ADH3_YEAST - dbPTM
ADH3_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADH3_YEAST
UniProt AC P07246
Protein Name Alcohol dehydrogenase 3, mitochondrial
Gene Name ADH3
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 375
Subcellular Localization Mitochondrion matrix.
Protein Description
Protein Sequence MLRTSTLFTRRVQPSLFSRNILRLQSTAAIPKTQKGVIFYENKGKLHYKDIPVPEPKPNEILINVKYSGVCHTDLHAWHGDWPLPVKLPLVGGHEGAGVVVKLGSNVKGWKVGDLAGIKWLNGSCMTCEFCESGHESNCPDADLSGYTHDGSFQQFATADAIQAAKIQQGTDLAEVAPILCAGVTVYKALKEADLKAGDWVAISGAAGGLGSLAVQYATAMGYRVLGIDAGEEKEKLFKKLGGEVFIDFTKTKNMVSDIQEATKGGPHGVINVSVSEAAISLSTEYVRPCGTVVLVGLPANAYVKSEVFSHVVKSINIKGSYVGNRADTREALDFFSRGLIKSPIKIVGLSELPKVYDLMEKGKILGRYVVDTSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
43AcetylationGVIFYENKGKLHYKD
EEEEEEECCEEEEEE		45.5424489116
49SuccinylationNKGKLHYKDIPVPEP
ECCEEEEEECCCCCC		38.1323954790
49AcetylationNKGKLHYKDIPVPEP
ECCEEEEEECCCCCC		38.1324489116
57AcetylationDIPVPEPKPNEILIN
ECCCCCCCCCCEEEE		59.8324489116
73PhosphorylationKYSGVCHTDLHAWHG
EECCCCCCCHHHCCC		34.8221440633
111AcetylationGSNVKGWKVGDLAGI
CCCCCCEECCHHCCC		45.0424489116
234AcetylationGIDAGEEKEKLFKKL
CCCCCHHHHHHHHHH		56.7124489116
236AcetylationDAGEEKEKLFKKLGG
CCCHHHHHHHHHHCC		71.0024489116
2362-HydroxyisobutyrylationDAGEEKEKLFKKLGG
CCCHHHHHHHHHHCC		71.00-
310PhosphorylationYVKSEVFSHVVKSIN
CCCHHHHHHHHHHCC		22.1328889911
319SuccinylationVVKSINIKGSYVGNR
HHHHCCCCCCCCCCC		37.0023954790
3192-HydroxyisobutyrylationVVKSINIKGSYVGNR
HHHHCCCCCCCCCCC		37.00-
329PhosphorylationYVGNRADTREALDFF
CCCCCCCHHHHHHHH		29.4428889911
342UbiquitinationFFSRGLIKSPIKIVG
HHHHCCCCCCEEEEE		56.0423749301
343PhosphorylationFSRGLIKSPIKIVGL
HHHCCCCCCEEEEEH		25.5129136822
346AcetylationGLIKSPIKIVGLSEL
CCCCCCEEEEEHHHC		34.4224489116
355AcetylationVGLSELPKVYDLMEK
EEHHHCCCHHHHHHH		67.0824489116
362AcetylationKVYDLMEKGKILGRY
CHHHHHHHCCEEEEE		52.0924489116
362UbiquitinationKVYDLMEKGKILGRY
CHHHHHHHCCEEEEE		52.0923749301
375UbiquitinationRYVVDTSK-------
EEEEECCC-------		67.4617644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADH3_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADH3_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADH3_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NDI1_YEASTNDI1genetic
10940011
TPS1_YEASTTPS1genetic
20093466
BUD31_YEASTBUD31genetic
20093466
PDP2_YEASTPTC6genetic
20093466
UBC13_YEASTUBC13genetic
20093466
RMD5_YEASTRMD5genetic
20093466
ARO8_YEASTARO8genetic
20093466
GCN1_YEASTGCN1genetic
20093466
HUR1_YEASTHUR1genetic
20093466
PEX14_YEASTPEX14genetic
20093466
PEX8_YEASTPEX8genetic
20093466
UBCX_YEASTPEX4genetic
20093466
SPO11_YEASTSPO11genetic
20093466
FYV10_YEASTFYV10genetic
20093466
PEX1_YEASTPEX1genetic
20093466
PEX13_YEASTPEX13genetic
20093466
PFD6_YEASTYKE2genetic
20093466
NDI1_YEASTNDI1genetic
20093466
COX7_YEASTCOX7genetic
20093466
YO029_YEASTYOL029Cgenetic
20093466
MDM38_YEASTMDM38genetic
20093466
IES4_YEASTIES4genetic
20093466
MRS2_YEASTMRS2genetic
20093466
ATG29_YEASTATG29genetic
20093466
UME1_YEASTUME1genetic
20093466
ISU1_YEASTISU1genetic
20093466
MEI5_YEASTMEI5genetic
20093466
OAZ_YEASTOAZ1genetic
20093466
ADH4_YEASTADH4genetic
22033067
ADH5_YEASTADH5genetic
22033067
FADH_YEASTSFA1genetic
22033067
ADH3_YEASTADH3physical
22940862
KRE9_YEASTKRE9genetic
27708008
CDC3_YEASTCDC3genetic
27708008
TPS1_YEASTTPS1genetic
27708008
BUD31_YEASTBUD31genetic
27708008
PAT1_YEASTPAT1genetic
27708008
PDP2_YEASTPTC6genetic
27708008
TPS2_YEASTTPS2genetic
27708008
MIC19_YEASTMIC19genetic
27708008
HXKB_YEASTHXK2genetic
27708008
SET2_YEASTSET2genetic
27708008
UME1_YEASTUME1genetic
27708008
RMRP_YEASTSNM1genetic
27708008
MET30_YEASTMET30genetic
27708008
TIM14_YEASTPAM18genetic
27708008
RPC6_YEASTRPC34genetic
27708008
GID4_YEASTVID24genetic
27708008
UBC13_YEASTUBC13genetic
27708008
HUR1_YEASTHUR1genetic
27708008
GCN1_YEASTGCN1genetic
27708008
ARO8_YEASTARO8genetic
27708008
PEX8_YEASTPEX8genetic
27708008
PFD3_YEASTPAC10genetic
27708008
UBCX_YEASTPEX4genetic
27708008
SPO11_YEASTSPO11genetic
27708008
MED20_YEASTSRB2genetic
27708008
FYV10_YEASTFYV10genetic
27708008
PEX2_YEASTPEX2genetic
27708008
PEX1_YEASTPEX1genetic
27708008
PEX13_YEASTPEX13genetic
27708008
PFD6_YEASTYKE2genetic
27708008
NDI1_YEASTNDI1genetic
27708008
COX7_YEASTCOX7genetic
27708008
SWS2_YEASTSWS2genetic
27708008
MDM38_YEASTMDM38genetic
27708008
ASE1_YEASTASE1genetic
27708008
MRS2_YEASTMRS2genetic
27708008
OAZ_YEASTOAZ1genetic
27708008
LPE10_YEASTMFM1genetic
27708008
ISU1_YEASTISU1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADH3_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-310, AND MASSSPECTROMETRY.

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