CAK1_YEAST - dbPTM
CAK1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CAK1_YEAST
UniProt AC P43568
Protein Name Serine/threonine-protein kinase CAK1
Gene Name CAK1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 368
Subcellular Localization
Protein Description
Protein Sequence MKLDSIDITHCQLVKSTRTARIYRSDTYAIKCLALDFDIPPHNAKFEVSILNKLGNKCKHILPLLESKATDNNDLLLLFPFEEMNLYEFMQMHYKRDRRKKNPYYDLLNPSIPIVADPPVQKYTNQLDVNRYSLSFFRQMVEGIAFLHENKIIHRDIKPQNIMLTNNTSTVSPKLYIIDFGISYDMANNSQTSAEPMDSKVTDISTGIYKAPEVLFGVKCYDGGVDVWSLLIIISQWFQRETSRMGHVPAMIDDGSDDMNSDGSDFRLICSIFEKLGIPSIQKWEEVAQHGSVDAFVGMFGADGDGKYVLDQEKDVQISIVERNMPRLDEIADVKVKQKFINCILGMVSFSPNERWSCQRILQELEKP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
205PhosphorylationDSKVTDISTGIYKAP
CCCCEECCCCCCCCC		24.3228889911
261PhosphorylationDGSDDMNSDGSDFRL
CCCCCCCCCCCHHHH		36.3928889911
351PhosphorylationILGMVSFSPNERWSC
HHHCCCCCCCCHHHH		21.2225752575
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CAK1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CAK1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CAK1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CDK1_YEASTCDC28physical
8752211
CDK1_YEASTCDC28physical
10793138
KIN28_YEASTKIN28physical
10373527
KIN28_YEASTKIN28physical
9774652
CDK1_YEASTCDC28physical
9393434
CDK1_YEASTCDC28physical
8752210
CTK1_YEASTCTK1physical
15870265
PTP2_YEASTPTP2genetic
10580002
PTP3_YEASTPTP3genetic
10580002
CG22_YEASTCLB2genetic
8752210
IME2_YEASTIME2genetic
14612412
KIN28_YEASTKIN28genetic
9774652
CDK1_YEASTCDC28genetic
11527976
CDK1_YEASTCDC28genetic
9566911
KIN28_YEASTKIN28genetic
16362371
GPI1_YEASTGPI1genetic
16362371
MAS5_YEASTYDJ1genetic
16362371
PAF1_YEASTPAF1genetic
16362371
CTR9_YEASTCTR9genetic
16362371
SSU72_YEASTSSU72genetic
16362371
CLA4_YEASTCLA4genetic
18373684
CDK1_YEASTCDC28genetic
18373684
UBI4P_YEASTUBI4genetic
19061648
KA122_YEASTKAP122genetic
19061648
PML39_YEASTPML39genetic
19061648
ELP3_YEASTELP3genetic
19061648
RIC1_YEASTRIC1genetic
19061648
SLS1_YEASTSLS1genetic
19061648
UPF3_YEASTUPF3genetic
19061648
PSA3_YEASTPRE9genetic
19061648
CSN12_YEASTYJR084Wgenetic
19061648
PAN3_YEASTPAN3genetic
19061648
IF2M_YEASTIFM1genetic
19061648
NAM7_YEASTNAM7genetic
19061648
SUV3_YEASTSUV3genetic
19061648
EAF3_YEASTEAF3genetic
19061648
SLT2_YEASTSLT2genetic
19269370
SWD1_YEASTSWD1genetic
19269370
TPS1_YEASTTPS1genetic
19269370
KCC4_YEASTKCC4genetic
19269370
STE50_YEASTSTE50genetic
19269370
MRC1_YEASTMRC1genetic
19269370
RPA14_YEASTRPA14genetic
19269370
IPK1_YEASTIPK1genetic
19269370
VPS72_YEASTVPS72genetic
19269370
RAD51_YEASTRAD51genetic
19269370
CSK2B_YEASTCKB1genetic
19269370
SKI8_YEASTSKI8genetic
19269370
SAP4_YEASTSAP4genetic
19269370
CTF8_YEASTCTF8genetic
19269370
CTK2_YEASTCTK2genetic
19269370
SET2_YEASTSET2genetic
19269370
ADK_YEASTADO1genetic
19269370
SIC1_YEASTSIC1genetic
19269370
SEC22_YEASTSEC22genetic
19269370
PFD5_YEASTGIM5genetic
19269370
CTK3_YEASTCTK3genetic
19269370
TBA3_YEASTTUB3genetic
19269370
INP52_YEASTINP52genetic
19269370
PFD4_YEASTGIM3genetic
19269370
H2AZ_YEASTHTZ1genetic
19269370
PSK2_YEASTPSK2genetic
19269370
6P22_YEASTPFK27genetic
19269370
CTI6_YEASTCTI6genetic
19269370
TBCC_YEASTCIN2genetic
19269370
EAF3_YEASTEAF3genetic
19269370
MCM16_YEASTMCM16genetic
19269370
CDK1_YEASTCDC28genetic
18716324
CDK1_YEASTCDC28genetic
9774652
CDK1_YEASTCDC28physical
20489023
TWF1_YEASTTWF1physical
20489023
AIM3_YEASTAIM3genetic
21035341
CDC13_YEASTCDC13physical
21460040
DRS1_YEASTDRS1physical
21460040
PCNA_YEASTPOL30physical
21460040
CDK1_YEASTCDC28genetic
10747052
SMK1_YEASTSMK1physical
23207907
CDK2_HUMANCDK2physical
25691663
CDK1_SCHPOcdc2physical
25691663
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CAK1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205, AND MASSSPECTROMETRY.

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