GPR1_YEAST - dbPTM
GPR1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GPR1_YEAST
UniProt AC Q12361
Protein Name G protein-coupled receptor GPR1
Gene Name GPR1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 961
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description Seems to associate with GPA2 and act as G protein-coupled receptor that senses glucose and controls filamentous growth. It acts upstream of adenylate cyclase and is required for glucose activation of cAMP synthesis in concert with a glucose phosphorylation-dependent mechanism..
Protein Sequence MITEGFPPNLNALKGSSLLEKRVDSLRQLNTTTVNQLLGLPGMTSTFTAPQLLQLRIIAITASAVSLIAGCLGMFFLSKMDKRRKVFRHDLIAFLIICDFLKAFILMIYPMIILINNSVYATPAFFNTLGWFTAFAIEGADMAIMIFAIHFAILIFKPNWKWRNKRSGNMEGGLYKKRSYIWPITALVPAILASLAFINYNKLNDDSDTTIILDNNNYNFPDSPRQGGYKPWSAWCYLPPKPYWYKIVLSWGPRYFIIIFIFAVYLSIYIFITSESKRIKAQIGDFNHNVLEEEKEKKKLFGLGHWGKAKWYFRSYFKLPLLHLLRNLKNFFTISFIDPNEETDDSGSSNGTFNFGESSNEIPTLFRKTNTGSDENVSASGGVRLLDYNSAKPLDMSKYAMSEQPDLERNNPFDCENDITLNPSELVSKQKEHKVTFSVENEGLDTRKSSMLGHQTFSCQNSLESPLAMYDNKNDNSDITSNIKEKGGIINNNSNNDDDDNNNNNDNDNDNNNSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSNNIKNNVDNNNTNPADNIPTLSNEAFTPSQQFSQERVNNNADRCENSSFTNVQQHFQAQTYKQMKKRRAQIQKNLRAIFIYPLSYIGIWLFPIIADALQYNHEIKHGPTMWVTYIDTCVRPLSCLVDVIVYLFKEKPWNYSWAKTESKYLIEKYILKGELGEKEILKFCHSNWGKRGWYYRGKWKKRKCWKYSTNPLKRILWFVERFFKQLFELKLHFSFYDNCDDFEYWENYYSAKDSNDNKRTESDETKTNSSDRSLPSNSLELQAMLNNITAEEVEVPLFWRIIHHIPMLGGIDLDELNRLLKIRYNNDHFSLPGLKFALNQNKSHDKHQDVSTNSMVKSSFFSSNIVTNDDENSIEEDKNLRYSDASASENYLVKPTIPGTTPDPIIEAQNDNDSSDSSGIDLIAFLRNGPL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
295AcetylationHNVLEEEKEKKKLFG
HHHHHHHHHHHCHHC		77.4524489116
335PhosphorylationLKNFFTISFIDPNEE
HCCCEEEEEECCCCC		17.0619779198
343PhosphorylationFIDPNEETDDSGSSN
EECCCCCCCCCCCCC		38.6419779198
352PhosphorylationDSGSSNGTFNFGESS
CCCCCCCEEECCCCC		21.4719779198
368UbiquitinationEIPTLFRKTNTGSDE
CCCCEEECCCCCCCC		38.5023749301
369PhosphorylationIPTLFRKTNTGSDEN
CCCEEECCCCCCCCC		33.4822369663
371PhosphorylationTLFRKTNTGSDENVS
CEEECCCCCCCCCCC		43.2122369663
373PhosphorylationFRKTNTGSDENVSAS
EECCCCCCCCCCCCC		39.4522369663
378PhosphorylationTGSDENVSASGGVRL
CCCCCCCCCCCCEEE		28.4419684113
390PhosphorylationVRLLDYNSAKPLDMS
EEEECCCCCCCCCHH		31.2923749301
392UbiquitinationLLDYNSAKPLDMSKY
EECCCCCCCCCHHHH		46.0323749301
398UbiquitinationAKPLDMSKYAMSEQP
CCCCCHHHHHHHCCC		30.3224961812
436PhosphorylationKQKEHKVTFSVENEG
CCCCCCCEEEEECCC		18.2621551504
438PhosphorylationKEHKVTFSVENEGLD
CCCCCEEEEECCCCC		21.1127017623
446PhosphorylationVENEGLDTRKSSMLG
EECCCCCCCHHHHCC		45.0721551504
462PhosphorylationQTFSCQNSLESPLAM
CCCCCCCCCCCCCCC		13.9721440633
465PhosphorylationSCQNSLESPLAMYDN
CCCCCCCCCCCCCCC		30.4327738172
477PhosphorylationYDNKNDNSDITSNIK
CCCCCCCCCCCHHHH		33.0022369663
480PhosphorylationKNDNSDITSNIKEKG
CCCCCCCCHHHHHHC		22.2524909858
481PhosphorylationNDNSDITSNIKEKGG
CCCCCCCHHHHHHCC		36.5722369663
567PhosphorylationADNIPTLSNEAFTPS
HHCCCCCCCCCCCHH		34.7923749301
592PhosphorylationNADRCENSSFTNVQQ
CCHHCCCCCCHHHHH		12.4421440633
593PhosphorylationADRCENSSFTNVQQH
CHHCCCCCCHHHHHH		47.9023749301
605PhosphorylationQQHFQAQTYKQMKKR
HHHHHHHHHHHHHHH		35.3830377154
790PhosphorylationDSNDNKRTESDETKT
CCCCCCCCCCCCCCC		41.2627717283
792PhosphorylationNDNKRTESDETKTNS
CCCCCCCCCCCCCCC		39.8827214570
854PhosphorylationNRLLKIRYNNDHFSL
HHHHHEECCCCCCCC		23.0719779198
860PhosphorylationRYNNDHFSLPGLKFA
ECCCCCCCCCHHHHH		30.1821440633
