKMDGYRWLRRATSMASSFVCGAPFELANIYMTGYKDLIISDPDYAMALYEKAAALGHTESARILEDARRSGGFVSRGHPPSAQKYHKTSHEAVAAKKLI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
502	Phosphorylation	AQKYHKTSHEAVAAK HHHHCCCCHHHHHHH	24.92	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SHC1_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SHC1_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SHC1_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SKT5_YEAST	SKT5	genetic	11918806
UBC4_YEAST	UBC4	genetic	20093466
NHP10_YEAST	NHP10	genetic	20093466
VMA21_YEAST	VMA21	genetic	20093466
YOR1_YEAST	YOR1	genetic	20093466
RT107_YEAST	RTT107	genetic	20093466
YOR1_YEAST	YOR1	genetic	27708008
DAL81_YEAST	DAL81	genetic	27708008
DHOM_YEAST	HOM6	genetic	27708008
SUL2_YEAST	SUL2	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SHC1_YEAST

Related Literatures of Post-Translational Modification