| UniProt ID | SRO7_YEAST | |
|---|---|---|
| UniProt AC | Q12038 | |
| Protein Name | Lethal(2) giant larvae protein homolog SRO7 | |
| Gene Name | SRO7 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 1033 | |
| Subcellular Localization |
Cytoplasm . Cell membrane Peripheral membrane protein Cytoplasmic side . |
|
| Protein Description | Acts as an allosteric regulator of polarized exocytosis by promoting the targeted fusion of vesicles with the plasma membrane. Coordinates the spatial and temporal nature of both Rab-dependent tethering and SNARE-dependent membrane fusion of exocytic vesicles with the plasma membrane. Required for targeting of the sodium pumping ATPase ENA1 to the Cell Surface, thus being involved in maintenance of ion homeostasis in cells exposed to NaCl stress. May be involved in the targeting of the myosin proteins to their intrinsic pathways. Multicopy suppressor of RHO3. May also participate in the maintenance of cell polarity and bud growth.. | |
| Protein Sequence | MFGSKRLKNVKEAFKSLKGQNSETPIENSKASFKSKNSKTSTISKDAKSSSSLKIPISSNNKNKIFSLAETNKYGMSSKPIAAAFDFTQNLLAIATVTGEVHIYGQQQVEVVIKLEDRSAIKEMRFVKGIYLVVINAKDTVYVLSLYSQKVLTTVFVPGKITSIDTDASLDWMLIGLQNGSMIVYDIDRDQLSSFKLDNLQKSSFFPAARLSPIVSIQWNPRDIGTVLISYEYVTLTYSLVENEIKQSFIYELPPFAPGGDFSEKTNEKRTPKVIQSLYHPNSLHIITIHEDNSLVFWDANSGHMIMARTVFETEINVPQPDYIRDSSTNAAKISKVYWMCENNPEYTSLLISHKSISRGDNQSLTMIDLGYTPRYSITSYEGMKNYYANPKQMKIFPLPTNVPIVNILPIPRQSPYFAGCHNPGLILLILGNGEIETMLYPSGIFTDKASLFPQNLSWLRPLATTSMAASVPNKLWLGALSAAQNKDYLLKGGVRTKRQKLPAEYGTAFITGHSNGSVRIYDASHGDIQDNASFEVNLSRTLNKAKELAVDKISFAAETLELAVSIETGDVVLFKYEVNQFYSVENRPESGDLEMNFRRFSLNNTNGVLVDVRDRAPTGVRQGFMPSTAVHANKGKTSAINNSNIGFVGIAYAAGSLMLIDRRGPAIIYMENIREISGAQSACVTCIEFVIMEYGDDGYSSILMVCGTDMGEVITYKILPASGGKFDVQLMDITNVTSKGPIHKIDAFSKETKSSCLATIPKMQNLSKGLCIPGIVLITGFDDIRLITLGKSKSTHKGFKYPLAATGLSYISTVEKNNDRKNLTVIITLEINGHLRVFTIPDFKEQMSEHIPFPIAAKYITESSVLRNGDIAIRVSEFQASLFSTVKEQDTLAPVSDTLYINGIRIPYRPQVNSLQWARGTVYCTPAQLNELLGGVNRPASKYKESIIAEGSFSERSSDDNNANHPEHQYTKPTRKGRNSSYGVLRNVSRAVETRWDAVEDRFNDYATAMGETMNEAVEQTGKDVMKGALGF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Acetylation | KNVKEAFKSLKGQNS HHHHHHHHHCCCCCC | 63.02 | 25381059 | |
| 22 | Phosphorylation | KSLKGQNSETPIENS HHCCCCCCCCCCCCC | 34.65 | 30377154 | |
| 29 | Phosphorylation | SETPIENSKASFKSK CCCCCCCCCHHHCCC | 19.46 | 21440633 | |
| 32 | Phosphorylation | PIENSKASFKSKNSK CCCCCCHHHCCCCCC | 36.62 | 21440633 | |
| 35 | Phosphorylation | NSKASFKSKNSKTST CCCHHHCCCCCCCCC | 34.75 | 19823750 | |
