| UniProt ID | DHOM_YEAST | |
|---|---|---|
| UniProt AC | P31116 | |
| Protein Name | Homoserine dehydrogenase | |
| Gene Name | HOM6 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 359 | |
| Subcellular Localization | ||
| Protein Description | ||
| Protein Sequence | MSTKVVNVAVIGAGVVGSAFLDQLLAMKSTITYNLVLLAEAERSLISKDFSPLNVGSDWKAALAASTTKTLPLDDLIAHLKTSPKPVILVDNTSSAYIAGFYTKFVENGISIATPNKKAFSSDLATWKALFSNKPTNGFVYHEATVGAGLPIISFLREIIQTGDEVEKIEGIFSGTLSYIFNEFSTSQANDVKFSDVVKVAKKLGYTEPDPRDDLNGLDVARKVTIVGRISGVEVESPTSFPVQSLIPKPLESVKSADEFLEKLSDYDKDLTQLKKEAATENKVLRFIGKVDVATKSVSVGIEKYDYSHPFASLKGSDNVISIKTKRYTNPVVIQGAGAGAAVTAAGVLGDVIKIAQRL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 33 | Phosphorylation | AMKSTITYNLVLLAE HCCCCHHHHHHHHHH | 11.58 | 29650682 | |
| 48 | Acetylation | AERSLISKDFSPLNV HHHHHHCCCCCCCCC | 56.66 | 24489116 | |
| 51 | Phosphorylation | SLISKDFSPLNVGSD HHHCCCCCCCCCCCH | 38.31 | 21440633 | |
| 57 | Phosphorylation | FSPLNVGSDWKAALA CCCCCCCCHHHHHHH | 35.69 | 21440633 | |
| 60 | Acetylation | LNVGSDWKAALAAST CCCCCHHHHHHHHHC | 28.86 | 24489116 | |
| 60 | Succinylation | LNVGSDWKAALAAST CCCCCHHHHHHHHHC | 28.86 | 23954790 | |
| 69 | Ubiquitination | ALAASTTKTLPLDDL HHHHHCCCEECHHHH | 48.42 | 23749301 | |
| 69 | Acetylation | ALAASTTKTLPLDDL HHHHHCCCEECHHHH | 48.42 | 24489116 | |
| 81 | Acetylation | DDLIAHLKTSPKPVI HHHHHHHCCCCCCEE | 36.77 | 24489116 | |
| 85 | Acetylation | AHLKTSPKPVILVDN HHHCCCCCCEEEECC | 52.24 | 24489116 | |
| 117 | Ubiquitination | ISIATPNKKAFSSDL EEEECCCCCCCCCCH | 46.83 | 23749301 | |
| 117 | Succinylation | ISIATPNKKAFSSDL EEEECCCCCCCCCCH | 46.83 | 23954790 | |
| 118 | Acetylation | SIATPNKKAFSSDLA EEECCCCCCCCCCHH | 62.39 | 24489116 | |
| 118 | Ubiquitination | SIATPNKKAFSSDLA EEECCCCCCCCCCHH | 62.39 | 23749301 | |
| 122 | Phosphorylation | PNKKAFSSDLATWKA CCCCCCCCCHHHHHH | 30.14 | 21440633 | |
| 132 | Phosphorylation | ATWKALFSNKPTNGF HHHHHHHCCCCCCCE | 44.81 | 22369663 | |
| 134 | Acetylation | WKALFSNKPTNGFVY HHHHHCCCCCCCEEE | 52.61 | 24489116 | |
| 136 | Phosphorylation | ALFSNKPTNGFVYHE HHHCCCCCCCEEEEE | 49.97 | 22369663 | |
| 141 | Phosphorylation | KPTNGFVYHEATVGA CCCCCEEEEECCCCC | 7.53 | 22369663 | |
| 145 | Phosphorylation | GFVYHEATVGAGLPI CEEEEECCCCCCCCH | 19.25 | 22369663 | |
| 154 | Phosphorylation | GAGLPIISFLREIIQ CCCCCHHHHHHHHHH | 20.96 | 22369663 | |
| 199 | 2-Hydroxyisobutyrylation | VKFSDVVKVAKKLGY CCHHHHHHHHHHHCC | 36.00 | - | |
| 199 | Acetylation | VKFSDVVKVAKKLGY CCHHHHHHHHHHHCC | 36.00 | 22865919 | |
| 203 | Ubiquitination | DVVKVAKKLGYTEPD HHHHHHHHHCCCCCC | 37.09 | 23749301 | |
| 203 | 2-Hydroxyisobutyrylation | DVVKVAKKLGYTEPD HHHHHHHHHCCCCCC | 37.09 | - | |
| 223 | Ubiquitination | NGLDVARKVTIVGRI CCCCHHCCEEEEEEE | 33.71 | 23749301 | |
| 225 | Phosphorylation | LDVARKVTIVGRISG CCHHCCEEEEEEEEC | 17.00 | 28889911 | |
| 231 | Phosphorylation | VTIVGRISGVEVESP EEEEEEEECCEECCC | 35.11 | 23607784 | |
| 237 | Phosphorylation | ISGVEVESPTSFPVQ EECCEECCCCCCCCH | 38.36 | 22369663 | |
