dbPTM

ARGR2_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ARGR2_YEAST
UniProt AC	P05085
Protein Name	Arginine metabolism regulation protein II
Gene Name	ARG81
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	880
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	With ARG80, ARG82 and MCM1, coordinates the expression of arginine anabolic and catabolic genes in response to arginine..
Protein Sequence	MGISSKNGPKKMGRAKTFTGCWTCRGRKVKCDLRHPHCQRCEKSNLPCGGYDIKLRWSKPMQFDPYGVPIPQNSPATTTNLSGSVDEPQYQRRNIDFVRYDEEYVYHEDMDDELTMLHTPPIEKISDNKTWIIKKFGVFKGTDKIDKQYAPRKKRNRKRVAKSLESSASISLSSLPSSSTISFPIRHIEDKLRNKGHVKTGILSANDGVPPTPNLLDYDWNNLNITGYEWISSELRDDALLSAVTLQGHHLGHTQPQEISLEENSNVVSGEEHVNAKEHGCAFEADNQGSSTLPNKAASANDKLYQQNLKLLFQKNSSNSEEPDPQALIDDVFVNIEPRSLPASDLNKITLAPPNEESRMPKSMLELTSYSSDLPPELVDIIPKTDLTVHGLARFLLNHYFNNVADKMTVVVLEKNPWKTLYFPRALMALGDLAGLGQSSNSRNALLNALLAVSCFHLQSKYPRNYKLQKYFLGLGIELRNQASNFLRLCLNTKSSIPEKYKDVLTAILSMNSIDVVWGTMADCQDHLALCEDFVESRMKLRPNISEKTKTLHRIFSFLKLIQDSTALDKVRAKEIVILPSEEDDNYKPLDTSNATTSSSEPRVDVVQEGLFREALNENDGKIHIEFVKEPITNVSADSTPSSTTPPIFTNIATESYYNKSDISKLVSKTDENIIGTDSLYGLPNSLILLFSDCVRIVRHNEYYNLTYLPVPRKFNELSLNFEKRLLKWKSEWNFHQENSEGKSFINSTAEALYHHTMSFYFSLIIYYFTMARSLNCQFLQNYVAKVLDHLNAMEELVDQKKVKIVPLIWQGFMAGCACTDENRQQEFRRWAAKLAESGVGSYWGARQVMLEVWRRRKEDEPGDNWYSVYKDWEMNLMLS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
130	Phosphorylation	EKISDNKTWIIKKFG HHCCCCCCEEEEECC	28.31	27017623
177	Phosphorylation	ISLSSLPSSSTISFP EECHHCCCCCEEEEE	42.06	28889911
501	Phosphorylation	KSSIPEKYKDVLTAI CCCCCHHHHHHHHHH	15.68	25533186

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ARGR2_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ARGR2_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ARGR2_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARGR1_YEAST	ARG80	physical	10632874
ARGR2_YEAST	ARG81	physical	10632874
MCM1_YEAST	MCM1	physical	10632874
UME6_YEAST	UME6	physical	10809695
ARGR1_YEAST	ARG80	physical	10688655
MCM1_YEAST	MCM1	physical	10688655
PACC_YEAST	RIM101	genetic	21127252
RSC1_YEAST	RSC1	genetic	21127252
KCS1_YEAST	KCS1	genetic	21127252
RTG3_YEAST	RTG3	genetic	21127252
UME6_YEAST	UME6	genetic	21127252
BCK1_YEAST	BCK1	genetic	21127252
SWI4_YEAST	SWI4	genetic	21127252
HAC1_YEAST	HAC1	genetic	21127252
RXT2_YEAST	RXT2	genetic	21127252
MED6_YEAST	MED6	genetic	27708008
CLP1_YEAST	CLP1	genetic	27708008
SNF5_YEAST	SNF5	genetic	27708008
MRM2_YEAST	MRM2	genetic	27708008
CSN12_YEAST	YJR084W	genetic	27708008
TECR_YEAST	TSC13	genetic	27708008
SNU23_YEAST	SNU23	genetic	27708008
MOB2_YEAST	MOB2	genetic	27708008
ACT_YEAST	ACT1	genetic	27708008
BIG1_YEAST	BIG1	genetic	27708008
CBF3B_YEAST	CEP3	genetic	27708008
LCB1_YEAST	LCB1	genetic	27708008
DBP6_YEAST	DBP6	genetic	27708008
NUF2_YEAST	NUF2	genetic	27708008
SYA_YEAST	ALA1	genetic	27708008
TBF1_YEAST	TBF1	genetic	27708008
ARP7_YEAST	ARP7	genetic	27708008
DIB1_YEAST	DIB1	genetic	27708008
RS8A_YEAST	RPS8A	genetic	27708008
RS8B_YEAST	RPS8A	genetic	27708008
RV161_YEAST	RVS161	genetic	27708008
RIM1_YEAST	RIM1	genetic	27708008
TPS2_YEAST	TPS2	genetic	27708008
BCS1_YEAST	BCS1	genetic	27708008
XRN1_YEAST	XRN1	genetic	27708008
VMA21_YEAST	VMA21	genetic	27708008
QCR9_YEAST	QCR9	genetic	27708008
RS27B_YEAST	RPS27B	genetic	27708008
PTK2_YEAST	PTK2	genetic	27708008
SIC1_YEAST	SIC1	genetic	27708008
ELP1_YEAST	IKI3	genetic	27708008
SWS2_YEAST	SWS2	genetic	27708008
FAR11_YEAST	FAR11	genetic	27708008
CUZ1_YEAST	CUZ1	genetic	27708008
CY1_YEAST	CYT1	genetic	27708008
SUR1_YEAST	SUR1	genetic	27708008
YP162_YEAST	YPL162C	genetic	27708008
UBA3_YEAST	UBA3	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ARGR2_YEAST

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis."; Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.; Mol. Cell. Proteomics 7:1389-1396(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177, AND MASSSPECTROMETRY.	18407956 [Abstract]