EPT1_YEAST - dbPTM
EPT1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EPT1_YEAST
UniProt AC P22140
Protein Name Choline/ethanolaminephosphotransferase 1
Gene Name EPT1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 391
Subcellular Localization Golgi apparatus membrane
Multi-pass membrane protein.
Protein Description Catalyzes the final step in the CDP-ethanolamine route leading to phosphatidylethanolamine (PE). Can also catalyze the formation of phosphatidylcholine (PC) from CDP-choline, but does not substantially contribute to PC biosynthesis. Preferentially uses CDP-dimethylethanolamine and CDP-propanolamine as aminoalcohol substrates. Shows highest activity toward di-unsaturated diacylglycerol species as lipid substrates. The CDP-ethanolamine pathway may play a role in maintaining the proper PE species distribution..
Protein Sequence MGYFVPDSHIENLKSYKYQSEDRSLVSKYFLKPFWQRFCHIFPTWMAPNIITLSGFAFIVINVLTVFYYDPNLNTDTPRWTYFSYALGVFLYQTFDGCDGVHARRINQSGPLGELFDHSIDAINSTLSIFIFASETGMGFSYNLMLSQFAMLTNFYLSTWEEYHTHTLYLSEFSGPVEGILIVCVSLILTGIYGKQVIWHTYLFTITVGDKVIDVDTLDIVFSLAVFGLVMNALSAKRNVDKYYRNSTSSANNITQIEQDSAIKGLLPFFAYYASIALLVWMQPSFITLSFILSVGFTGAFTVGRIIVCHLTKQSFPMFNAPMLIPLCQIVLYKICLSLWGIESNKIVFALSWLGFGLSLGVHIMFMNDIIHEFTEYLDVYALSIKRSKLT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
28AcetylationEDRSLVSKYFLKPFW
CCCCHHHHHHHHHHH		32.3224489116
32AcetylationLVSKYFLKPFWQRFC
HHHHHHHHHHHHHHH		28.4124489116
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EPT1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EPT1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EPT1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PMA1_YEASTPMA1genetic
16269340
IRE1_YEASTIRE1genetic
16269340
YGB0_YEASTMPO1genetic
16269340
PLMT_YEASTOPI3genetic
16269340
TMEDA_YEASTERV25physical
18467557
CPT1_YEASTCPT1physical
18467557
RBD2_YEASTRBD2physical
18467557
SEC62_YEASTSEC62physical
18719252
GST1_YEASTGTT1physical
18719252
YAJ3_YEASTYAR023Cgenetic
20093466
YAJ9_YEASTYAR029Wgenetic
20093466
YPQ3_YEASTRTC2genetic
20093466
MIC12_YEASTMIC12genetic
20093466
GLYM_YEASTSHM1genetic
20093466
RBSK_YEASTRBK1genetic
20093466
MSH3_YEASTMSH3genetic
20093466
AIR2_YEASTAIR2genetic
20093466
UGA3_YEASTUGA3genetic
20093466
PCL2_YEASTPCL2genetic
20093466
AIM7_YEASTAIM7genetic
20093466
RAD55_YEASTRAD55genetic
20093466
YD132_YEASTYDR132Cgenetic
20093466
NBP2_YEASTNBP2genetic
20093466
CSN9_YEASTCSN9genetic
20093466
PEX10_YEASTPEX10genetic
20093466
ZIP1_YEASTZIP1genetic
20093466
PMT7_YEASTPMT7genetic
20093466
YFT2_YEASTYFT2genetic
20093466
ASPG1_YEASTASP1genetic
20093466
EAF1_YEASTEAF1genetic
20093466
CAJ1_YEASTCAJ1genetic
20093466
YOR1_YEASTYOR1genetic
20093466
BFA1_YEASTBFA1genetic
20093466
SWI6_YEASTSWI6genetic
20093466
VRP1_YEASTVRP1genetic
20093466
PML39_YEASTPML39genetic
20093466
PEX12_YEASTPEX12genetic
20093466
PEX15_YEASTPEX15genetic
20093466
YO223_YEASTDSC3genetic
20093466
PRM4_YEASTPRM4genetic
20093466
TKT1_YEASTTKL1genetic
20093466
PHO88_YEASTPHO88physical
16093310
MKAR_YEASTIFA38physical
16093310
ATU1_YEASTPCA1physical
16093310
ELO2_YEASTELO2physical
16093310
YET1_YEASTYET1physical
16093310
ELO3_YEASTELO3physical
16093310
ALG5_YEASTALG5physical
16093310
EPT1_YEASTEPT1physical
16093310
CSG2_YEASTCSG2genetic
21623372
FOLE_YEASTMET7genetic
21623372
SNF5_YEASTSNF5genetic
27708008
MFG1_YEASTMFG1genetic
27708008
TDA8_YEASTTDA8genetic
27708008
ARA1_YEASTARA1genetic
27708008
YPC1_YEASTYPC1genetic
27708008
MIC12_YEASTMIC12genetic
27708008
REI1_YEASTREI1genetic
27708008
ATU1_YEASTPCA1genetic
27708008
MGR1_YEASTMGR1genetic
27708008
RBSK_YEASTRBK1genetic
27708008
RS29B_YEASTRPS29Bgenetic
27708008
RLA1_YEASTRPP1Agenetic
27708008
PCL2_YEASTPCL2genetic
27708008
CG23_YEASTCLB3genetic
27708008
DLD1_YEASTDLD1genetic
27708008
RL41A_YEASTRPL41Agenetic
27708008
RL41B_YEASTRPL41Agenetic
27708008
SPO71_YEASTSPO71genetic
27708008
YD132_YEASTYDR132Cgenetic
27708008
CSN9_YEASTCSN9genetic
27708008
PEX10_YEASTPEX10genetic
27708008
MRX10_YEASTYDR282Cgenetic
27708008
ASPG1_YEASTASP1genetic
27708008
CAJ1_YEASTCAJ1genetic
27708008
MRM2_YEASTMRM2genetic
27708008
BUB1_YEASTBUB1genetic
27708008
YOR1_YEASTYOR1genetic
27708008
SNF6_YEASTSNF6genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
SPH1_YEASTSPH1genetic
27708008
SST2_YEASTSST2genetic
27708008
PML39_YEASTPML39genetic
27708008
YO13A_YEASTYOL013W-Agenetic
27708008
EXO1_YEASTEXO1genetic
27708008
PRM4_YEASTPRM4genetic
27708008
TKT1_YEASTTKL1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EPT1_YEAST

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Related Literatures of Post-Translational Modification

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