HXKG_YEAST - dbPTM
HXKG_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID HXKG_YEAST
UniProt AC P17709
Protein Name Glucokinase-1
Gene Name GLK1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 500
Subcellular Localization
Protein Description Two isoenzymes, hexokinase-1 and hexokinase-2, can phosphorylate keto- and aldohexoses in yeast, whereas a third isoenzyme, GLK, is specific for aldohexoses. All glucose phosphorylating enzymes are involved in glucose uptake..
Protein Sequence MSFDDLHKATERAVIQAVDQICDDFEVTPEKLDELTAYFIEQMEKGLAPPKEGHTLASDKGLPMIPAFVTGSPNGTERGVLLAADLGGTNFRICSVNLHGDHTFSMEQMKSKIPDDLLDDENVTSDDLFGFLARRTLAFMKKYHPDELAKGKDAKPMKLGFTFSYPVDQTSLNSGTLIRWTKGFRIADTVGKDVVQLYQEQLSAQGMPMIKVVALTNDTVGTYLSHCYTSDNTDSMTSGEISEPVIGCIFGTGTNGCYMEEINKITKLPQELRDKLIKEGKTHMIINVEWGSFDNELKHLPTTKYDVVIDQKLSTNPGFHLFEKRVSGMFLGEVLRNILVDLHSQGLLLQQYRSKEQLPRHLTTPFQLSSEVLSHIEIDDSTGLRETELSLLQSLRLPTTPTERVQIQKLVRAISRRSAYLAAVPLAAILIKTNALNKRYHGEVEIGCDGSVVEYYPGFRSMLRHALALSPLGAEGERKVHLKIAKDGSGVGAALCALVA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSFDDLHKA
------CCHHHHHHH		37.0722814378
2Phosphorylation------MSFDDLHKA
------CCHHHHHHH		37.0722369663
8AcetylationMSFDDLHKATERAVI
CCHHHHHHHHHHHHH		65.3924489116
60AcetylationGHTLASDKGLPMIPA
CCCCCCCCCCCCCCE		60.9124489116
72PhosphorylationIPAFVTGSPNGTERG
CCEEEECCCCCCCEE		13.0630377154
76PhosphorylationVTGSPNGTERGVLLA
EECCCCCCCEEEEEE		29.2030377154
110AcetylationTFSMEQMKSKIPDDL
CCCHHHHHHCCCHHH		48.5724489116
142AcetylationRTLAFMKKYHPDELA
HHHHHHHHHCHHHHH		36.6825381059
150AcetylationYHPDELAKGKDAKPM
HCHHHHHCCCCCCCC		78.2022865919
174PhosphorylationVDQTSLNSGTLIRWT
CCCCCCCCCCEEEEC		38.1528889911
1822-HydroxyisobutyrylationGTLIRWTKGFRIADT
CCEEEECCCEEEECC		49.44-
266PhosphorylationMEEINKITKLPQELR
HHHHHHHHCCCHHHH		28.3022369663
267AcetylationEEINKITKLPQELRD
HHHHHHHCCCHHHHH		62.7422865919
267SuccinylationEEINKITKLPQELRD
HHHHHHHCCCHHHHH		62.7423954790
2782-HydroxyisobutyrylationELRDKLIKEGKTHMI
HHHHHHHHCCCCEEE		71.50-
304AcetylationLKHLPTTKYDVVIDQ
HCCCCCCCEEEEECC		41.7622865919
3042-HydroxyisobutyrylationLKHLPTTKYDVVIDQ
HCCCCCCCEEEEECC		41.76-
312AcetylationYDVVIDQKLSTNPGF
EEEEECCCCCCCCCC		40.4324489116
315PhosphorylationVIDQKLSTNPGFHLF
EECCCCCCCCCCCCE		56.7327017623
3242-HydroxyisobutyrylationPGFHLFEKRVSGMFL
CCCCCEEHHHHCHHH		51.25-
324AcetylationPGFHLFEKRVSGMFL
CCCCCEEHHHHCHHH		51.2524489116
327PhosphorylationHLFEKRVSGMFLGEV
CCEEHHHHCHHHHHH		28.6822369663
3552-HydroxyisobutyrylationLLQQYRSKEQLPRHL
HHHHHCCHHHCCHHC		40.24-
355UbiquitinationLLQQYRSKEQLPRHL
HHHHHCCHHHCCHHC		40.2423749301
409AcetylationTERVQIQKLVRAISR
CHHHHHHHHHHHHHH		51.0525381059
418PhosphorylationVRAISRRSAYLAAVP
HHHHHHHHHHHHHHH		21.8330377154
4382-HydroxyisobutyrylationIKTNALNKRYHGEVE
HHHCCCCCCCCCEEE		56.00-
470PhosphorylationLRHALALSPLGAEGE
HHHHHHHCCCCCCCC		16.6925752575
4832-HydroxyisobutyrylationGERKVHLKIAKDGSG
CCEEEEEEECCCCCC		26.24-
489PhosphorylationLKIAKDGSGVGAALC
EEECCCCCCHHHHHH		40.2030377154
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of HXKG_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of HXKG_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of HXKG_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARGR2_YEASTARG81physical
10688190
FIG1_YEASTFIG1physical
10688190
HXKA_YEASTHXK1genetic
10217505
HXKB_YEASTHXK2genetic
10217505
HXKG_YEASTGLK1physical
11283351
HXKA_YEASTHXK1genetic
16941010
HXKB_YEASTHXK2genetic
16941010
GGPPS_YEASTBTS1genetic
21623372
ELO3_YEASTELO3genetic
21623372
CALM_YEASTCMD1genetic
27708008
MPS1_YEASTMPS1genetic
27708008
PRP9_YEASTPRP9genetic
27708008
SNU23_YEASTSNU23genetic
27708008
CDC48_YEASTCDC48genetic
27708008
DAD1_YEASTDAD1genetic
27708008
RRP1_YEASTRRP1genetic
27708008
NBP35_YEASTNBP35genetic
27708008
PRP43_YEASTPRP43genetic
27708008
BRL1_YEASTBRL1genetic
27708008
KRE9_YEASTKRE9genetic
27708008
YJ9I_YEASTYJR141Wgenetic
27708008
NMT_YEASTNMT1genetic
27708008
NAB3_YEASTNAB3genetic
27708008
IF6_YEASTTIF6genetic
27708008
KEAP1_HUMANKEAP1physical
27107014
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of HXKG_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-174 AND SER-470,AND MASS SPECTROMETRY.

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