I23O_YEAST - dbPTM
I23O_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID I23O_YEAST
UniProt AC P47125
Protein Name Indoleamine 2,3-dioxygenase
Gene Name BNA2
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 453
Subcellular Localization
Protein Description Catalyzes the first step in tryptophan catabolism in order to supply de novo nicotinamide adenine dinucleotide (NAD(+)) via the kynurenine pathway. Plays a role in the cellular response to telomere uncapping..
Protein Sequence MNNTSITGPQVLHRTKMRPLPVLEKYCISPHHGFLDDRLPLTRLSSKKYMKWEEIVADLPSLLQEDNKVRSVIDGLDVLDLDETILGDVRELRRAYSILGFMAHAYIWASGTPRDVLPECIARPLLETAHILGVPPLATYSSLVLWNFKVTDECKKTETGCLDLENITTINTFTGTVDESWFYLVSVRFEKIGSACLNHGLQILRAIRSGDKGDANVIDGLEGLAATIERLSKALMEMELKCEPNVFYFKIRPFLAGWTNMSHMGLPQGVRYGAEGQYRIFSGGSNAQSSLIQTLDILLGVKHTANAAHSSQGDSKINYLDEMKKYMPREHREFLYHLESVCNIREYVSRNASNRALQEAYGRCISMLKIFRDNHIQIVTKYIILPSNSKQHGSNKPNVLSPIEPNTKASGCLGHKVASSKTIGTGGTRLMPFLKQCRDETVATADIKNEDKN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
209PhosphorylationQILRAIRSGDKGDAN
HHHHHHHCCCCCCCH		45.2727017623
227PhosphorylationGLEGLAATIERLSKA
HHHHHHHHHHHHHHH		20.1227017623
272PhosphorylationGLPQGVRYGAEGQYR
CCCCCCCCCCCCCEE		20.4827017623
278PhosphorylationRYGAEGQYRIFSGGS
CCCCCCCEEEECCCC		19.2827017623
285PhosphorylationYRIFSGGSNAQSSLI
EEEECCCCCHHHHHH		32.3027017623
416AcetylationASGCLGHKVASSKTI
CCCCCCCCCCCCCEE		37.3825381059
419PhosphorylationCLGHKVASSKTIGTG
CCCCCCCCCCEECCC		35.0425371407
420PhosphorylationLGHKVASSKTIGTGG
CCCCCCCCCEECCCH		24.8728889911
421AcetylationGHKVASSKTIGTGGT
CCCCCCCCEECCCHH		41.4825381059
422PhosphorylationHKVASSKTIGTGGTR
CCCCCCCEECCCHHC		26.9625371407
425PhosphorylationASSKTIGTGGTRLMP
CCCCEECCCHHCCHH		28.7025371407
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of I23O_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of I23O_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of I23O_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CAJ1_YEASTCAJ1genetic
20093466
DBP3_YEASTDBP3genetic
20093466
TNA1_YEASTTNA1genetic
20093466
TOK1_YEASTTOK1genetic
20093466
IMP2_YEASTIMP2genetic
20093466
MDM12_YEASTMDM12genetic
20093466
NPT1_YEASTNPT1genetic
20093466
TNA1_YEASTTNA1genetic
21623372
NPT1_YEASTNPT1genetic
21623372
GGPPS_YEASTBTS1genetic
21623372
THRC_YEASTTHR4genetic
21623372
GPR1_YEASTGPR1genetic
27708008
TNA1_YEASTTNA1genetic
27708008
YHK5_YEASTYHR045Wgenetic
27708008
IST3_YEASTIST3genetic
27708008
TOK1_YEASTTOK1genetic
27708008
IMP2_YEASTIMP2genetic
27708008
NPT1_YEASTNPT1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of I23O_YEAST

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Related Literatures of Post-Translational Modification

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