dbPTM

IRC6_YEAST - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IRC6_YEAST
UniProt AC	P43615
Protein Name	Increased recombination centers protein 6
Gene Name	IRC6
Organism	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Sequence Length	237
Subcellular Localization
Protein Description	Involved in gross chromosomal rearrangements (GCRs) and telomere healing..
Protein Sequence	MVLQYPQNKILVLSDHPHNFLKTQFLQDLFHCSSTGISIVKDQTWENRYYKVHFDLYIDSCKEIPVWVEEFITPECEPLRNVMAGIILITDIRQTKPQELLHQFMIAAHRNTFVVLANVNEEVEQDEIDELNEIWSNAFTNVIEFVNWKRSKPTVNHNDYGEKLGLDRIQEIIDTHDWLNCEVQPATKIREEIPNEMPLEQIIRNLQSARLKYKSIENSSEADAFANEMADELSRYL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
215	Phosphorylation	SARLKYKSIENSSEA HCCHHHHHCCCCHHH	31.85	30377154
219	Phosphorylation	KYKSIENSSEADAFA HHHHCCCCHHHHHHH	19.43	30377154
220	Phosphorylation	YKSIENSSEADAFAN HHHCCCCHHHHHHHH	48.67	30377154

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IRC6_YEAST !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IRC6_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IRC6_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SLD5_YEAST	SLD5	physical	10688190
YPT31_YEAST	YPT31	physical	22993212
AP1B1_YEAST	APL2	physical	22993212
AP2B_YEAST	APL1	physical	22993212
SEC4_YEAST	SEC4	physical	22993212
SNU56_YEAST	SNU56	genetic	27708008
SEN1_YEAST	SEN1	genetic	27708008
CDC24_YEAST	CDC24	genetic	27708008
CND2_YEAST	BRN1	genetic	27708008
KPC1_YEAST	PKC1	genetic	27708008
ORC2_YEAST	ORC2	genetic	27708008
CALM_YEAST	CMD1	genetic	27708008
DPOD_YEAST	POL3	genetic	27708008
KIN28_YEAST	KIN28	genetic	27708008
COPA_YEAST	COP1	genetic	27708008
RPC10_YEAST	RPC11	genetic	27708008
CDC1_YEAST	CDC1	genetic	27708008
TCPZ_YEAST	CCT6	genetic	27708008
TCPA_YEAST	TCP1	genetic	27708008
TRS23_YEAST	TRS23	genetic	27708008
TFB1_YEAST	TFB1	genetic	27708008
RSP5_YEAST	RSP5	genetic	27708008
STT3_YEAST	STT3	genetic	27708008
COPB2_YEAST	SEC27	genetic	27708008
SPT16_YEAST	SPT16	genetic	27708008
SEC15_YEAST	SEC15	genetic	27708008
BRR6_YEAST	BRR6	genetic	27708008
PTI1_YEAST	PTI1	genetic	27708008
RPC9_YEAST	RPC17	genetic	27708008
RRN7_YEAST	RRN7	genetic	27708008
GRP78_YEAST	KAR2	genetic	27708008
ARP4_YEAST	ARP4	genetic	27708008
KRE9_YEAST	KRE9	genetic	27708008
DPOD2_YEAST	POL31	genetic	27708008
UGPA1_YEAST	UGP1	genetic	27708008
YKT6_YEAST	YKT6	genetic	27708008
BET3_YEAST	BET3	genetic	27708008
SSL1_YEAST	SSL1	genetic	27708008
NSE1_YEAST	NSE1	genetic	27708008
BOS1_YEAST	BOS1	genetic	27708008
SEC13_YEAST	SEC13	genetic	27708008
SEC22_YEAST	SEC22	genetic	27708008
TEM1_YEAST	TEM1	genetic	27708008
BET5_YEAST	BET5	genetic	27708008
ROT1_YEAST	ROT1	genetic	27708008
GPI12_YEAST	GPI12	genetic	27708008
LST8_YEAST	LST8	genetic	27708008
CAP_YEAST	SRV2	genetic	27708008
RPC6_YEAST	RPC34	genetic	27708008
ARPC2_YEAST	ARC35	genetic	27708008
TPT1_YEAST	TPT1	genetic	27708008
HRP1_YEAST	HRP1	genetic	27708008
KRE5_YEAST	KRE5	genetic	27708008
MOT1_YEAST	MOT1	genetic	27708008
ARP7_YEAST	ARP7	genetic	27708008

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IRC6_YEAST

Related Literatures of Post-Translational Modification