CLH_YEAST - dbPTM
CLH_YEAST - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CLH_YEAST
UniProt AC P22137
Protein Name Clathrin heavy chain
Gene Name CHC1
Organism Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length 1653
Subcellular Localization Cytoplasmic vesicle membrane
Peripheral membrane protein
Cytoplasmic side. Membrane, coated pit
Peripheral membrane protein
Cytoplasmic side. Cytoplasmic face of coated pits and vesicles.
Protein Description Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. In yeast, it is involved in the retention of proteins in an intracellular membrane compartment, presumably the trans-Golgi..
Protein Sequence MSDLPIEFTELVDLMSLGISPQFLDFRSTTFESDHFVTVRETKDGTNSVAIVDLAKGNEVTRKNMGGDSAIMHPSQMVISVRANGTIVQIFNLETKSKLKSFTLDEPVIFWRWLSETTLGFVTARSILTSNVFDGNVNAKPQLLTLRHANLNNTQIINFVANKNLDWFAVVGILQENGRIAGRIQLFSKQRNISQAIDGHVAIFTNILLEGNGSTPVQVFVTGNRNATTGAGELRIIEIDHDASLPSQYQKETTDIFFPPDATNDFPIAVQVSEKYGIIYLLTKYGFIHLYELETGTNLFVNRITAESVFTAAPYNHENGIACINKKGQVLAVEISTSQIVPYILNKLSNVALALIVATRGGLPGADDLFQKQFESLLLQNDYQNAAKVAASSTSLRNQNTINRLKNIQAPPGAISPILLYFSTLLDKGKLNKEETIELARPVLQQDRKQLFEKWLKEDKLECSEELGDIVKPFDTTLALACYLRAGAHAKVISCLAELQQFEKIIPYCQKVGYQPNFLVLISSLIRSSPDRASEFAVSLLQNPETASQIDIEKIADLFFSQNHIQQGTSLLLDALKGDTPDQGHLQTRVLEVNLLHAPQVADAILGNNIFSHYDKPTIASLSEKAGLYQRALENYTDIKDIKRCVVHTNALPIDWLVGYFGKLNVEQSLACLKALMDNNIQANIQTVVQVATKFSDLIGPSTLIKLFEDYNATEGLYYYLASLVNLTEDKDVVYKYIEAAAKMKQYREIERIVKDNNVYDPERVKNFLKDANLEDQLPLVIVCDRFDFVHEMILYLYKSQNLKFIETYVQQVNPSKTAQVVGALLDMDCDEAFIQSLLQSVLGQVPINELTTEVEKRNRLKILLPFLEQSLSQGIQDQAVYNALAKIYIDSNNSPEKFLKENDQYDTLDVGHYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLERSDLDLWNKVLNQENIHRRQLIDSVISVGIPELTDPEPVSLTVQAFMTNGLKLELIELLEKIILEPSPFNENVALQGLLLLSAIKYEPTKVSSYIEKLDNYDADEIAPLCIEHDLKEEAFEIYDKHEMYGKALKVLIEDIMSLDRAASYADKINTPELWSQIGTAQLDGLRIPDAIESYIKAEDPSNYENVIDIAEQAGKYEELIPFLLMARKTLKEPKIDGALILAYAELNKIHEIENLLAGSNVANLDHVGDKLFENKEYKAARLCYSAVSNYSKLASTLVYLGDYQAAVDTARKASNIKVWKLVNDACIEKKEFKLAQICGLNLIVHAEELDELVERYESNGYFEELISLFEAGLGLERAHMGMFTELAILYSKYEPDKTFEHLKLFWSRINIPKVIRAVEQAHLWSELVFLYAHYDEWDNAALTLIEKSTKDLDHAYFKEVVVKVSNLEIYYKAINFYVKFHPSLLVDLLTSLTPRLDIPRTVKIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEEDYKALQDAVDSYDKFDQLGLASRLESHKLIFFKKIGALLYRRNKKWAKSLSILKEEKLWKDAIETAAISQDPKVVEALLTYFVETGNREGFVALLYAAYNLVRIEFVLEISWMNSLEDYIKPFEISIKKEQNDSIKKITEELAKKSGSNEEHKDGQPLMLMNSAMNVQPTGF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Phosphorylation------MSDLPIEFT
------CCCCCCCHH		60.1930377154
9PhosphorylationSDLPIEFTELVDLMS
CCCCCCHHHHHHHHH		18.6730377154
16PhosphorylationTELVDLMSLGISPQF
HHHHHHHHCCCCHHH		30.6430377154
43UbiquitinationFVTVRETKDGTNSVA
