PDR16_YEAST - dbPTM
PDR16_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDR16_YEAST
UniProt AC P53860
Protein Name Phosphatidylinositol transfer protein PDR16
Gene Name PDR16
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 351
Subcellular Localization Lipid droplet. Microsome membrane
Peripheral membrane protein. Endoplasmic reticulum membrane
Peripheral membrane protein .
Protein Description Has phosphatidylinositol transfer activity. Involved in the regulation of the phospholipid composition of plasma- and endomembranes. Altering plasma membrane composition may provide a possible mechanism for multidrug resistance. Involved in the regulation of sterol biosynthesis. Contributes to efficient phospholipase D1 activation in the regulation of phospholipid turnover..
Protein Sequence MFKRFSKKKEAPEDPKNLINIDKPIKELPASIAIPKEKPLTGEQQKMYDEVLKHFSNPDLKVYTSEKNKSEDDLKPLEEEEKAWLTRECFLRYLRATKWVLKDCIDRITMTLAWRREFGISHLGEEHGDKITADLVAVENESGKQVILGYENDARPILYLKPGRQNTKTSHRQVQHLVFMLERVIDFMPAGQDSLALLIDFKDYPDVPKVPGNSKIPPIGVGKEVLHILQTHYPERLGKALLTNIPWLAWTFLKLIHPFIDPLTREKLVFDEPFVKYVPKNELDSLYGGDLKFKYNHDVYWPALVETAREKRDHYFKRFQSFGGIVGLSEVDLRGTHEKLLYPVKSESSTV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
16AcetylationKEAPEDPKNLINIDK
CCCCCCHHHCCCCCC		76.3724489116
26UbiquitinationINIDKPIKELPASIA
CCCCCCHHHCCCCEE		62.8224961812
53AcetylationKMYDEVLKHFSNPDL
HHHHHHHHHCCCCCC		48.0224489116
70PhosphorylationYTSEKNKSEDDLKPL
EECCCCCCHHHCCCC		56.5028889911
130AcetylationLGEEHGDKITADLVA
CCHHHCCEEEEEEEE		46.6924489116
223AcetylationIPPIGVGKEVLHILQ
CCCCCCCHHHHHHHH		42.0924489116
280AcetylationPFVKYVPKNELDSLY
CHHHCCCHHHHHHHC		53.6724489116
292AcetylationSLYGGDLKFKYNHDV
HHCCCCEEEEECCCC		44.5424489116
294AcetylationYGGDLKFKYNHDVYW
CCCCEEEEECCCCCH		43.4824489116
342PhosphorylationGTHEKLLYPVKSESS
CCCCCCEEECCCCCC		19.2030377154
345UbiquitinationEKLLYPVKSESSTV-
CCCEEECCCCCCCC-		43.9623749301
346PhosphorylationKLLYPVKSESSTV--
CCEEECCCCCCCC--		42.8322369663
348PhosphorylationLYPVKSESSTV----
EEECCCCCCCC----		38.1022369663
349PhosphorylationYPVKSESSTV-----
EECCCCCCCC-----		29.1922369663
350PhosphorylationPVKSESSTV------
ECCCCCCCC------		39.2422369663
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDR16_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDR16_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDR16_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PDR17_YEASTPDR17genetic
9890948
PDR5_YEASTPDR5genetic
9890948
PEX22_YEASTPEX22genetic
20093466
ARF1_YEASTARF1genetic
20093466
ASK10_YEASTASK10genetic
20093466
YOR1_YEASTYOR1genetic
20093466
ATG32_YEASTATG32genetic
20093466
CSF1_YEASTCSF1genetic
20093466
CBS_YEASTCYS4genetic
21987634
VPS27_YEASTVPS27genetic
21987634
PDE2_YEASTPDE2genetic
21987634
PDR16_YEASTPDR16physical
22102037
PDR16_YEASTPDR16physical
23519406
PDR16_YEASTPDR16physical
23603387
BPH1_YEASTBPH1genetic
23891562
UME6_YEASTUME6genetic
27708008
YOR1_YEASTYOR1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
TED1_YEASTTED1genetic
27708008
MTC2_YEASTMTC2genetic
27708008
CSF1_YEASTCSF1genetic
27708008
MDM38_YEASTMDM38genetic
27708008
PDR16_YEASTPDR16physical
24403601
LEM3_YEASTLEM3genetic
29240942
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDR16_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-346; SER-348; SER-349AND THR-350, AND MASS SPECTROMETRY.

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