GLYM_YEAST - dbPTM
GLYM_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GLYM_YEAST
UniProt AC P37292
Protein Name Serine hydroxymethyltransferase, mitochondrial
Gene Name SHM1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 490
Subcellular Localization Mitochondrion.
Protein Description Interconversion of serine and glycine..
Protein Sequence MFPRASALAKCMATVHRRGLLTSGAQSLVSKPVSEGDPEMFDILQQERHRQKHSITLIPSENFTSKAVMDLLGSELQNKYSEGYPGERYYGGNEIIDKSESLCQARALELYGLDPAKWGVNVQPLSGAPANLYVYSAIMNVGERLMGLDLPDGGHLSHGYQLKSGTPISFISKYFQSMPYHVDHTTGLIDYDNLQVLAKAFRPKVIVAGTSAYSRLIDYARFKEISQGCGAYLMSDMAHISGLVAANVVPSPFEHSDIVTTTTHKSLRGPRGAMIFFRKGIKSVTKKGKEIPYELEKKINFSVFPGHQGGPHNHTIGAMAVALKQAMSPEFKEYQQKIVDNSKWFAQELTKMGYKLVSGGTDNHLIVIDLSGTQVDGARVETILSALNIAANKNTIPGDKSALFPSGLRIGTPAMTTRGFGREEFSQVAKYIDSAVKLAENLKTLEPTTKLDARSRLNEFKKLCNESSEVAALSGEISKWVGQYPVPGDI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
52AcetylationQQERHRQKHSITLIP
HHHHHHHCCCEEEEC		39.0024489116
64PhosphorylationLIPSENFTSKAVMDL
EECCCCCCCHHHHHH		40.6821440633
98AcetylationGGNEIIDKSESLCQA
CCCCCCCCCHHHHHH		45.7924489116
163AcetylationLSHGYQLKSGTPISF
CCCCEECCCCCCHHH		31.1724489116
164PhosphorylationSHGYQLKSGTPISFI
CCCEECCCCCCHHHH		57.3922369663
166PhosphorylationGYQLKSGTPISFISK
CEECCCCCCHHHHHH		25.2521440633
169PhosphorylationLKSGTPISFISKYFQ
CCCCCCHHHHHHHHH		20.1021440633
172PhosphorylationGTPISFISKYFQSMP
CCCHHHHHHHHHCCC		21.2019823750
199AcetylationDNLQVLAKAFRPKVI
CHHHHHHHHHCCEEE		43.8524489116
210PhosphorylationPKVIVAGTSAYSRLI
CEEEEECCCHHHHHH		10.6328889911
211PhosphorylationKVIVAGTSAYSRLID
EEEEECCCHHHHHHH		25.0425752575
265OtherIVTTTTHKSLRGPRG
CEEECCCHHHCCCCC		49.44-
265N6-(pyridoxal phosphate)lysineIVTTTTHKSLRGPRG
CEEECCCHHHCCCCC		49.44-
289AcetylationKSVTKKGKEIPYELE
HHHHCCCCCCCHHHH		62.4424489116
297SuccinylationEIPYELEKKINFSVF
CCCHHHHHCCCEEEC		72.1323954790
297AcetylationEIPYELEKKINFSVF
CCCHHHHHCCCEEEC		72.1324489116
332SuccinylationQAMSPEFKEYQQKIV
HHCCHHHHHHHHHHH		54.5823954790
3372-HydroxyisobutyrylationEFKEYQQKIVDNSKW
HHHHHHHHHHHCHHH		29.22-
343AcetylationQKIVDNSKWFAQELT
HHHHHCHHHHHHHHH		53.2224489116
351AcetylationWFAQELTKMGYKLVS
HHHHHHHHHCCEEEE		42.8424489116
400AcetylationKNTIPGDKSALFPSG
CCCCCCCHHHHCCCC		43.4724489116
417PhosphorylationIGTPAMTTRGFGREE
CCCCCCCCCCCCHHH		18.7328132839
430AcetylationEEFSQVAKYIDSAVK
HHHHHHHHHHHHHHH		43.8324489116
431PhosphorylationEFSQVAKYIDSAVKL
HHHHHHHHHHHHHHH		10.5421440633
437AcetylationKYIDSAVKLAENLKT
HHHHHHHHHHHHHCC		41.5224489116
443AcetylationVKLAENLKTLEPTTK
HHHHHHHCCCCCCCH		63.7524489116
443SuccinylationVKLAENLKTLEPTTK
HHHHHHHCCCCCCCH		63.7523954790
450AcetylationKTLEPTTKLDARSRL
CCCCCCCHHHHHHHH		47.0124489116
450SuccinylationKTLEPTTKLDARSRL
CCCCCCCHHHHHHHH		47.0123954790
468PhosphorylationKKLCNESSEVAALSG
HHHHCCCHHHHHHHH		29.8827017623
478PhosphorylationAALSGEISKWVGQYP
HHHHHHHHHHHCCCC		19.0327017623
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GLYM_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GLYM_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GLYM_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
C1TC_YEASTADE3genetic
12684846
GLYC_YEASTSHM2genetic
8852837
GLYC_YEASTSHM2genetic
16941010
I23O_YEASTBNA2genetic
16941010
KYNU_YEASTBNA5genetic
16941010
HOSC_YEASTLYS20genetic
20093466
SPS2_YEASTSPS2genetic
20093466
SNAPN_YEASTSNN1genetic
20093466
ATPK_YEASTATP17genetic
21623372
INO1_YEASTINO1genetic
21623372
ADH3_YEASTADH3genetic
21623372
YAJ9_YEASTYAR029Wgenetic
27708008
SEF1_YEASTSEF1genetic
27708008
HOSC_YEASTLYS20genetic
27708008
AVT6_YEASTAVT6genetic
27708008
PEX21_YEASTPEX21genetic
27708008
SNF6_YEASTSNF6genetic
27708008
SDO1L_YEASTRTC3genetic
27708008
SS100_YEASTSPS100genetic
27708008
YH10_YEASTYHR210Cgenetic
27708008
ORN_YEASTREX2genetic
27708008
UPS1_YEASTUPS1genetic
27708008
GOT1_YEASTGOT1genetic
27708008
SIW14_YEASTSIW14genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GLYM_YEAST

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Related Literatures of Post-Translational Modification

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