EEEEEECCCCCCEEE		49.7823749301
56UbiquitinationVAIVDLAKGNEVTRK
EEEEEECCCCCCCCC		70.3523749301
69PhosphorylationRKNMGGDSAIMHPSQ
CCCCCCCCCEECHHH		23.9927017623
75PhosphorylationDSAIMHPSQMVISVR
CCCEECHHHEEEEEE		19.0727017623
80PhosphorylationHPSQMVISVRANGTI
CHHHEEEEEEECCEE		8.3027017623
100UbiquitinationLETKSKLKSFTLDEP
CCCCCCCCCCCCCCC		47.4617644757
140UbiquitinationFDGNVNAKPQLLTLR
CCCCCCCCCEEEEEE		28.2623749301
163UbiquitinationIINFVANKNLDWFAV
EEEEECCCCCCEEEE		49.5017644757
284UbiquitinationGIIYLLTKYGFIHLY
CCEEEEECCCEEEEE		43.2617644757
372UbiquitinationGADDLFQKQFESLLL
CHHHHHHHHHHHHHC		50.0123749301
394PhosphorylationAKVAASSTSLRNQNT
HHHHHCCHHHCCCHH		29.3230377154
406UbiquitinationQNTINRLKNIQAPPG
CHHHHHHHCCCCCCC		49.0917644757
428UbiquitinationYFSTLLDKGKLNKEE
HHHHHHHCCCCCHHH		58.8917644757
433AcetylationLDKGKLNKEETIELA
HHCCCCCHHHHHHHH		68.3224489116
454AcetylationDRKQLFEKWLKEDKL
HHHHHHHHHHHHCCC		50.9524489116
491UbiquitinationLRAGAHAKVISCLAE
HHHCHHHHHHHHHHH		30.1817644757
504UbiquitinationAELQQFEKIIPYCQK
HHHHHHHHHHHHHHH		47.4217644757
511UbiquitinationKIIPYCQKVGYQPNF
HHHHHHHHHCCCCCH		33.7817644757
616UbiquitinationNIFSHYDKPTIASLS
CCCCCCCCCCHHHHH		36.5717644757
625UbiquitinationTIASLSEKAGLYQRA
CHHHHHHHHCHHHHH		44.3617644757
640AcetylationLENYTDIKDIKRCVV
HHCCCCHHHHHHHHE		57.1024489116
640SuccinylationLENYTDIKDIKRCVV
HHCCCCHHHHHHHHE		57.1023954790
643AcetylationYTDIKDIKRCVVHTN
CCCHHHHHHHHEECC		50.2924489116
663UbiquitinationWLVGYFGKLNVEQSL
HHHHHHCCCCHHHHH		27.3017644757
674UbiquitinationEQSLACLKALMDNNI
HHHHHHHHHHHCCCH		39.0817644757
694UbiquitinationTVVQVATKFSDLIGP
HHHHHHHHHHHHHCH		32.8817644757
706UbiquitinationIGPSTLIKLFEDYNA
HCHHHHHHHHCCCCC		50.6817644757
731UbiquitinationLVNLTEDKDVVYKYI
HCCCCCCHHHHHHHH		46.3017644757
736UbiquitinationEDKDVVYKYIEAAAK
CCHHHHHHHHHHHHH		28.3017644757
755UbiquitinationREIERIVKDNNVYDP
HHHHHHHCCCCCCCH		52.9817644757
766UbiquitinationVYDPERVKNFLKDAN
CCCHHHHHHHHHHCC		48.4817644757
804AcetylationLYKSQNLKFIETYVQ
HHHCCCCHHHHHHHH		52.4224489116
804UbiquitinationLYKSQNLKFIETYVQ
HHHCCCCHHHHHHHH		52.4217644757
817UbiquitinationVQQVNPSKTAQVVGA
HHHCCHHHHHHHHHH		49.4917644757
862UbiquitinationVEKRNRLKILLPFLE
HHHHHHHHHHHHHHH		28.2417644757
887UbiquitinationAVYNALAKIYIDSNN
HHHHHHHHHHHCCCC		36.5717644757
889PhosphorylationYNALAKIYIDSNNSP
HHHHHHHHHCCCCCH		9.6628889911
892PhosphorylationLAKIYIDSNNSPEKF
HHHHHHCCCCCHHHH		28.4928889911
895PhosphorylationIYIDSNNSPEKFLKE
HHHCCCCCHHHHHHH		38.3925704821
898AcetylationDSNNSPEKFLKENDQ
CCCCCHHHHHHHCCC		60.4224489116
917UbiquitinationDVGHYCEKRDPYLAY
CHHHHHCCCCCEEEE		59.5517644757
917AcetylationDVGHYCEKRDPYLAY