865UbiquitinationHFSLPGLKFALNQNK
CCCCCHHHHHHCCCC		34.2117644757
881PhosphorylationHDKHQDVSTNSMVKS
CCCCCCCCHHHHHHH		30.1121440633
882PhosphorylationDKHQDVSTNSMVKSS
CCCCCCCHHHHHHHH		31.0321440633
884PhosphorylationHQDVSTNSMVKSSFF
CCCCCHHHHHHHHHH		25.6621440633
897PhosphorylationFFSSNIVTNDDENSI
HHCCCCCCCCCCCCH		29.1829734811
903PhosphorylationVTNDDENSIEEDKNL
CCCCCCCCHHHCCCC		29.3625521595
908UbiquitinationENSIEEDKNLRYSDA
CCCHHHCCCCCCCCC		62.2523749301
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GPR1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GPR1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GPR1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SNF3_YEASTSNF3genetic
17428308
RGT2_YEASTRGT2genetic
17428308
MTH1_YEASTMTH1genetic
17428308
HXKA_YEASTHXK1genetic
17428308
HXKB_YEASTHXK2genetic
17428308
HXKG_YEASTGLK1genetic
17428308
HXKA_YEASTHXK1genetic
17311583
HXKB_YEASTHXK2genetic
17311583
HXKG_YEASTGLK1genetic
17311583
GPA2_YEASTGPA2genetic
10655215
RAS2_YEASTRAS2genetic
10655215
KAPB_YEASTTPK2genetic
10514491
RAS2_YEASTRAS2genetic
10514491
STE11_YEASTSTE11genetic
10514491
GPA2_YEASTGPA2genetic
18096414
YDC1_YEASTYDC1physical
18467557
URE2_YEASTURE2physical
18467557
ADT2_YEASTPET9genetic
19160490
PHB1_YEASTPHB1genetic
19160490
SCH9_YEASTSCH9genetic
19225458
APT2_YEASTAPT2genetic
20093466
BLM10_YEASTBLM10genetic
20093466
ATC1_YEASTPMR1genetic
20093466
PEX18_YEASTPEX18genetic
20093466
ACA2_YEASTCST6genetic
20093466
IST3_YEASTIST3genetic
20093466
PLMT_YEASTOPI3genetic
20093466
YJ90_YEASTYJR120Wgenetic
20093466
SAC1_YEASTSAC1genetic
20093466
IXR1_YEASTIXR1genetic
20093466
VRP1_YEASTVRP1genetic
20093466
PEX15_YEASTPEX15genetic
20093466
CSK22_YEASTCKA2genetic
20093466
CTI6_YEASTCTI6genetic
20093466
TSA1_YEASTTSA1genetic
21884982
GPA2_YEASTGPA2genetic
18622617
TPS2_YEASTTPS2genetic
22697265
SKS1_YEASTSKS1genetic
24603354
GPA2_YEASTGPA2genetic
25044394
ELM1_YEASTELM1genetic
26640955
RGT2_YEASTRGT2genetic
25541485
CTI6_YEASTCTI6genetic
27708008
SEC18_YEASTSEC18genetic
27708008
TBP_YEASTSPT15genetic
27708008
PRS8_YEASTRPT6genetic
27708008
ALG2_YEASTALG2genetic
27708008
ESP1_YEASTESP1genetic
27708008
ARP3_YEASTARP3genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
ERG27_YEASTERG27genetic
27708008
SC61A_YEASTSEC61genetic
27708008
RPC6_YEASTRPC34genetic
27708008
GPN2_YEASTGPN2genetic
27708008
APT2_YEASTAPT2genetic
27708008
BLM10_YEASTBLM10genetic
27708008
ATC1_YEASTPMR1genetic
27708008
HUR1_YEASTHUR1genetic
27708008
ACA2_YEASTCST6genetic
27708008
VPS53_YEASTVPS53genetic
27708008
IXR1_YEASTIXR1genetic
27708008
SAC1_YEASTSAC1genetic
27708008
DIA2_YEASTDIA2genetic
27708008
ISW2_YEASTISW2genetic
27708008
RGT2_YEASTRGT2genetic
29284676
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GPR1_YEAST

loading...

Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-373 AND SER-903, ANDMASS SPECTROMETRY.
"Proteome-wide identification of in vivo targets of DNA damagecheckpoint kinases.";
Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H.;
Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-369; THR-371 ANDSER-373, AND MASS SPECTROMETRY.
"Large-scale phosphorylation analysis of alpha-factor-arrestedSaccharomyces cerevisiae.";
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J.,Elias J.E., Gygi S.P.;
J. Proteome Res. 6:1190-1197(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-903, AND MASSSPECTROMETRY.

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory