SNC1_YEAST - dbPTM
SNC1_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SNC1_YEAST
UniProt AC P31109
Protein Name Synaptobrevin homolog 1
Gene Name SNC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 117
Subcellular Localization Endomembrane system
Single-pass type IV membrane protein. Post-Golgi vesicle membrane.
Protein Description SNC1 and SNC2 are vesicle-targeting proteins essential for normal secretory traffic between the Golgi and the plasma membrane. They may also be involved in vesicle fusion..
Protein Sequence MSSSTPFDPYALSEHDEERPQNVQSKSRTAELQAEIDDTVGIMRDNINKVAERGERLTSIEDKADNLAVSAQGFKRGANRVRKAMWYKDLKMKMCLALVIIILLVVIIVPIAVHFSR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSSSTPFDP
------CCCCCCCCC		32.7522369663
3Phosphorylation-----MSSSTPFDPY
-----CCCCCCCCCC		36.6122369663
4Phosphorylation----MSSSTPFDPYA
----CCCCCCCCCCC		32.5622369663
5Phosphorylation---MSSSTPFDPYAL
---CCCCCCCCCCCC		29.8922369663
10PhosphorylationSSTPFDPYALSEHDE
CCCCCCCCCCCCCCC		23.2422369663
13PhosphorylationPFDPYALSEHDEERP
CCCCCCCCCCCCCCC		25.3922369663
25PhosphorylationERPQNVQSKSRTAEL
CCCCCHHCCHHHHHH		28.4622369663
26UbiquitinationRPQNVQSKSRTAELQ
CCCCHHCCHHHHHHH		27.1924961812
27PhosphorylationPQNVQSKSRTAELQA
CCCHHCCHHHHHHHH		39.8619779198
29PhosphorylationNVQSKSRTAELQAEI
CHHCCHHHHHHHHHH		31.4121440633
49UbiquitinationIMRDNINKVAERGER
HHHHHHHHHHHHHHC		38.7423749301
58PhosphorylationAERGERLTSIEDKAD
HHHHHCCCCHHHHHH		33.6020377248
59PhosphorylationERGERLTSIEDKADN
HHHHCCCCHHHHHHH		28.6822369663
63UbiquitinationRLTSIEDKADNLAVS
CCCCHHHHHHHHHHH		44.8623749301
63AcetylationRLTSIEDKADNLAVS
CCCCHHHHHHHHHHH		44.8624489116
70PhosphorylationKADNLAVSAQGFKRG
HHHHHHHHHHHHHHH		14.8522369663
75UbiquitinationAVSAQGFKRGANRVR
HHHHHHHHHHHHHHH		57.6623749301
75AcetylationAVSAQGFKRGANRVR
HHHHHHHHHHHHHHH		57.6624489116
95S-palmitoylationKDLKMKMCLALVIII
HHHHHHHHHHHHHHH		1.35-
95S-palmitoylationKDLKMKMCLALVIII
HHHHHHHHHHHHHHH		1.3515973437
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SNC1_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SNC1_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SNC1_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SEC9_YEASTSEC9physical
10402465
PEP12_YEASTPEP12physical
12453154
SSO1_YEASTSSO1physical
11038189
SSO1_YEASTSSO1physical
10402465
DDI1_YEASTDDI1physical
10330187
SEC9_YEASTSEC9physical
8089101
SNX4_YEASTSNX4physical
12554655
VPS54_YEASTVPS54physical
11689439
SEC17_YEASTSEC17physical
9195974
SEC9_YEASTSEC9physical
9195974
SSO1_YEASTSSO1physical
9195974
SGPL_YEASTDPL1genetic
11102507
PP11_YEASTSIT4genetic
12006655
SNC2_YEASTSNC2genetic
12006655
SNC2_YEASTSNC2genetic
8374953
CLH_YEASTCHC1genetic
11847108
PEP12_YEASTPEP12genetic
11847108
VAM3_YEASTVAM3genetic
11847108
VPS1_YEASTVPS1genetic
11847108
VPS34_YEASTVPS34genetic
11847108
SEC9_YEASTSEC9genetic
8089101
SNC2_YEASTSNC2genetic
9195971
LCF4_YEASTFAA4genetic
16233202
ARF1_YEASTARF1physical
17522384
SEC17_YEASTSEC17physical
17522384
SEC18_YEASTSEC18physical
17522384
ELO2_YEASTELO2genetic
9832547
ELO3_YEASTELO3genetic
9832547
SNX4_YEASTSNX4physical
19591838
SSO1_YEASTSSO1physical
19591838
ECM8_YEASTECM8genetic
20093466
CYK3_YEASTCYK3genetic
20093466
SWF1_YEASTSWF1genetic
20093466
YIT6_YEASTYIR016Wgenetic
20093466
SNC2_YEASTSNC2genetic
20093466
ELO3_YEASTELO3genetic
12006655
SEC17_YEASTSEC17genetic
9195971
SEC9_YEASTSEC9genetic
9195971
SSO2_YEASTSSO2genetic
9195971
SNC2_YEASTSNC2genetic
20526336
SNC2_YEASTSNC2genetic
21686101
SEC9_YEASTSEC9physical
7954793
HSP71_YEASTSSA1physical
22940862
SNX4_YEASTSNX4physical
22875988
SSO1_YEASTSSO1physical
21477180
SSO2_YEASTSSO2physical
21477180
SNC2_YEASTSNC2physical
21477180
SSO1_YEASTSSO1genetic
24639206
SEC9_YEASTSEC9genetic
24639206
SNC2_YEASTSNC2genetic
23897890
ECM8_YEASTECM8genetic
27708008
SWF1_YEASTSWF1genetic
27708008
UME6_YEASTUME6genetic
27708008
SNC2_YEASTSNC2genetic
27708008
MDL2_YEASTMDL2genetic
27708008
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SNC1_YEAST

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Related Literatures of Post-Translational Modification
Palmitoylation
ReferencePubMed
"Swf1-dependent palmitoylation of the SNARE Tlg1 prevents itsubiquitination and degradation.";
Valdez-Taubas J., Pelham H.R.B.;
EMBO J. 24:2524-2532(2005).
Cited for: PALMITOYLATION AT CYS-95.
Ubiquitylation
ReferencePubMed
"A proteomics approach to understanding protein ubiquitination.";
Peng J., Schwartz D., Elias J.E., Thoreen C.C., Cheng D.,Marsischky G., Roelofs J., Finley D., Gygi S.P.;
Nat. Biotechnol. 21:921-926(2003).
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-63, AND MASSSPECTROMETRY.

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