CHHHHHCCCCCEEEE		59.5524489116
924PhosphorylationKRDPYLAYIAYEKGQ
CCCCEEEEEEECCCC		5.4028889911
927PhosphorylationPYLAYIAYEKGQNDD
CEEEEEEECCCCCCC		14.4928889911
929UbiquitinationLAYIAYEKGQNDDDL
EEEEEECCCCCCCCC		53.7917644757
947UbiquitinationTNENSMYKYQARYLL
CCCCHHHHHHHHHHH		23.4223749301
947AcetylationTNENSMYKYQARYLL
CCCCHHHHHHHHHHH		23.4222865919
964UbiquitinationSDLDLWNKVLNQENI
CCHHHHHHHHCCCCH		36.2017644757
964AcetylationSDLDLWNKVLNQENI
CCHHHHHHHHCCCCH		36.2024489116
1107UbiquitinationRAASYADKINTPELW
HHHHHHHHCCCHHHH		29.6823749301
1210AcetylationNLDHVGDKLFENKEY
CCCCCCHHHHCCHHH		49.5024489116
1215SuccinylationGDKLFENKEYKAARL
CHHHHCCHHHHHHHH		56.0523954790
12152-HydroxyisobutyrylationGDKLFENKEYKAARL
CHHHHCCHHHHHHHH		56.05-
1231PhosphorylationYSAVSNYSKLASTLV
HHHHHCHHHHHHHHH		25.9919779198
12572-HydroxyisobutyrylationARKASNIKVWKLVND
HHHHHCCCHHHHHCH		46.42-
1337AcetylationYSKYEPDKTFEHLKL
HHCCCCCCCHHHHHH		66.8724489116
1343AcetylationDKTFEHLKLFWSRIN
CCCHHHHHHHHHHCC		43.4724489116
1353AcetylationWSRINIPKVIRAVEQ
HHHCCHHHHHHHHHH		46.6424489116
1398AcetylationDLDHAYFKEVVVKVS
CCCHHHHHHHEEEEE		36.6024489116
1447UbiquitinationRTVKIFSKSDNLPLI
CEEEEEECCCCCCCC		51.5924961812
1447AcetylationRTVKIFSKSDNLPLI
CEEEEEECCCCCCCC		51.5924489116
1447SuccinylationRTVKIFSKSDNLPLI
CEEEEEECCCCCCCC		51.5923954790
1455AcetylationSDNLPLIKPFLINVL
CCCCCCCHHHHEEEC		37.0824489116
1455UbiquitinationSDNLPLIKPFLINVL
CCCCCCCHHHHEEEC		37.0824961812
1464UbiquitinationFLINVLPKNNSVVNQ
HHEEECCCCCHHHHH		65.6817644757
1467PhosphorylationNVLPKNNSVVNQAYH
EECCCCCHHHHHHHH		36.5121440633
1484UbiquitinationMIEEEDYKALQDAVD
HCCHHHHHHHHHHHH		55.7517644757
1495AcetylationDAVDSYDKFDQLGLA
HHHHHCHHHHHHCHH		42.4824489116
1495UbiquitinationDAVDSYDKFDQLGLA
HHHHHCHHHHHHCHH		42.4817644757
1509AcetylationASRLESHKLIFFKKI
HHHHHHCCEEHHHHH		53.1924489116
15142-HydroxyisobutyrylationSHKLIFFKKIGALLY
HCCEEHHHHHHHHHH		32.50-
1515UbiquitinationHKLIFFKKIGALLYR
CCEEHHHHHHHHHHH		41.0123749301
1529AcetylationRRNKKWAKSLSILKE
HHCHHHHHHHHHHHH		51.3024489116
15352-HydroxyisobutyrylationAKSLSILKEEKLWKD
HHHHHHHHHHHHHHH		63.26-
1535AcetylationAKSLSILKEEKLWKD
HHHHHHHHHHHHHHH		63.2624489116
1535UbiquitinationAKSLSILKEEKLWKD
HHHHHHHHHHHHHHH		63.2623749301
1538AcetylationLSILKEEKLWKDAIE
HHHHHHHHHHHHHHH		61.8224489116
1602UbiquitinationNSLEDYIKPFEISIK
HCHHHHHHHHEEEEC		37.1115699485
1651PhosphorylationSAMNVQPTGF-----
CCCCCCCCCC-----		33.8425521595
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CLH_YEAST !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CLH_YEAST !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CLH_YEAST !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CLC1_YEASTCLC1physical
