TBF1_YEAST - dbPTM
TBF1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TBF1_YEAST
UniProt AC Q02457
Protein Name Protein TBF1
Gene Name TBF1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 562
Subcellular Localization Nucleus . Chromosome, telomere . Localizes to synapsed chromosomes during meiosis.
Protein Description Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of gene expression. 52 binding sites have been identified, distributed over 15 chromosomes. A member of the general regulatory factors (GRFs) which act as genome partitioners. Acts as a chromatin insulator which are known as STARs (Subtelomeric anti-silencing region). STARs prevent negative or positive transcription influence by extending across chromotin to a promoter..
Protein Sequence MDSQVPNNNESLNRFNDIIQSLPARTRLTICSLCLLDNISTQLLRFLILNANSPNIIAVLTDQTAFLSSGETEIFQTLVKLFKQIRMIYHTRSPLLSVHDVAPGLWFPNSPPPLILRGHEAFIITAIRKANLLTFLLTSLNCLNYGFELLQSIFLDIFCPNTNTVGNNSLEQSGKFLKSQAILYLDLKTQAYIAGLKEFQDETNEISLEKKQELLDLIFPSNLADILVQRRTGDSGDITLLTPSEKDFVERCDRRRENLKIVQDFNSLTQSYEWAQFIRELLDYCNKNMGLIIWGRKGRGKSPLYDFDVNEFDPQVLFSTGTRTVEFMDDQNQPSSASAFLSTARPNHYSTHTPTTDVSSKNPAITQSIVDAAVAASMSNSSSGPHSSHNNSSNSNNNGSIGLRKPKAKRTWSKEEEEALVEGLKEVGPSWSKILDLYGPGGKITENLKNRTQVQLKDKARNWKLQYLKSGKPLPDYLIKVTGNLEKIYKAKKKFSQSPNSSTIMEQNLSQHPSSAASATEDTQTHQEDSHGQNSDNMPSNGLFGNSTSDNTGFDPHLEDGM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
242PhosphorylationSGDITLLTPSEKDFV
CCCEEEECCCHHHHH		28.0723749301
350PhosphorylationTARPNHYSTHTPTTD
CCCCCCCCCCCCCCC		13.2328132839
351PhosphorylationARPNHYSTHTPTTDV
CCCCCCCCCCCCCCC		23.7028132839
411PhosphorylationRKPKAKRTWSKEEEE
CCCCCCCCCCHHHHH		33.1230377154
413PhosphorylationPKAKRTWSKEEEEAL
CCCCCCCCHHHHHHH		29.5830377154
443UbiquitinationDLYGPGGKITENLKN
HHHCCCCHHHHHHCC		52.9823749301
469UbiquitinationNWKLQYLKSGKPLPD
HHHHEHHHCCCCCCC		52.8322817900
472UbiquitinationLQYLKSGKPLPDYLI
HEHHHCCCCCCCEEE		50.9322817900
487AcetylationKVTGNLEKIYKAKKK
EHHCCHHHHHHHHHH		55.2725381059
489PhosphorylationTGNLEKIYKAKKKFS
HCCHHHHHHHHHHHC		18.8927017623
498PhosphorylationAKKKFSQSPNSSTIM
HHHHHCCCCCHHHHH		25.5028889911
501PhosphorylationKFSQSPNSSTIMEQN
HHCCCCCHHHHHHHH		32.0428889911
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TBF1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TBF1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TBF1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
VID22_YEASTVID22physical
16429126
VID22_YEASTVID22genetic
17314980
COG8_YEASTCOG8genetic
17314980
YPT6_YEASTYPT6genetic
17314980
PBP4_YEASTPBP4genetic
17314980
RIC1_YEASTRIC1genetic
17314980
VID22_YEASTVID22physical
20620961
ENV11_YEASTENV11physical
20620961
TBF1_YEASTTBF1physical
22130795
VID22_YEASTVID22genetic
23222485
MRE11_YEASTMRE11genetic
23222485
MMS4_YEASTMMS4genetic
23222485
SGS1_YEASTSGS1genetic
23222485
ESA1_YEASTESA1genetic
23222485
SWR1_YEASTSWR1genetic
23222485
RSC2_YEASTRSC2genetic
23222485
ARP8_YEASTARP8genetic
23222485
RAD52_YEASTRAD52genetic
23222485
RAD51_YEASTRAD51genetic
23222485
RPD3_YEASTRPD3genetic
23222485
BIT61_YEASTBIT61genetic
27708008
MRS3_YEASTMRS3genetic
27708008
RS14B_YEASTRPS14Bgenetic
27708008
ECM25_YEASTECM25genetic
27708008
DPH5_YEASTDPH5genetic
27708008
YBM6_YEASTYBR016Wgenetic
27708008
SNF11_YEASTSNF11genetic
27708008
DENR_YEASTTMA22genetic
27708008
CSN12_YEASTYJR084Wgenetic
27708008
CSF1_YEASTCSF1genetic
27708008
TLG2_YEASTTLG2genetic
27708008
RAS1_YEASTRAS1genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TBF1_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-498 AND SER-501, ANDMASS SPECTROMETRY.

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