| UniProt ID | BPH1_YEAST | |
|---|---|---|
| UniProt AC | P25356 | |
| Protein Name | Beige protein homolog 1 | |
| Gene Name | BPH1 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 2167 | |
| Subcellular Localization |
Cytoplasm . Membrane Peripheral membrane protein Cytoplasmic side . |
|
| Protein Description | May be involved in protein sorting and cell wall formation.. | |
| Protein Sequence | MNSIINAASKVLRLQDDVKKATIILGDILILQPINHEVEPDVENLVQHELTKIIQGYPIQDNMIINSKKGTVEDDLCELNNYTCFALSKSFDLCHDSRNFNIAQPKRWIQLLETLTDSVSFAVIVQIILTLSNISLINKQTLGKLKKLRIRIFEILSNKNDSWKSTLLQKNLIEWYIFMLSVDCTPLELQNLYLHKELKFCNGILNSLTLQVSDPRSQNYLQFENTYKLFQIQKSSRINNSFLFYIEFNSVTSNRIMTIERHIYLEIKEGQFCISNDNYIIGLFENFEFEAGTLYFIGVLIDHNNRITLYVDGSMINQLTLFENSICQLSTCELGSMICSIKVYRFYLWDGLLTEFAINILQAIGTNYQYTFSKKKEGPEVLSLCQDFLIAKAHLMARPTTEISSTKYIDEIELLEMENIIIDVNPNDILQDFTESSNFTVKFEESTNSKNIPEVGKCYFYRSSNLVSKFVSIDSIRLAFLNMTESGSIDDLFHHVSHLMNLLRNIDILNWFKKDFGFPLFAYTLKQKITQDLSQPLNIQFFNLFLEFCGWDFNDISKSIILDTDAYENIVLNLDLWYMNEDQSSLASGGLEIIRFLFFQISSLMEASIYSKFNSNKFNDMNILEKLCLSYQAVTKRENQNSKFNELSSDLISVFVTLLKSNTDKRHLQWFLHLSYYFIKRKDVRSTEIILQAVDQLFSFYLDQGSDENAKILSEIIPLKLILMIMDQIVENNESNPITCLNILFKVVLTNKPLFKQFYKNDGLKLILTMLCKVGKSYREEIISLLLTYSIGNYTTANEIFSGAEDMIGGISNDKITAKEIIYLAVNFIEWHVINSNASDSSSVLDLNNHILRFVEDLKSLSAVPINESVFDPKKSYVMVSLLDLSIALNESEDISKFKSSSKVISELIKGNIMCALTKYAAYDFEVYMSTFFCHSTEYKLVYPKTVMNNSSYLELSFIVTLLPEILNDLVDSNNNLNLMMLKHPYTMSNLLYFLRKFRPDTSQIVMPKDFYFSSYTCLLHCVIQIDKSSFYHFKNVSKSQLLQDFKICIMNLIYSNTLKQIIWEKEEYEMFSESLMAHQEVLFAHGACDNETVGLLLIFFANRLRDCGYNKAVFNCMKVIIKNKERKLKEVACFFDPANKSEVLEGLSNILSCNNSETMNLITEQYPFFFNNTQQVRFINIVTNILFKNNNFSPISVRQIKNQVYEWKNARSEYVTQNNKKCLILFRKDNTSLDFKIKKSISRYTYNLKTDREENAVFYRNNLNLLIFHLKHTLEIQSNPNSSCKWSSDFAEDFDGMKRRLLPAWEPKYEPLINEEDANQDTITGGNRQRRESGSILSYEFIEHMETLESEPVGDLNENRKILRLLKDNDSIATIWNCSLIIGLEIKEGILIHGSNYLYFVSDYYFSLEDKKILKLSEVSQESRDMTVSLINGPDVKRVSTFLKHEVFVWKLLDITFVTKRPFLLRDVAIELLFKERVSAFFSFYNKRVRDDVLRVLNKIPKHLPADPIFSSVLQEINDRGNSIVARNGIGKASIASKFTSVFSANNSLIDGFEISKKWVRGEISNFYYLLSINILAGRSFNDLTQYPVFPWVIADYESNVLDLENPKTYRDLSKPMGAQSEKRKLQFIERYEALASLENADSAPFHYGTHYSSAMIVSSYLIRLKPFVESFLLLQGGSFGPADRLFSSLERAWSSASSENTTDVRELTPEFFFLPEFLINVNSYDFGTDQSGKKVDDVVLPPWANGDPKVFIQKNREALESPYVSAHLHEWIDLIFGYKQKGDIAVKSVNVFNRLSYPGAVNLDNIDDENERRAITGIIHNFGQTPLQIFQEPHPEKIACNVQQLTTEVWRKVPMKPIFEKTIFNLNEKNRSVDYVIHDPSYFDSLYWRGFAFPNLFFRTEESLVSLRIVHKNWLKIGLDIFKKTHMAQITSFAYWKLGEFITGDKNGLIKVWKYRKDKHSVSGNLENKKTMFGHLCELKEMRCYHDYNTLLTLDISGLVYVWDMINFELVRQITNDAQKVAISQHAGSIMVLTKNNAISIFNLNGQIYTSKKFEPAKIVSSIDFFDFTKLDAGYRKHIYWKEMEILLVGFEDGTIEIYELFLNFHNEWAIKLLKQLCTEKGKAITSIKGQGKTYLSQKRRKDTAEPHEIEVIAGTLDGRLAIWY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 450 | Ubiquitination | FEESTNSKNIPEVGK EEECCCCCCCCCCCE | 62.05 | 23749301 | |
| 986 | Phosphorylation | LMMLKHPYTMSNLLY EEEECCCCHHHHHHH | 18.13 | 27017623 | |
| 987 | Phosphorylation | MMLKHPYTMSNLLYF EEECCCCHHHHHHHH | 20.69 | 27017623 | |
| 989 | Phosphorylation | LKHPYTMSNLLYFLR ECCCCHHHHHHHHHH | 19.27 | 27017623 | |
| 1247 | Phosphorylation | KSISRYTYNLKTDRE HHHHHEEEECCCCCH | 15.01 | 27017623 | |
| 1428 | Phosphorylation | SQESRDMTVSLINGP CHHHCCCEEEECCCC | 15.95 | 25521595 | |
| 1430 | Phosphorylation | ESRDMTVSLINGPDV HHCCCEEEECCCCCH | 17.86 | 28889911 | |
| 1626 | Acetylation | GAQSEKRKLQFIERY CCCCHHHHHHHHHHH | 58.68 | 24489116 | |
| 1667 | Ubiquitination | SSYLIRLKPFVESFL HHHHHHHHHHHHHHH | 26.93 | 22106047 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BPH1_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BPH1_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BPH1_YEAST !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| VPS9_YEAST | VPS9 | genetic | 15296494 | |
| FLO1_YEAST | FLO1 | genetic | 15296494 | |
| FLO9_YEAST | FLO9 | genetic | 15296494 | |
| GGPPS_YEAST | BTS1 | genetic | 15296494 | |
| OKP1_YEAST | OKP1 | genetic | 15296494 | |
| PSA3_YEAST | PRE9 | genetic | 23891562 | |
| ECM34_YEAST | ECM34 | genetic | 23891562 | |
| EPT1_YEAST | EPT1 | genetic | 23891562 | |
| KTR7_YEAST | KTR7 | genetic | 23891562 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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