11805826
LYS12_YEASTLYS12physical
11805826
CLC1_YEASTCLC1physical
12181333
SLA2_YEASTSLA2physical
12181333
SLA2_YEASTSLA2physical
15992543
STE2_YEASTSTE2physical
15992543
ABP1_YEASTABP1physical
15992543
ENT1_YEASTENT1physical
15992543
ENT2_YEASTENT2physical
15992543
AP18A_YEASTYAP1801physical
15992543
AP18B_YEASTYAP1802physical
15992543
SCD5_YEASTSCD5genetic
12181333
SCD5_YEASTSCD5genetic
8688556
AP1B1_YEASTAPL2genetic
11489214
AP1B1_YEASTAPL2genetic
10564262
AP1B1_YEASTAPL2genetic
7615679
AP1M1_YEASTAPM1genetic
7749194
SLA2_YEASTSLA2genetic
12181333
VPS1_YEASTVPS1genetic
10628971
INP53_YEASTINP53genetic
10628971
RIC1_YEASTRIC1genetic
10628971
VPS54_YEASTVPS54genetic
10628971
VPS5_YEASTVPS5genetic
10628971
VPS21_YEASTVPS21genetic
10628971
PEP12_YEASTPEP12genetic
10628971
VPS17_YEASTVPS17genetic
10628971
PP2C1_YEASTPTC1genetic
10628971
UBI4P_YEASTUBI4genetic
8380227
VPS10_YEASTPEP1genetic
12475953
PEP12_YEASTPEP12genetic
12475953
VPS35_YEASTVPS35genetic
12475953
SEC6_YEASTSEC6genetic
12475953
END3_YEASTEND3genetic
12475953
BMH1_YEASTBMH1genetic
8524799
BMH2_YEASTBMH2genetic
8524799
AP1S1_YEASTAPS1genetic
8157009
AP2S_YEASTAPS2genetic
8157009
AP1G1_YEASTAPL4genetic
10564262
AP1M1_YEASTAPM1genetic
10564262
AP1S1_YEASTAPS1genetic
10564262
CLC1_YEASTCLC1physical
16554755
CLC1_YEASTCLC1physical
16429126
HSP7F_YEASTSSE1physical
16429126
LYS12_YEASTLYS12physical
16429126
CLC1_YEASTCLC1physical
16643280
CLC1_YEASTCLC1physical
16870700
INO1_YEASTINO1physical
18467557
STI1_YEASTSTI1physical
18467557
AGE2_YEASTAGE2physical
18467557
SLA2_YEASTSLA2physical
18467557
AP1G1_YEASTAPL4physical
18467557
FHP_YEASTYHB1physical
18467557
SIS1_YEASTSIS1physical
18467557
ARPC3_YEASTARC18physical
18467557
HSP71_YEASTSSA1physical
19536198
ENT2_YEASTENT2genetic
19458198
LAA1_YEASTLAA1genetic
16687571
CLC1_YEASTCLC1genetic
9133677
SRO7_YEASTSRO7genetic
20526336
EDE1_YEASTEDE1genetic
20526336
FAB1_YEASTFAB1genetic
20526336
ERG2_YEASTERG2genetic
20526336
CLC1_YEASTCLC1genetic
16870700
ROM1_YEASTROM1genetic
22065638
IRC6_YEASTIRC6genetic
22993212
SEC4_YEASTSEC4genetic
23897890
PMP1_YEASTPMP1physical
26404137
CSK22_YEASTCKA2physical
25268174
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CLH_YEAST

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"A multidimensional chromatography technology for in-depthphosphoproteome analysis.";
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
Mol. Cell. Proteomics 7:1389-1396(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-892, AND MASSSPECTROMETRY.

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