| 239 | Phosphorylation | GVEVESPTSFPVQSL CCEECCCCCCCCHHH | 52.89 | 22369663 | |
| 240 | Phosphorylation | VEVESPTSFPVQSLI CEECCCCCCCCHHHC | 30.82 | 29688323 | |
| 245 | Phosphorylation | PTSFPVQSLIPKPLE CCCCCCHHHCCCCHH | 28.62 | 29688323 | |
| 249 | Acetylation | PVQSLIPKPLESVKS CCHHHCCCCHHHCCC | 56.06 | 24489116 | |
| 253 | Phosphorylation | LIPKPLESVKSADEF HCCCCHHHCCCHHHH | 42.39 | 29688323 | |
| 255 | Succinylation | PKPLESVKSADEFLE CCCHHHCCCHHHHHH | 49.56 | 23954790 | |
| 255 | Acetylation | PKPLESVKSADEFLE CCCHHHCCCHHHHHH | 49.56 | 22865919 | |
| 256 | Phosphorylation | KPLESVKSADEFLEK CCHHHCCCHHHHHHH | 38.50 | 28889911 | |
| 263 | Acetylation | SADEFLEKLSDYDKD CHHHHHHHHHHHCCC | 56.27 | 24489116 | |
| 265 | Phosphorylation | DEFLEKLSDYDKDLT HHHHHHHHHHCCCHH | 45.23 | 22369663 | |
| 267 | Phosphorylation | FLEKLSDYDKDLTQL HHHHHHHHCCCHHHH | 22.86 | 22369663 | |
| 269 | Acetylation | EKLSDYDKDLTQLKK HHHHHHCCCHHHHHH | 48.70 | 24489116 | |
| 269 | 2-Hydroxyisobutyrylation | EKLSDYDKDLTQLKK HHHHHHCCCHHHHHH | 48.70 | - | |
| 275 | Acetylation | DKDLTQLKKEAATEN CCCHHHHHHHHHHHC | 38.46 | 24489116 | |
| 275 | 2-Hydroxyisobutyrylation | DKDLTQLKKEAATEN CCCHHHHHHHHHHHC | 38.46 | - | |
| 283 | Ubiquitination | KEAATENKVLRFIGK HHHHHHCCHHHHHCC | 36.09 | 23749301 | |
| 283 | Acetylation | KEAATENKVLRFIGK HHHHHHCCHHHHHCC | 36.09 | 22865919 | |
| 290 | Succinylation | KVLRFIGKVDVATKS CHHHHHCCCEEECCE | 30.37 | 23954790 | |
| 290 | Ubiquitination | KVLRFIGKVDVATKS CHHHHHCCCEEECCE | 30.37 | 23749301 | |
| 296 | 2-Hydroxyisobutyrylation | GKVDVATKSVSVGIE CCCEEECCEEEEEEE | 38.84 | - | |
| 296 | Ubiquitination | GKVDVATKSVSVGIE CCCEEECCEEEEEEE | 38.84 | 23749301 | |
| 297 | Phosphorylation | KVDVATKSVSVGIEK CCEEECCEEEEEEEE | 18.44 | 22369663 | |
| 299 | Phosphorylation | DVATKSVSVGIEKYD EEECCEEEEEEEECC | 23.01 | 22369663 | |
| 304 | Acetylation | SVSVGIEKYDYSHPF EEEEEEEECCCCCCC | 41.31 | 24489116 | |
| 304 | Ubiquitination | SVSVGIEKYDYSHPF EEEEEEEECCCCCCC | 41.31 | 23749301 | |
| 307 | Phosphorylation | VGIEKYDYSHPFASL EEEEECCCCCCCHHC | 13.04 | 28889911 | |
| 313 | Phosphorylation | DYSHPFASLKGSDNV CCCCCCHHCCCCCCE | 30.87 | 28889911 | |
| 315 | Acetylation | SHPFASLKGSDNVIS CCCCHHCCCCCCEEE | 54.60 | 22865919 | |
| 324 | Ubiquitination | SDNVISIKTKRYTNP CCCEEEEEECEECCC | 41.00 | 23749301 | |
| 326 | Ubiquitination | NVISIKTKRYTNPVV CEEEEEECEECCCEE | 38.10 | 22817900 | |
| 328 | Phosphorylation | ISIKTKRYTNPVVIQ EEEEECEECCCEEEE | 16.66 | 21440633 | |
| 329 | Phosphorylation | SIKTKRYTNPVVIQG EEEECEECCCEEEEC | 36.76 | 22369663 | |
| 344 | Phosphorylation | AGAGAAVTAAGVLGD CCHHHHHHHHHHHHH | 13.18 | 22369663 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DHOM_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DHOM_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DHOM_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND THR-344, ANDMASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-237 AND THR-239, ANDMASS SPECTROMETRY. | |
