ART5_YEAST - dbPTM
ART5_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ART5_YEAST
UniProt AC P53244
Protein Name Arrestin-related trafficking adapter 5
Gene Name ART5
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 586
Subcellular Localization
Protein Description May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli..
Protein Sequence MFSLSSLSSSGGHSEQKERERISYFDIRINSPYKDIILIQGSPLELSSIPLSGNLVISVKNEIVVKKISLRLVGRFKLEFLQVGRYKKNSSSLASLVKEKRKIFECYWDNLLVSSKGDVLVGGENAENQHNSSSGRSTSNQDMDTSGNAIFLSKRSLSSPVFNKIIRRKTHSSHRKILELPENGVTGTPFEGLRENARSRSSSSNTLNNNSHSYSNRDGSGSSYLFLMKRGNYELPFNTMLPPEVCETIEGLQSGSILYSFEAIIDGRQLWDTDLSVHTSPHGPIGSTSTSGNGMRTKNKIIIKKFKYLRILRTLSMDNLAMQEEISVGNTWRDKLQYETSIPSRAVPIGSTTPVKIKIFPFEKNIRLDRIEMALIQYYAMKDSSAQIYDDEIAVMKITHLADFGPLTDKLDVDCPFTIPDNLKQITQDCCLQDNLIRVMHKLQVRILLQRQVDGEYKNLEIKAQLPMLLFISPHLPMKGRLVLFDKHDGKIHFRPGELVPLFLTTYPAQGLTPGVELNSTTTAHLALPQPPPNYHESTNDHLMPALQPLGADSVVLTVPSYEQAQAQASASSYVTGSVPAYCDDD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17UbiquitinationSGGHSEQKERERISY
CCCCCCHHHHHCCCE		55.4724961812
90PhosphorylationVGRYKKNSSSLASLV
ECCCCCCCCHHHHHH		30.1321126336
137PhosphorylationHNSSSGRSTSNQDMD
CCCCCCCCCCCCCCC		39.4527017623
138PhosphorylationNSSSGRSTSNQDMDT
CCCCCCCCCCCCCCC		30.2719779198
154UbiquitinationGNAIFLSKRSLSSPV
CCEEEEECCCCCCHH		48.4223749301
156PhosphorylationAIFLSKRSLSSPVFN
EEEEECCCCCCHHHH		36.0228889911
158PhosphorylationFLSKRSLSSPVFNKI
EEECCCCCCHHHHHH		33.5722369663
159PhosphorylationLSKRSLSSPVFNKII
EECCCCCCHHHHHHH		30.3121440633
164UbiquitinationLSSPVFNKIIRRKTH
CCCHHHHHHHHHCCC		28.2224961812
201PhosphorylationRENARSRSSSSNTLN
HHHHHHCCCCCCCCC		35.5023749301
202PhosphorylationENARSRSSSSNTLNN
HHHHHCCCCCCCCCC		36.3522369663
203PhosphorylationNARSRSSSSNTLNNN
HHHHCCCCCCCCCCC		28.9322369663
204PhosphorylationARSRSSSSNTLNNNS
HHHCCCCCCCCCCCC		35.4622369663
206PhosphorylationSRSSSSNTLNNNSHS
HCCCCCCCCCCCCCC		32.5823749301
211PhosphorylationSNTLNNNSHSYSNRD
CCCCCCCCCCCCCCC		18.8822369663
213PhosphorylationTLNNNSHSYSNRDGS
CCCCCCCCCCCCCCC		30.0322369663
364UbiquitinationIKIFPFEKNIRLDRI
EEEEECCCCCCHHHH		59.0423749301
473PhosphorylationLPMLLFISPHLPMKG
CCEEEEECCCCCCCC		10.0327017623
487AcetylationGRLVLFDKHDGKIHF
CEEEEEECCCCEEEE		35.9424489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseRSP5P39940
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ART5_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ART5_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CSK2B_YEASTCKB1physical
10688190
SFT2_YEASTSFT2physical
10688190
RRP1_YEASTRRP1physical
16554755
LYS12_YEASTLYS12physical
16554755
TAM41_YEASTTAM41genetic
23623749
HIR1_YEASTHIR1genetic
27708008
SHG1_YEASTSHG1genetic
27708008
ARX1_YEASTARX1genetic
27708008
DGK1_YEASTDGK1genetic
27708008
SRO7_YEASTSRO7genetic
27708008
GPI11_YEASTGPI11genetic
27708008
SEC20_YEASTSEC20genetic
27708008
PRP21_YEASTPRP21genetic
27708008
SED5_YEASTSED5genetic
27708008
BOS1_YEASTBOS1genetic
27708008
SEC65_YEASTSEC65genetic
27708008
SMC5_YEASTSMC5genetic
27708008
PGTB2_YEASTBET2genetic
27708008
NTH1_YEASTNTG1genetic
27708008
GPT1_YEASTSCT1genetic
27708008
IML3_YEASTIML3genetic
27708008
MTC4_YEASTMTC4genetic
27708008
SNF5_YEASTSNF5genetic
27708008
VAM6_YEASTVAM6genetic
27708008
BAP3_YEASTBAP3genetic
27708008
NUM1_YEASTNUM1genetic
27708008
ACL4_YEASTYDR161Wgenetic
27708008
OPI1_YEASTOPI1genetic
27708008
RS27B_YEASTRPS27Bgenetic
27708008
HTD2_YEASTHTD2genetic
27708008
ACA2_YEASTCST6genetic
27708008
ATG32_YEASTATG32genetic
27708008
NCA3_YEASTNCA3genetic
27708008
ILM1_YEASTILM1genetic
27708008
YJ9K_YEASTYJR146Wgenetic
27708008
YL032_YEASTYLL032Cgenetic
27708008
SIC1_YEASTSIC1genetic
27708008
ENT2_YEASTENT2genetic
27708008
EFM7_YEASTNNT1genetic
27708008
PFKA2_YEASTPFK2genetic
27708008
PHO23_YEASTPHO23genetic
27708008
CYB5_YEASTCYB5genetic
27708008
HUB1_YEASTHUB1genetic
27708008
SIN3_YEASTSIN3genetic
27708008
TIR4_YEASTTIR4genetic
27708008
HAT1_YEASTHAT1genetic
27708008
MGR2_YEASTMGR2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ART5_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158 AND SER-203, ANDMASS SPECTROMETRY.
"Quantitative phosphoproteomics applied to the yeast pheromonesignaling pathway.";
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J.,Mann M., Jensen O.N.;
Mol. Cell. Proteomics 4:310-327(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-158, AND MASSSPECTROMETRY.

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