| UniProt ID | TLG2_YEAST | |
|---|---|---|
| UniProt AC | Q08144 | |
| Protein Name | t-SNARE affecting a late Golgi compartment protein 2 | |
| Gene Name | TLG2 | |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). | |
| Sequence Length | 397 | |
| Subcellular Localization |
Golgi apparatus, trans-Golgi network membrane Single-pass type IV membrane protein. Endosome membrane Single-pass type IV membrane protein. |
|
| Protein Description | t-SNARE that functions in transport from the endosome to the late Golgi and on the endocytic pathway.. | |
| Protein Sequence | MFRDRTNLFLSYRRTFPHNITFSSGKAPLGDDQDIEMGTYPMMNMSHDISARLTDERKNKHENHSDALPPIFIDIAQDVDDYLLEVRRLSEQLAKVYRKNSLPGFEDKSHDEALIEDLSFKVIQMLQKCYAVMKRLKTIYNSQFVDGKQLSREELIILDNLQKIYAEKIQTESNKFRVLQNNYLKFLNKDDLKPIRNKASAENTLLLDDEEEEAAREKREGLDIEDYSKRTLQRQQQLHDTSAEAYLRERDEEITQLARGVLEVSTIFREMQDLVVDQGTIVDRIDYNLENTVVELKSADKELNKATHYQKRTQKCKVILLLTLCVIALFFFVMLKPHGGGSGGRNNGSNKYNNDDNKTVNNSHDDGSNTHINDEESNLPSIVEVTESENDALDDLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 95 | Acetylation | RLSEQLAKVYRKNSL HHHHHHHHHHHHCCC | 48.68 | 24489116 | |
| 101 | Phosphorylation | AKVYRKNSLPGFEDK HHHHHHCCCCCCCCC | 38.69 | 21440633 | |
| 109 | Phosphorylation | LPGFEDKSHDEALIE CCCCCCCCCCHHHHH | 48.79 | 21440633 | |
| 119 | Phosphorylation | EALIEDLSFKVIQML HHHHHHHHHHHHHHH | 35.03 | 27017623 | |
| 142 | Phosphorylation | RLKTIYNSQFVDGKQ HHHHHHHHCCCCCCC | 14.18 | 27017623 | |
| 148 | Ubiquitination | NSQFVDGKQLSREEL HHCCCCCCCCCHHHE | 43.53 | 24961812 | |
| 189 | Acetylation | NYLKFLNKDDLKPIR HHHHHCCHHHCHHHC | 55.56 | 24489116 | |
| 193 | Acetylation | FLNKDDLKPIRNKAS HCCHHHCHHHCCCCC | 45.45 | 24489116 | |
| 193 | Ubiquitination | FLNKDDLKPIRNKAS HCCHHHCHHHCCCCC | 45.45 | 22817900 | |
| 198 | Ubiquitination | DLKPIRNKASAENTL HCHHHCCCCCCCCCE | 33.59 | 23749301 | |
| 200 | Phosphorylation | KPIRNKASAENTLLL HHHCCCCCCCCCEEC | 37.41 | 24961812 | |
| 204 | Phosphorylation | NKASAENTLLLDDEE CCCCCCCCEECCHHH | 15.41 | 24961812 | |
| 229 | Ubiquitination | LDIEDYSKRTLQRQQ CCHHHHHHHHHHHHH | 43.08 | 23749301 | |
| 297 | Ubiquitination | ENTVVELKSADKELN CCEEEEEHHHCHHHH | 30.05 | 24961812 | |
| 301 | Ubiquitination | VELKSADKELNKATH EEEHHHCHHHHHHHH | 64.91 | 23749301 | |
| 349 | Phosphorylation | SGGRNNGSNKYNNDD CCCCCCCCCCCCCCC | 32.07 | 28889911 | |
| 352 | Phosphorylation | RNNGSNKYNNDDNKT CCCCCCCCCCCCCCC | 24.37 | 28889911 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TLG2_YEAST !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TLG2_YEAST !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TLG2_YEAST !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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