| 38 | Phosphorylation | ASFKSKNSKTSTISK HHHCCCCCCCCCCCC | 40.84 | 19823750 | |
| 40 | Phosphorylation | FKSKNSKTSTISKDA HCCCCCCCCCCCCCC | 30.81 | 19823750 | |
| 41 | Phosphorylation | KSKNSKTSTISKDAK CCCCCCCCCCCCCCC | 27.72 | 19823750 | |
| 42 | Phosphorylation | SKNSKTSTISKDAKS CCCCCCCCCCCCCCC | 34.21 | 19823750 | |
| 44 | Phosphorylation | NSKTSTISKDAKSSS CCCCCCCCCCCCCCC | 25.27 | 19823750 | |
| 49 | Phosphorylation | TISKDAKSSSSLKIP CCCCCCCCCCCCEEE | 36.85 | 22369663 | |
| 50 | Phosphorylation | ISKDAKSSSSLKIPI CCCCCCCCCCCEEEC | 24.20 | 22369663 | |
| 51 | Phosphorylation | SKDAKSSSSLKIPIS CCCCCCCCCCEEECC | 46.94 | 21440633 | |
| 52 | Phosphorylation | KDAKSSSSLKIPISS CCCCCCCCCEEECCC | 35.31 | 21440633 | |
| 74 | Phosphorylation | SLAETNKYGMSSKPI EEEHHCCCCCCCCCC | 21.82 | 27214570 | |
| 181 | Phosphorylation | LIGLQNGSMIVYDID EEEECCCCEEEEEEC | 16.94 | 28889911 | |
| 335 | Phosphorylation | STNAAKISKVYWMCE CCCCCHHCEEEEEEC | 18.50 | 19779198 | |
| 349 | Phosphorylation | ENNPEYTSLLISHKS CCCHHHEEEEEECCC | 21.92 | 19779198 | |
| 358 | Phosphorylation | LISHKSISRGDNQSL EEECCCCCCCCCCEE | 36.98 | 19779198 | |
| 373 | Phosphorylation | TMIDLGYTPRYSITS EEEECCCCCCCEECC | 10.25 | 27017623 | |
| 377 | Phosphorylation | LGYTPRYSITSYEGM CCCCCCCEECCCCCH | 22.22 | 23749301 | |
| 381 | Phosphorylation | PRYSITSYEGMKNYY CCCEECCCCCHHHCC | 14.09 | 27017623 | |
| 512 | Phosphorylation | EYGTAFITGHSNGSV CCCCEEEECCCCCCE | 23.53 | 30377154 | |
| 542 | Phosphorylation | FEVNLSRTLNKAKEL EEEEHHHHHHHHHHH | 31.16 | 19779198 | |
| 591 | Phosphorylation | SVENRPESGDLEMNF EEECCCCCCCCCEEE | 40.05 | 28889911 | |
| 602 | Phosphorylation | EMNFRRFSLNNTNGV CEEEEEEEECCCCCE | 28.51 | 21440633 | |
| 606 | Phosphorylation | RRFSLNNTNGVLVDV EEEEECCCCCEEEEC | 32.07 | 25752575 | |
| 723 | Phosphorylation | TYKILPASGGKFDVQ EEEEEECCCCCEEEE | 46.25 | 17563356 | |
| 981 | Phosphorylation | PTRKGRNSSYGVLRN CCCCCCCCCHHHHHH | 24.47 | 25704821 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SRO7_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SRO7_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SRO7_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Phosphorylation | |
| Reference | PubMed |
| "A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-377; SER-591 ANDSER-602, AND MASS SPECTROMETRY. | |
| "Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases."; Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.; Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-723, AND MASSSPECTROMETRY. | |
