ADH5_YEAST - dbPTM
ADH5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ADH5_YEAST
UniProt AC P38113
Protein Name Alcohol dehydrogenase 5
Gene Name ADH5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 351
Subcellular Localization
Protein Description
Protein Sequence MPSQVIPEKQKAIVFYETDGKLEYKDVTVPEPKPNEILVHVKYSGVCHSDLHAWHGDWPFQLKFPLIGGHEGAGVVVKLGSNVKGWKVGDFAGIKWLNGTCMSCEYCEVGNESQCPYLDGTGFTHDGTFQEYATADAVQAAHIPPNVNLAEVAPILCAGITVYKALKRANVIPGQWVTISGACGGLGSLAIQYALAMGYRVIGIDGGNAKRKLFEQLGGEIFIDFTEEKDIVGAIIKATNGGSHGVINVSVSEAAIEASTRYCRPNGTVVLVGMPAHAYCNSDVFNQVVKSISIVGSCVGNRADTREALDFFARGLIKSPIHLAGLSDVPEIFAKMEKGEIVGRYVVETSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MPSQVIPEKQ
-----CCCCCCCCCC		35.4622369663
226PhosphorylationGEIFIDFTEEKDIVG
CEEEEECCCCCCEEE		39.21-
252PhosphorylationGVINVSVSEAAIEAS
CEEEEEHHHHHHHHH		17.6328889911
282PhosphorylationPAHAYCNSDVFNQVV
CCCEECCHHHHHHHH		31.43-
290UbiquitinationDVFNQVVKSISIVGS
HHHHHHHHHHEEEEC		43.1222817900
305PhosphorylationCVGNRADTREALDFF
CCCCCCCHHHHHHHH		29.4417563356
318UbiquitinationFFARGLIKSPIHLAG
HHHHHHHCCCHHHCC		56.0417644757
319PhosphorylationFARGLIKSPIHLAGL
HHHHHHCCCHHHCCC		23.30-
335UbiquitinationDVPEIFAKMEKGEIV
CHHHHHHHHHCCCEE		36.5217644757
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ADH5_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ADH5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ADH5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
FABD_YEASTMCT1genetic
21623372
FADH_YEASTSFA1genetic
22033067
TFS2_YEASTDST1genetic
27708008
RL8A_YEASTRPL8Agenetic
27708008
BFA1_YEASTBFA1genetic
27708008
PUR91_YEASTADE16genetic
27708008
UPS1_YEASTUPS1genetic
27708008
PET8_YEASTPET8genetic
27708008
MKT1_YEASTMKT1genetic
27708008
GGPPS_YEASTBTS1genetic
27708008
CDC1_YEASTCDC1genetic
27708008
COG3_YEASTCOG3genetic
27708008
ACT_YEASTACT1genetic
27708008
PP2C3_YEASTPTC3genetic
27708008
VAM6_YEASTVAM6genetic
27708008
TPS2_YEASTTPS2genetic
27708008
RLA4_YEASTRPP2Bgenetic
27708008
SAC7_YEASTSAC7genetic
27708008
SWI4_YEASTSWI4genetic
27708008
XRN1_YEASTXRN1genetic
27708008
ADH4_YEASTADH4genetic
27708008
TNA1_YEASTTNA1genetic
27708008
IRE1_YEASTIRE1genetic
27708008
KC11_YEASTYCK1genetic
27708008
MPH1_YEASTMPH1genetic
27708008
HOC1_YEASTHOC1genetic
27708008
BCA2_YEASTBAT2genetic
27708008
CAPZA_YEASTCAP1genetic
27708008
LHS1_YEASTLHS1genetic
27708008
CWP2_YEASTCWP2genetic
27708008
OMA1_YEASTOMA1genetic
27708008
SPA2_YEASTSPA2genetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
EFM7_YEASTNNT1genetic
27708008
BUD8_YEASTBUD8genetic
27708008
ROM2_YEASTROM2genetic
27708008
VID22_YEASTVID22genetic
27708008
AIM36_YEASTAIM36genetic
27708008
RM44_YEASTMRPL44genetic
27708008
TDA1_YEASTTDA1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
BECN1_YEASTVPS30genetic
27708008
PTPA2_YEASTRRD2genetic
27708008
CGS5_YEASTCLB5genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ADH5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-252 AND THR-305, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-305, AND MASSSPECTROMETRY.

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