ARP7_YEAST - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARP7_YEAST
• UniProt AC: Q12406
• Protein Name: Actin-related protein 7
• Gene Name: ARP7
• Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
• Sequence Length: 477
• Subcellular Localization: Nucleus . Localizes to centromeric and flanking chromatin. Association with these loci is dependent on STH1.
• Protein Description: Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is involved in transcriptional regulation. Heterodimer of ARP7 and ARP9 functions with HMG box proteins to facilitate proper chromatin architecture. Heterodimer formation is necessary for assembly into RSC complex. Part of the SWI/SNF complex, an ATP-dependent chromatin remodeling complex, is required for the positive and negative regulation of gene expression of a large number of genes. It changes chromatin structure by altering DNA-histone contacts within a nucleosome, leading eventually to a change in nucleosome position, thus facilitating or repressing binding of gene-specific transcription factors..
• Protein Sequence: MTLNRKCVVIHNGSHRTVAGFSNVELPQCIIPSSYIKRTDEGGEAEFIFGTYNMIDAAAEKRNGDEVYTLVDSQGLPYNWDALEMQWRYLYDTQLKVSPEELPLVITMPATNGKPDMAILERYYELAFDKLNVPVFQIVIEPLAIALSMGKSSAFVIDIGASGCNVTPIIDGIVVKNAVVRSKFGGDFLDFQVHERLAPLIKEENDMENMADEQKRSTDVWYEASTWIQQFKSTMLQVSEKDLFELERYYKEQADIYAKQQEQLKQMDQQLQYTALTGSPNNPLVQKKNFLFKPLNKTLTLDLKECYQFAEYLFKPQLISDKFSPEDGLGPLMAKSVKKAGASINSMKANTSTNPNGLGTSHINTNVGDNNSTASSSNISPEQVYSLLLTNVIITGSTSLIEGMEQRIIKELSIRFPQYKLTTFANQVMMDRKIQGWLGALTMANLPSWSLGKWYSKEDYETLKRDRKQSQATNATN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Ubiquitination	IIPSSYIKRTDEGGE ECCHHHEEECCCCCC	40.80	23749301
183	Acetylation	KNAVVRSKFGGDFLD ECCEEECCCCCCCCC	37.15	24489116
273	Phosphorylation	QMDQQLQYTALTGSP HHHHHHHHHHHHCCC	11.54	22369663
274	Phosphorylation	MDQQLQYTALTGSPN HHHHHHHHHHHCCCC	11.39	22369663
277	Phosphorylation	QLQYTALTGSPNNPL HHHHHHHHCCCCCHH	32.90	22369663
279	Phosphorylation	QYTALTGSPNNPLVQ HHHHHHCCCCCHHHC	21.15	22369663
293	Acetylation	QKKNFLFKPLNKTLT CCCCCCCCCCCCEEE	51.23	24489116
336	Phosphorylation	LGPLMAKSVKKAGAS CHHHHHHHHHHHCCC	29.63	28889911
343	Phosphorylation	SVKKAGASINSMKAN HHHHHCCCHHHCCCC	22.76	28889911
470	Phosphorylation	LKRDRKQSQATNATN HHHHHHHHHHHCCCC	25.47	27214570

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARP7_YEAST !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARP7_YEAST !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARP7_YEAST !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STH1_YEAST	STH1	physical	12805231
SWI3_YEAST	SWI3	physical	12805231
ARP9_YEAST	ARP9	physical	12805231
ARP9_YEAST	ARP9	genetic	12805231
NHP6A_YEAST	NHP6A	genetic	12805231
PSK1_YEAST	PSK1	physical	16554755
MPG1_YEAST	PSA1	physical	16554755
URC2_YEAST	URC2	physical	16554755
BEM2_YEAST	BEM2	physical	16554755
YIR7_YEAST	YIL177C	physical	16554755
GLG2_YEAST	GLG2	physical	16554755
SWI3_YEAST	SWI3	physical	16554755
MLH2_YEAST	MLH2	physical	16554755
ARP9_YEAST	ARP9	physical	16554755
ATG16_YEAST	ATG16	physical	16554755
MKT1_YEAST	MKT1	physical	16554755
SIZ2_YEAST	NFI1	physical	16554755
SWI1_YEAST	SWI1	physical	16554755
SYG2_YEAST	GRS2	physical	16554755
SNF2_YEAST	SNF2	physical	16429126
VPS1_YEAST	VPS1	physical	16429126
SWP82_YEAST	SWP82	physical	16429126
H4_YEAST	HHF1	physical	16429126
H2A1_YEAST	HTA1	physical	16429126
ISW1_YEAST	ISW1	physical	16429126
RSC7_YEAST	NPL6	physical	16429126
RSC1_YEAST	RSC1	physical	16429126
RSC2_YEAST	RSC2	physical	16429126
RSC3_YEAST	RSC3	physical	16429126
RSC4_YEAST	RSC4	physical	16429126
RSC58_YEAST	RSC58	physical	16429126
RSC6_YEAST	RSC6	physical	16429126
RSC8_YEAST	RSC8	physical	16429126
SFH1_YEAST	SFH1	physical	16429126
STH1_YEAST	STH1	physical	16429126
STH1_YEAST	STH1	genetic	18408732
RT102_YEAST	RTT102	genetic	23401505
ARP9_YEAST	ARP9	physical	24189066

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.