TWF1_YEAST - dbPTM
TWF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TWF1_YEAST
UniProt AC P53250
Protein Name Twinfilin-1
Gene Name TWF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 332
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. Prevents actin filament assembly by forming a 1:1 complex with actin monomers, and inhibits the nucleotide exchange reaction of actin monomers (By similarity)..
Protein Sequence MSTQSGIVAEQALLHSLNENLSADGIVIIIAKISPDSTSVHQTQVARSFEELVQLASQEREPLYIFYKPEGLDKYFFVSFIPDGSPVRSRMLYASTKNTLARQVGSNSLSTEQPLITDAQDLVDLKNFDSARPAGQNKPLTHDEEMQIEINKQQALLRKNTSVKLVSQDSASPLSLTFRVNSEKPINEILDSEGKNLIIFQIDPSNETIQIVQSDTCPSVDELYIDLPGPSYTIFRQGDSSFFIYSCPSGSKVKDRMIYASNKNGFINYLKNDQKIAFSKVVEIGDFVELDKSLLMATNKEDSLDHGSNPDLPNKSNLKFNKPKGPLRKRRT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
161PhosphorylationQALLRKNTSVKLVSQ
HHHHHCCCEEEEEEC		37.6220377248
162PhosphorylationALLRKNTSVKLVSQD
HHHHCCCEEEEEECC		27.0121440633
164AcetylationLRKNTSVKLVSQDSA
HHCCCEEEEEECCCC		42.8325381059
167PhosphorylationNTSVKLVSQDSASPL
CCEEEEEECCCCCCC		38.4129136822
170PhosphorylationVKLVSQDSASPLSLT
EEEEECCCCCCCEEE		24.0229136822
172PhosphorylationLVSQDSASPLSLTFR
EEECCCCCCCEEEEE		30.2621082442
175PhosphorylationQDSASPLSLTFRVNS
CCCCCCCEEEEEECC		28.8424961812
271AcetylationNGFINYLKNDQKIAF
CCCCHHCCCCCEEEE		48.3924489116
293PhosphorylationDFVELDKSLLMATNK
CCEECCHHHHHHCCC		26.8026447709
298PhosphorylationDKSLLMATNKEDSLD
CHHHHHHCCCCCCCC		32.6226447709
300AcetylationSLLMATNKEDSLDHG
HHHHHCCCCCCCCCC		59.5524489116
303PhosphorylationMATNKEDSLDHGSNP
HHCCCCCCCCCCCCC		36.4722369663
308PhosphorylationEDSLDHGSNPDLPNK
CCCCCCCCCCCCCCC		41.5922369663
319AcetylationLPNKSNLKFNKPKGP
CCCCCCCCCCCCCCC		51.6625381059
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TWF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TWF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TWF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ACT_YEASTACT1physical
11604420
CAPZB_YEASTCAP2physical
11604420
CAPZA_YEASTCAP1physical
11604420
COFI_YEASTCOF1genetic
9700161
ACT_YEASTACT1physical
16569665
CAP_YEASTSRV2physical
18467557
TWF1_YEASTTWF1physical
18467557
ART5_YEASTART5physical
20489023
BEM2_YEASTBEM2physical
20489023
NOP15_YEASTNOP15physical
20489023
CAP_YEASTSRV2physical
20489023
PP2C1_YEASTPTC1genetic
21127252
SWI4_YEASTSWI4genetic
21127252
RMRP_YEASTSNM1genetic
27708008
SED5_YEASTSED5genetic
27708008
MCM1_YEASTMCM1genetic
27708008
MAK16_YEASTMAK16genetic
27708008
CDC24_YEASTCDC24genetic
27708008
GPI18_YEASTGPI18genetic
27708008
APC11_YEASTAPC11genetic
27708008
CDC7_YEASTCDC7genetic
27708008
SNU56_YEASTSNU56genetic
27708008
GPI11_YEASTGPI11genetic
27708008
RSP5_YEASTRSP5genetic
27708008
ACT_YEASTACT1genetic
27708008
PSA1_YEASTSCL1genetic
27708008
STT3_YEASTSTT3genetic
27708008
PRI1_YEASTPRI1genetic
27708008
NU192_YEASTNUP192genetic
27708008
RFC2_YEASTRFC2genetic
27708008
CDC11_YEASTCDC11genetic
27708008
COFI_YEASTCOF1genetic
27708008
TIM14_YEASTPAM18genetic
27708008
CD123_YEASTCDC123genetic
27708008
ARP9_YEASTARP9genetic
27708008
ERB1_YEASTERB1genetic
27708008
GPI12_YEASTGPI12genetic
27708008
DPOA_YEASTPOL1genetic
27708008
CAP_YEASTSRV2genetic
27708008
ARPC2_YEASTARC35genetic
27708008
PROF_YEASTPFY1genetic
27708008
SEC63_YEASTSEC63genetic
27708008
ORC4_YEASTORC4genetic
27708008
ACT_YEASTACT1physical
26458246
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TWF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167 AND SER-172, ANDMASS SPECTROMETRY.

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