EFM7_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EFM7_YEAST
• UniProt AC: Q05874
• Protein Name: Protein N-terminal and lysine N-methyltransferase EFM7 {ECO:0000255|HAMAP-Rule:MF_03223, ECO:0000305|PubMed:26545399}
• Gene Name: NNT1 {ECO:0000303|PubMed:12736687}
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 261
• Subcellular Localization: Cytoplasm .
• Protein Description: S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha (TEF1 and TEF2), before also catalyzing the mono- and dimethylation of 'Lys-3'. [PubMed: 21858014]
• Protein Sequence: MSDIESLGEAAGLFEEPEDFLPPPPKPHFAEYQRSHITKESKSDVKDIKLRLVGTSPLWGHLLWNAGIYTANHLDSHPELIKGKTVLELGAAAALPSVICALNGAQMVVSTDYPDPDLMQNIDYNIKSNVPEDFNNVSTEGYIWGNDYSPLLAHIEKIGNNNGKFDLIILSDLVFNHTEHHKLLQTTKDLLAEKGQALVVFSPHRPKLLEKDLEFFELAKNEFHLVPQLIEMVNWKPMFDEDEETIEVRSRVYAYYLTHEK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSDIESLGE ------CCHHHHHHH		22369663
6	Phosphorylation	--MSDIESLGEAAGL --CCHHHHHHHHCCC		22369663
32	Phosphorylation	PKPHFAEYQRSHITK CCCCHHHHHHHHCCC		19823750
35	Phosphorylation	HFAEYQRSHITKESK CHHHHHHHHCCCCCH		19823750
38	Phosphorylation	EYQRSHITKESKSDV HHHHHHCCCCCHHHH		19823750
188	Ubiquitination	HKLLQTTKDLLAEKG HHHHHHHHHHHHHCC		24961812
188	Acetylation	HKLLQTTKDLLAEKG HHHHHHHHHHHHHCC		24489116
207	Acetylation	VFSPHRPKLLEKDLE EECCCCCHHHHHHHH		24489116
211	Acetylation	HRPKLLEKDLEFFEL CCCHHHHHHHHHHHH		24489116

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EFM7_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EFM7_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EFM7_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3G_YEAST	TIF35	genetic	19061648
CAK1_YEAST	CAK1	genetic	19061648
NUP59_YEAST	ASM4	genetic	19061648
CDC48_YEAST	CDC48	physical	23349634
IF2P_YEAST	FUN12	physical	23349634
MPM1_YEAST	MPM1	physical	23349634
EFM7_YEAST	NNT1	physical	23349634
PGK_YEAST	PGK1	physical	23349634
PMM_YEAST	SEC53	physical	23349634
SRO7_YEAST	SRO7	genetic	27708008
REI1_YEAST	REI1	genetic	27708008
SNF6_YEAST	SNF6	genetic	27708008
EFM6_YEAST	YNL024C	genetic	27708008
LIPA_YEAST	LIP5	genetic	27708008

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.